Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
宿主种属
兔(Rabbit)
特异性
CD68
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse),猴(Monkey)
免疫原
A KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD68.
阳性对照
WB: Rat spleen, lung lysates. IHC: Human skin tissue.
CD68 Antibody (Ab095179) - Western Blot All lanes: CD68 Antibody (Ab095179) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/30000 dilution
Predicted band size: 37 kDa Observed band size: 62, 79 kDa Exposure time: 99.0 s
CD68 Antibody (Ab095179) - IHC Immunohistochemical analysis of CD68 staining in human skin formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with CD68 Antibody (Ab095179) at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.