| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175995-100μg |
100μg |
现货  |
| |
| Ab175995-1mg |
1mg |
现货 |
| |
| Ab175995-5mg |
5mg |
现货 |
| |
| Ab175995-10mg |
10mg |
期货 |
|
| 产品名称 | Lemzoparlimab (anti-CD47) |
|---|---|
| 别名 | 莱姆佐帕单抗（抗 CD47） |
| 英文别名 | Antigenic surface determinant protein OA3 | IAP | Integrin-associated protein | Protein MER6 |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | CD47 |
| 种属反应性 | 人(Human),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG4SP |
| 轻链亚型 | kappa |
| SDS-PAGE | 26.6 kDa (Light Chain) & 51.3 kDa (Heavy Chain), under reducing conditions; 179.1 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 2377483-71-9 |
| 分子类型 | 抗体 |
Lemzoparlimab (anti-CD47) (Ab175995) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD47 with Lemzoparlimab (anti-CD47) (Ab175995) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Lemzoparlimab (anti-CD47) (Ab175995) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD47 (red) with Lemzoparlimab (anti-CD47) (Ab175995) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Lemzoparlimab (anti-CD47) (Ab175995) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD47 (red) with Lemzoparlimab (anti-CD47) (Ab175995). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Lemzoparlimab (anti-CD47) (Ab175995) - Flow Cytometry
Flow Cytometry analysis of HEK-293 cells labelling CD47 (red) with Lemzoparlimab (anti-CD47) (Ab175995). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Lemzoparlimab (anti-CD47) (Ab175995) - SEC
The purity of Lemzoparlimab (anti-CD47) (Ab175995) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1214895 |
分析证书 | 24-12-05 | Ab175995 |
| ZJ24F1214894 |
分析证书 | 24-12-05 | Ab175995 |
| ZJ24F1214893 |
分析证书 | 24-12-05 | Ab175995 |
| ZJ23F1202083 |
分析证书 | 23-12-20 | Ab175995 |
| ZJ23F1202082 |
分析证书 | 23-12-20 | Ab175995 |
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| 1. Kauder SE, Kuo TC, Harrabi O, Chen A, Sangalang E, Doyle L, Rocha SS, Bollini S, Han B, Sim J et al.. (2018) ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile.. PLoS One, 13 (8): (e0201832). [PMID:30133535] [10.1021/op500134e] |
| 2. Petrova PS, Viller NN, Wong M, Pang X, Lin GH, Dodge K, Chai V, Chen H, Lee V, House V et al.. (2017) TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding.. Clin Cancer Res, 23 (4): (1068-1079). [PMID:27856600] [10.1021/op500134e] |
| 3. Campbell, I G IG, Freemont, P S PS, Foulkes, W W and Trowsdale, J J.. (1992) An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.. Cancer research, (1): [PMID:1394148] |
| 4. Lindberg, F P FP, Gresham, H D HD, Schwarz, E E and Brown, E J EJ.. (1993) Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding.. The Journal of cell biology, [PMID:7691831] |
| 5. Mawby, W J WJ, Holmes, C H CH, Anstee, D J DJ, Spring, F A FA and Tanner, M J MJ.. (1994) Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3.. The Biochemical journal, (1): [PMID:7998989] |
| 6. Gao, A G AG and 5 more authors.. (1996) Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin.. The Journal of biological chemistry, (5): [PMID:8550562] |
| 7. Wu, A L AL, Wang, J J, Zheleznyak, A A and Brown, E J EJ.. (1999) Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.. Molecular cell, [PMID:10549293] |
| 8. Rebres, R A RA, Vaz, L E LE, Green, J M JM and Brown, E J EJ.. (2001) Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains.. The Journal of biological chemistry, (14): [PMID:11454874] |
| 9. Latour, S S and 11 more authors.. (2001) Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:11509594] |
| 10. Piccio, Laura L and 7 more authors.. (2005) Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.. Blood, (15): [PMID:15383453] |
| 11. Manna, Partha P PP, Dimitry, Julie J, Oldenborg, Per-Arne PA and Frazier, William A WA.. (2005) CD47 augments Fas/CD95-mediated apoptosis.. The Journal of biological chemistry, (19): [PMID:15917238] |
| 12. Hatherley, Deborah D and 5 more authors.. (2008) Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.. Molecular cell, (25): [PMID:18657508] |
| 13. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973] |
| 14. De Oliveira, S S, Vitorino de Almeida, V V, Calado, A A, Rosário, H S HS and Saldanha, C C.. (2012) Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane.. Biochimica et biophysica acta, [PMID:22079249] |
| 15. Rogers, Natasha M NM and 24 more authors.. (2017) TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.. Cardiovascular research, [PMID:27742621] |
| 16. Ghimire, Kedar and 11 more authors.. (2020) CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.. Cells, (15): [PMID:32679764] |
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