Celecoxib

概述规格名称和识别符技术文档高级数据系统学分类三维结构产品属性质检证书（CoA,COO,BSE/TSE 和分析图谱) 化学和物理性质安全和危险性（GHS）此产品的引用文献技术文档和文章引用文献溶液计算器常见问题

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为什么选择此级别

，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

室温。常规运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 42 篇同行评审文献引用。

概述

Celecoxib (GMP) 是 GMP 级别的 Celecoxib。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Celecoxib 是一种选择性的 COX-2 抑制剂，IC50 为 40 nM。

Celecoxib (GMP) is Celecoxib produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM.

规格

英文名称

Celecoxib

储存条件

室温

运输条件

常规运输

名称和识别符

EC号

685-962-5

分子类型

小分子

IUPAC Name

4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

INCHI

1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)

InChi Key

RZEKVGVHFLEQIL-UHFFFAOYSA-N

Smiles

CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

Isomeric SMILES

CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

关联CAS

169590-42-5

NSC Number

719627

MeSH Entry Terms

4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide;Celebrex;celecoxib;SC 58635;SC-58635;SC58635

分子量

381.37

Reaxy-Rn

7662430

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7662430&ln=

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

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📊 产品数据表

产品规格和应用的快速参考摘要。

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🔬 规格说明书

该级别的完整质量属性和验收标准。

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高级数据

系统学分类

分类树（Taxonomy Tree）

界（kingdom) 有机化合物
- 超类（Superclass) 有机杂环化合物
  - 类（Class) 唑类
    - 亚类（Subclass）吡唑类

界（kingdom)	有机化合物
超类（Superclass)	有机杂环化合物
类（Class)	唑类
亚类（Subclass）	吡唑类
中间层级节点（Intermediate Tree Nodes）	暂无
直接上位类(Direct Parent)	苯基吡唑类
其他上位类（Alternative Parents）	苯磺酰胺类苯磺酰基化合物甲苯有机磺酰胺杂芳族化合物氨基磺酰基化合物氮杂环化合物有机光子化合物有机氮化合物有机氟化物有机氧化物碳氢化合物衍生物烷基氟化物
分子骨架（Molecular Framework)	芳香族杂单环化合物
取代基（Substituents）	氟化烷基 - 烷基溴化物 - 氨基磺酰基化合物 - 芳香族杂单环化合物 - 氮杂环 - 苯磺酰胺 - 苯磺酰基 - 苯基化合物 - 杂芳香族化合物 - 烃衍生物 - 单环苯基基团 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机磺酸或其衍生物 - 有机氟化物 - 有机卤化物 - 有机氮化合物 - 有机氮化合物 - 有机硫酰胺 - 有机磺酸或其衍生物 - 有机硫化合物 - 苯基吡唑 - 磺酰基 - 甲苯
描述（Description）	该化合物属于苯基吡唑类有机化合物。这类化合物具有苯基吡唑骨架，即吡唑基团与苯基相连的结构。
外部描述符（External Descriptors）	organofluorine compound - pyrazoles - sulfonamide

三维结构

交互式化学结构模型

球棍
棍棒
线框模型
空间填充
显示氢气
动画

产品属性

ALogP	3.4

化学和物理性质

熔点

163 °C

安全和危险性（GHS）

象形图

GHS08

信号词

危险

危险声明

H360: 可能损害生育力或未出生的孩子

H373: 通过长时间或反复暴露对器官造成损害

H401: 对水生生物有毒

H410: 对水生生物有剧毒并具有长期持续影响

预防措施声明

P201: 使用前获取特殊说明

P202: 在阅读并理解所有安全预防措施之前，不要进行操作。

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P273: 避免释放到环境中。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P391: 收集溢出物

P308+P313: 如接触到或有疑虑：求医/就诊。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

WGK Germany

RTECS

DB2944937

Merck Index

1956

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

非甾体抗炎药

目录：技术文章

探索主题:

抗癌抗炎药

Non-Steroidal Anti-Inflammatory Drugs

目录：技术文章

探索主题:

Anti-cancer Anti-inflammatory drugs

GMP

目录：阿拉丁试剂的规格、级别和纯度

探索主题:

GMP

目录：阿拉丁试剂的规格、级别和纯度

探索主题:

