Src (phospho Y529) | p-Src (phospho Y529) | Src(Phospho-Tyr529) | ASV | Avian sarcoma virus | c SRC | CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA | cSrc | EC 2.7.10.2 | Neuronal CSRC tyr
规格或纯度
已验证, ExactAb™, 1.0 mg/mL
生化机理
Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.
Src (phospho Y529) Antibody (Ab129131) - Western Blot All lanes: Src (phospho Y529) Antibody (Ab129131) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 60 kDa Observed band size: 58 kDa Exposure time: 3.0 s
Src (phospho Y529) Antibody (Ab129131) - Western Blot All lanes: Src (phospho Y529) Antibody (Ab129131) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 60 kDa Observed band size: 58 kDa Exposure time: 5.0 s
Src (phospho Y529) Antibody (Ab129131) - IHC Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Src (phospho Y529) Antibody (Ab129131). The picture on the right is blocked with the phospho peptide.
Src (phospho Y529) Antibody (Ab129131) - ELISA Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Src (phospho Y529) Antibody (Ab129131).
ZJ25F0622815
危险品化学品经营许可证（带存储）