Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
宿主种属
兔(Rabbit)
特异性
Src
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Src (AA 250-536)
阳性对照
WB: HeLa, Jurkat, Hep G2, MCF7, HEK293, A431, NIH/3T3 and C6 cell lysates.
Recombinant Src Antibody (Ab129134) - Western Blot All lanes: Recombinant Src Antibody (Ab129134) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 60 kDa Observed band size: 59 kDa Exposure time: 100.0 s