GMP

NSAIDs非甾体抗炎药：COX机制、风险速查及科研选型指南-附阿拉丁产品清单

目录：技术文章

探索主题:

非甾体抗炎药 NSAIDs

NSAIDs (Nonsteroidal Anti-inflammatory Drugs): COX Mechanism, Risk Quick Reference, and Research Selection Guide — with an Aladdin Product List

目录：技术文章

探索主题:

NSAIDs Nonsteroidal Anti-inflammatory Drugs

吡唑科研路线图：双氮结构特征、典型应用与选型分类导航（表1–表4）

目录：技术文章

探索主题:

吡唑吡唑类

Pyrazole Research Roadmap: Dual-Nitrogen Structural Features, Typical Applications, and Selection-Oriented Classification Navigation (Tables 1–4)

目录：技术文章

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Pyrazole Pyrazoles

认识有机氟杂环化合物：结构调控、应用场景、科研选型与产品导航（表1–表5）

目录：技术文章

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氟有机氟杂环化合物

Understanding Organofluorine Heterocycles: Structure Tuning, Applications, Research Selection, and Product Navigation (Tables 1-5)

目录：技术文章

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Fluorine Organofluorine heterocycles

炎症信号通路研究指南：危险信号识别、核心信号模块、检测指标与代表性研究试剂

目录：技术文章

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炎症反应炎症信号

Inflammatory Signaling Pathway Research Guide: Danger Signal Recognition, Core Signaling Modules, Detection Readouts, and Representative Research Reagents

目录：技术文章

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Inflammatory Response inflammatory signaling

油橄榄叶提取物用于皮肤泛红护理的科学依据与应用评估

目录：技术文章

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血管扩张感觉神经兴奋炎症介质增加氧化应激和屏障受损

Scientific Rationale and Application Assessment of Olive Leaf Extract in Skin Redness Care

目录：技术文章

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vasodilation Sensory nerve activation

三种四元环锍盐模块化构建九类螺[2.3]己烷骨架：合成方法与生物电子等排体评价

目录：技术文章

探索主题:

己烷骨架

Modular Construction of Nine Classes of Spiro[2.3]hexane Scaffolds Using Three Four-Membered-Ring Sulfonium Salts: Synthetic Methodology and Bioisosteric Evaluation

目录：技术文章

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Hexane skeleton

Hippo信号通路的分子组成、信号传递机制与靶向调控策略

目录：技术文章

探索主题:

机械转导 Hippo信号通路 YAP TAZ TEAD MST1/2 LATS1/2 靶向策略

Molecular Composition, Signal Transduction Mechanisms, and Targeted Regulatory Strategies of the Hippo Signaling Pathway

目录：技术文章

探索主题:

mechanotransduction YAP TAZ TEAD MST1/2 LATS1/2 Hippo signaling pathway targeting strategies

