ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Bleselumab (anti-CD40) 是一种人抗-CD40 单克隆抗体 (mAb)。Bleselumab (anti-CD40) 以高亲和力结合人 CD40 (Kd: 0.24 nM)。Bleselumab (anti-CD40) 通过阻断 CD40 与其配体 CD40L 的相互作用来抑制免疫反应。Bleselumab (anti-CD40) 可预防器官移植排斥反应。
Bleselumab (anti-CD40) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab (anti-CD40) binds to human CD40 with high affinity (Kd: 0.24 nM). Bleselumab (anti-CD40) inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab (anti-CD40) prevents organ transplant rejection.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Bleselumab (anti-CD40) (Ab182780) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 with Bleselumab (anti-CD40) (Ab182780) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Bleselumab (anti-CD40) (Ab182780) - SEC
The purity of Bleselumab (anti-CD40) (Ab182780) is more than 95% verified by HPLC.
Bleselumab (anti-CD40) (Ab182780) - ELISA
Immobilized Recombinant Human CD40 protein (rp144000) at 1.0 μg/mL can bind Bleselumab (anti-CD40) (Ab182780) with the EC50 of 27.51 ng/mL.
Bleselumab (anti-CD40) (Ab182780) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Bleselumab (anti-CD40) (Ab182780). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Bleselumab (anti-CD40) (Ab182780) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 (red) with Bleselumab (anti-CD40) (Ab182780) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Bleselumab (anti-CD40) (Ab182780) - Flow Cytometry
Flow Cytometry analysis of U-2 OS cells labelling CD40 (red) with Bleselumab (anti-CD40) (Ab182780). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0505997 |
分析证书 | Ab182780 |
| ZJ24F0505998 |
分析证书 | Ab182780 |
| ZJ24F0505999 |
分析证书 | Ab182780 |
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