ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Isatuximab 是一种单克隆抗体，靶向跨膜受体和胞外酶 CD38，一种在血液系统恶性细胞，包括多发性骨髓瘤中高度表达的蛋白。Isatuximab 通过多种生物学机制具有抗肿瘤活性，包括抗体依赖性细胞介导的细胞毒性、补体依赖性细胞毒性、抗体依赖性细胞吞噬作用和无交联直接诱导细胞凋亡 (apoptosis)。Isatuximab 还直接抑制 CD38 胞外酶活性，这与许多细胞功能有关。
Isatuximab is a monoclonal antibody that targets the transmembrane receptor and the extracellular enzyme CD38, a protein highly expressed in malignant cells of the blood system, including multiple myeloma. Isatuximab has antitumor activity through a variety of biological mechanisms, including antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cytophagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 extracellular enzyme activity, which is associated with many cellular functions.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Isatuximab (anti-CD38) (Ab169280) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD38 (red) with Isatuximab (anti-CD38) (Ab169280). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Isatuximab (anti-CD38) (Ab169280) - SEC
The purity of Isatuximab (anti-CD38) (Ab169280) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F1012823 |
分析证书 | Ab169280 |
| ZJ24F1012824 |
分析证书 | Ab169280 |
| ZJ26F0636257 |
分析证书 | Ab169280 |
| ZJ23F1001244 |
分析证书 | Ab169280 |
| ZJ23F1001245 |
分析证书 | Ab169280 |
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