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Yongjing Cao, Juan Li, Qiangwei Liang, Jiayu Yang, Xiaojie Zhang, Juntao Zhang, Min An, Jiawei Bi, Yanhua Liu. (2023) Tumor Microenvironment Sequential Drug/Gene Delivery Nanosystem for Realizing Multistage Boosting of Cancer–Immunity Cycle on Cancer Immunotherapy. ACS Applied Materials & Interfaces, [PMID:37963093] [10.1021/acsami.3c11394]
2. Xiaoyu Han, Fan Wang, Jieliang Shen, Shuyu Chen, Pengcheng Xiao, Ying Zhu, Weiwei Yi, Zhengyu Zhao, Zhengwei Cai, Wenguo Cui, Dingqun Bai. (2023) Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep-Layer Drug Delivery. ADVANCED MATERIALS, [PMID:37851922] [10.1002/adma.202306993]
3. Shouchao Xu, Jiehong Yang, Haitong Wan, Li Yu, Yu He. (2023) Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2126). [PMID:36768450] [10.3390/ijms24032126]
4. Chen An, Cai Peishan, Luo Minqian, Guo Minshan, Cai Ting. (2022) Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs. PHARMACEUTICAL RESEARCH, 40 (2): (567-577). [PMID:36348133] [10.1007/s11095-022-03427-3]
5. Xin Zhao, Lingyu Li, Shuang Li, Jinyu Liu, Hongya Wang, Yulin Lin, Dayong Cai. (2022) Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:35738453] [10.1016/j.ejphar.2022.175115]
6. Cong Zhang, Yuzhen Lu, Yingying Song, Liang Chen, Junjie Hu, Yan Meng, Xin Chen, Shan Li, Guohua Zheng, Zhenpeng Qiu. (2022) Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt-dependent lipogenic pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 26 (14): (3995-4006). [PMID:35713152] [10.1111/jcmm.17435]
7. Jialiang Lin, Junchao Huang, Jiang Wu, Bo Tang, Congbin Li, Haijun Xiao. (2022) Poly(lactic acid-co-glycolic acid)-based celecoxib extended-release microspheres for the local treatment of traumatic heterotopic ossification. JOURNAL OF BIOMATERIALS APPLICATIONS, [PMID:35043696] [10.1177/08853282211056937]
8. Changyou Yu, Menghui Yao, Yiming Ma, Yanbo Liu, Shilin Guo, Shijie Xu, Sohrab Rohani, Mingyang Chen, Junbo Gong. (2021) Design of the spherical agglomerate size in crystallization by developing a two-step bridging mechanism and the model. AICHE JOURNAL, 68 (2): (e17526). [10.1002/aic.17526]
9. Muhammad Asim Farooq, Amna Jabeen, Bo Wang. (2021) Formulation, optimization, and characterization of whey protein isolate nanocrystals for celecoxib delivery. JOURNAL OF MICROENCAPSULATION, [PMID:33896352] [10.1080/02652048.2021.1915398]
10. Wei Gu, Qinfu Zhao, Ye He, Shengyu Wang, Yuanqi Yang, Yian Li, Shuaipeng Feng, Siling Wang. (2024) Different mesoporous carbon carriers for the improvement of solubility and physical stability of poorly soluble drugs. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:39705828] [10.1016/j.colsurfb.2024.114436]
11. Zixinying Han, Chenxu Liu, Mingrui Li, Mengyan Deng, Ying Ding, Yunchao Li, Meidan Huo, Haiwei Xu, Hailing Qiao, Na Gao. (2024) Discovery of CYP2E1 as a novel target in rheumatoid arthritis and validation by a new specific CYP2E1 inhibitor. BIOCHEMICAL PHARMACOLOGY, [PMID:39173843] [10.1016/j.bcp.2024.116501]
12. Zhang Xiaojie, Liang Qiangwei, Cao Yongjin, Yang Ting, An Min, Liu Zihan, Yang Jiayu, Liu Yanhua. (2024) Dual depletion of myeloid-derived suppressor cells and tumor cells with self-assembled gemcitabine-celecoxib nano-twin drug for cancer chemoimmunotherapy. JOURNAL OF NANOBIOTECHNOLOGY, 22 (1): (1-19). [PMID:38849938] [10.1186/s12951-024-02598-y]
13. Minqian Luo, An Chen, Chengbin Huang, Minshan Guo, Ting Cai. (2024) Effects of Polymers on Cocrystal Growth in a Drug–Drug Coamorphous System: Relations between Glass-to-Crystal Growth and Surface-Enhanced Crystal Growth. MOLECULAR PHARMACEUTICS, [PMID:38818946] [10.1021/acs.molpharmaceut.4c00315]
