ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Lucatumumab (anti-CD40) 是一种全人抗 CD40 拮抗剂单克隆抗体，可阻断 CD40/ CD40L 介导的信号通路。Lucatumumab (anti-CD40) 可有效介导抗体依赖性细胞介导的细胞毒性 (ADCC) 和肿瘤细胞清除，可用于顽固性淋巴瘤、慢性淋巴细胞白血病 (CLL) 和多发性骨髓瘤研究。
Lucatumumab (anti-CD40) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab (anti-CD40) efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Lucatumumab (anti-CD40) (Ab183426) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 with Lucatumumab (anti-CD40) (Ab183426) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Lucatumumab (anti-CD40) (Ab183426) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 (red) with Lucatumumab (anti-CD40) (Ab183426) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Lucatumumab (anti-CD40) (Ab183426) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Lucatumumab (anti-CD40) (Ab183426). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Lucatumumab (anti-CD40) (Ab183426) - ELISA
Immobilized Recombinant Human CD40 protein (rp183577) at 1.0 μg/mL can bind Lucatumumab (anti-CD40) (Ab183426) with the EC₅₀ of 56.96 ng/mL.
Lucatumumab (anti-CD40) (Ab183426) - SEC
The purity of Lucatumumab (anti-CD40) (Ab183426) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0910141 |
分析证书 | Ab183426 |
| ZJ24F0910142 |
分析证书 | Ab183426 |
| ZJ24F0910143 |
分析证书 | Ab183426 |
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