ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Letaplimab (anti-CD47) 是一种人源 IgG4SP 单克隆抗 CD47 抗体。CD47 在癌细胞中过表达，是 SIRPα 的配体。Letaplimab (anti-CD47) 增强肿瘤细胞吞噬作用。
Letaplimab (anti-CD47) is a human IgG4SP anti-CD47 monoclonal antibody. CD47 is overexpressed on cancer cells, it is a ligand for SIRPα. Letaplimab (anti-CD47) enhances tumor cell phagocytosis.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Letaplimab (anti-CD47) (Ab190155) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling CD47 (red) with Letaplimab (anti-CD47) (Ab190155) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Letaplimab (anti-CD47) (Ab190155) - ELISA
Immobilized Recombinant Human CD47 protein (rp144028) at 1.0 μg/mL can bind Letaplimab (anti-CD47) (Ab190155) with the EC
₅₀
of 182.6 ng/mL.
Letaplimab (anti-CD47) (Ab190155) - SEC
The purity of Letaplimab (anti-CD47) (Ab190155) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0910730 |
分析证书 | Ab190155 |
| ZJ24F0910731 |
分析证书 | Ab190155 |
| ZJ24F0910732 |
分析证书 | Ab190155 |
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