14. Huang Lin, Wang Wantao, Liu Lei, Ma Wenzheng, Fan Jinghao, Zhou Dan, Zhao Lei, Zheng Zhaomin, Liu Hongmei, Wu Decheng. (2025) Injectable chitosan microspheres resisting inflammatory and oxidative stress for ameliorating intervertebral disc degeneration. Science China-Materials, [10.1007/s40843-024-3153-8]
15. Xianquan Feng, Lingjun Zeng, Lina Wu, Zhenzhen Chen, Wanjing Lin, Hongtao Song, Fenghua Lan. (2024) Self-delivery nanodrug to manipulate tumor microenvironment for boosting photodynamic cancer immunotherapy. BIOMEDICINE & PHARMACOTHERAPY, [PMID:39094543] [10.1016/j.biopha.2024.117220]
16. Cuiping Long, Qian Zhou, Min Xu, Xin Ding, Xingxing Zhang, Ya Zhang, Yuping Tang, Guangguo Tan. (2024) Sini Decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism. Chinese Herbal Medicines, [PMID:39949807] [10.1016/j.chmed.2023.12.004]
17. Wenqing Sun, Yufeng Xu, Zhiqin Liu, Wei Liu, Hongting Wang, Guanyu Chang, Zihui Yang, Zhen Dong, Jianguo Zeng. (2024) Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ. TOXICOLOGY MECHANISMS AND METHODS, [PMID:39087424] [10.1080/15376516.2024.2383366]
18. Xiaoxiang Cheng, Zhe Xu, Xinsheng Luo, Yi Chai, Jiajian Xing, Xinyu Zhang, Jingtao Xu. (2025) Self-limiting interfacial synthesis of inorganic thin films for high-performance organic solvent nanofiltration in pharmaceutical applications. SEPARATION AND PURIFICATION TECHNOLOGY, [10.1016/j.seppur.2025.134261]
19. Xiaoliang Deng, Xianquan Feng, Xiaohui Tang, Zhihui Zheng, Da Zheng, Enqin Zheng, Lingjun Zeng, Shiying Xu, Boxin Chen, Qian Zhang, Zhihong Liu, Hongtao Song. (2025) Self-Delivery Nanotherapeutics for Tumor Low-Temperature Photothermal Immunotherapy through Cascade Heat Shock Protein and Inflammation Inhibition. ACS Applied Materials & Interfaces, [PMID:40735962] [10.1021/acsami.5c10905]
20. Mingyue Yin, Xinyi Xiao, Yang Xiao, Jingyan Zhou, Shuxian Liu, Xue Jiang, Xiaomin Han, Tao Zhuang, Yin Chen. (2025) Discovery of two new co-drugs of celecoxib and gabapentinoids for treating chemotherapy-induced peripheral neuropathy. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:40618982] [10.1016/j.ejphar.2025.177919]
21. Mengyang Cai, Pengpeng Yang, Jinqiu Fu, Guiyu Chen, Keke Zhang. (2025) Insights into the Effect of Nanoconfinement Surface Chemistry on Celecoxib Aggregation and Dissolution by 19F NMR Spectroscopy. CRYSTAL GROWTH & DESIGN, [10.1021/acs.cgd.5c00656]
22. Hong Tang, Qi Dai, Ziyan Zhao, Weiye Ge, Danlei Li, Zelin Chang, Penglai Pi, Jia Li, Zheng Sun. (2025) Melatonin Synergises the Chemotherapeutic Effect of Temozolomide in Glioblastoma by Suppressing NF-κB/COX-2 Signalling Pathways. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 29 (15): (e70778). [PMID:40804775] [10.1111/jcmm.70778]
23. Shiying Xu, Lina Wu, Boxin Chen, Xiaoliang Deng, Zhihui Zheng, Fei Wu, Lingjun Zeng, Changqing Zheng, Xiaomu Hu, Aiwen Huang, Xin Zhou, Xianquan Feng, Zhihong Liu. (2025) A self-delivery albumin nanomedicine amplified photodynamic therapy against esophageal cancer through COX-2/PGE2 interruption and regulation of mitochondrial respiratory. International Journal of Pharmaceutics-X, [PMID:41089759] [10.1016/j.ijpx.2025.100407]
24. Xiangyun Tan, Yuan Yang, Junjie Hu, Yan Meng, Liang Chen, Guohua Zheng, Han Xiao, Zhenpeng Qiu. (2025) Celecoxib blocks AKT/mTOR in AKT/YapS127A-driven intrahepatic cholangiocarcinoma, activating p21/p27 for cycle arrest and suppressing Mcl-1 for apoptosis. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:40930397] [10.1016/j.cbi.2025.111737]
25. Yue Wang, Chen Wei, Xiaoyu Zhao, Fantao Lin, Shijie Liu, Jingkun Bai. (2025) A pH-sensitive peptide amphiphilic-based drug delivery system inhibits hepatocellular carcinoma growth by suppressing hepatic stellate cell activation. Materials Today Bio, [PMID:40453820] [10.1016/j.mtbio.2025.101821]
