ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Enavatuzumab (anti-TWEAKR) 是一种人源化 IgG1 单克隆抗体，靶向 TNF 样细胞凋亡弱诱导剂受体 (TWEAK)。TWEAK (Fn14; TNFRSF12A) 是 TWEAK 受体 (TweakR) 的天然配体，可刺激多种细胞反应。Enavatuzumab (anti-TWEAKR) 通过直接的 TweakR 信号和抗体依赖性细胞介导的细胞毒性 (ADCC) 诱导肿瘤生长抑制。Enavatuzumab (anti-TWEAKR) 可以主动募集和激活骨髓效应细胞来杀死肿瘤细胞。Enavatuzumab (anti-TWEAKR) 在体外和体内抑制各种人类 TweakR 阳性癌细胞系和异种移植物的生长。
Enavatuzumab (anti-TWEAKR) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab (anti-TWEAKR) induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab (anti-TWEAKR) can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab (anti-TWEAKR) inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Enavatuzumab (anti-TWEAKR) (Ab183422) - Flow Cytometry
Flow Cytometry analysis of HT-29 cells labelling TWEAKR (red) with Enavatuzumab (anti-TWEAKR) (Ab183422). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Enavatuzumab (anti-TWEAKR) (Ab183422) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling TWEAKR (red) with Enavatuzumab (anti-TWEAKR) (Ab183422). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Enavatuzumab (anti-TWEAKR) (Ab183422) - SEC
The purity of Enavatuzumab (anti-TWEAKR) (Ab183422) is more than 95% verified by HPLC.
Enavatuzumab (anti-TWEAKR) (Ab183422) - Flow Cytometry
Transfected with Human TWEAKR protein of HEK293 cells were stained with Enavatuzumab (anti-TWEAKR) (Ab183422) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, the EC50 for this effect is 46.94 nM.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F1013156 |
分析证书 | Ab183422 |
| ZJ24F1013157 |
分析证书 | Ab183422 |
| ZJ24F1013158 |
分析证书 | Ab183422 |
| ZJ24F0505694 |
分析证书 | Ab183422 |
| ZJ24F0505696 |
分析证书 | Ab183422 |
| ZJ24F0505700 |
分析证书 | Ab183422 |
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