26. Xianbang Hou, Ran Chen, Juan Wu, Yujie Huang, Xueyuan Zhang, Shaobao Xu, Liwei He. (2025) Selective COX-2 inhibitors from natural sources: Insights from the analysis of components absorbed into blood from Isatidis Radix Lignans. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40354841] [10.1016/j.jep.2025.119930]
27. Wenling Zheng, Junni Ke, Kaerdun Liu, Rongrong Xue, Fenghua Chen. (2025) Aqueous Solution Spray Drying Preparations of Binary Amorphous Solid Dispersions. Crystals, 15 (4): (323). [10.3390/cryst15040323]
28. Minqian Luo, An Chen, Shiyu Shan, Minshan Guo, Ting Cai. (2025) Molar Ratio-Dependent Crystallization in Coamorphous Celecoxib–Carbamazepine Systems: The Interplay of Thermodynamics and Kinetics. MOLECULAR PHARMACEUTICS, [PMID:40360458] [10.1021/acs.molpharmaceut.5c00278]
29. Hong-Fu Zhao, Si-Yi Han, Lu Xiao, Bo-Kang Yu, Ning Xia, Ying-Hua Zhang. (2025) Ultrasound-assisted extraction of anti-inflammatory actives from corn silk (Zea mays L.): process optimization, machine learning screening, and interaction mechanisms. ULTRASONICS SONOCHEMISTRY, [PMID:40577999] [10.1016/j.ultsonch.2025.107420]
30. Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen. (2025) HIFU-Driven Targeted Pyroptosis Therapy in Basal-Like Breast Cancer. Advanced Science, [PMID:40946176] [10.1002/advs.202503830]
31. Dong-Wei Shao, Tong Xie, Ya-Tao Wang. (2025) A pH-responsive injectable hydrogel that modulates the inflammatory microenvironment for the treatment of osteoarthritis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:41176002] [10.1016/j.ijbiomac.2025.148686]
32. Xin Zhao, Shibin Han, Cheng Chen, Xiaoyi Lv, Jiahe Li, Chen Chen. (2025) Deep learning-assisted SERS platform for label-free detection of celecoxib in serum using ag@Pt@porous silicon Bragg mirror composite substrate. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:41242102] [10.1016/j.saa.2025.127165]
33. Lei Yu, Bai Yaowei, Bai Xiatong, Sun Bo, Zhu Licheng, Wu Wenlong, Su Yang, Zhang Hongsen, Wang Yingliang, Zheng Chuansheng. (2025) COX-2/PGE2 axis blockade with celecoxib enhances anti-PD-1 efficacy by activating natural killer cells for residual hepatocellular carcinoma after radiofrequency ablation. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 44 (1): (321). [PMID:41408296] [10.1186/s13046-025-03582-6]
34. Xianquan Feng, Yan Zhang, Wanjing Lin, Jing Li, Fei Wu, Qingyu Lu, Hongtao Song, Hao Zhang, Fenghua Lan, Jun Lu. (2025) A Self-Amplifying Photodynamic Biomedicine for Cascade Immune Activation Against Triple-Negative Breast Cancer. Small, [PMID:39846288] [10.1002/smll.202410214]
35. Zhiling Chen, Huiling Zhou, Jie Song, Ben Xu, Can Wang, Fengchun He, Guisen Zhang, Tao Zhuang. (2026) A new drug-drug co-amorphous system of imipramine and celecoxib with improved solubility and synergistic antinociceptive effects. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, [PMID:41519309] [10.1016/j.ejpb.2026.114988]
36. Shuang Wang, Tianwu Chen, Yong Li, Lei Zhang, Jing Wang, Changsheng Liu. (2026) Friction-Adaptive Hydrogel Coating for Mechanical-Immune Synergy in Ligament-to-Bone Integration. BIOMATERIALS, [PMID:41633300] [10.1016/j.biomaterials.2026.124003]
37. Aoyu Zhang, Shuying Li, Jie Qiao, Chuanqi Zhong, Zhiwen Zhang, Xiguang Ye, Jun Jin, Shiyan Shang, Song Wu, Qing Zhang, Gongxu Yang. (2026) Isopsoralen alleviates osteoarthritis by modulating the MAPK/NF-κB signaling pathway and regulating the structure of gut microbiota. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:41628870] [10.1016/j.jep.2026.121257]
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