Rabbit anti Human DDB2 Antibody, Recombinant, could be used for WB and so on.
规格
产品名称
Recombinant DDB2 Antibody
别名
损伤特异性DNA结合蛋白2抗体 | 损伤特异性DNA结合蛋白2重组单克隆抗体 | DDB2抗体 | DDB2重组单克隆抗体 | DNA damage binding protein 2抗体 | DNA damage binding protein 2重组单克隆抗体
英文别名
Damage-specific DNA binding protein 2 antibody | Damage-specific DNA-binding protein 2 antibody | DDB p48 subunit antibody | Ddb2 antibody | DDB2_HUMAN antibody | DDBb antibody | DNA damage-binding protein 2 antibody | UV-damaged DNA-binding protein 2 ant
规格或纯度
重组,ExactAb™,已验证,见COA
生化机理
Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
宿主种属
兔(Rabbit)
特异性
DDB2
种属反应性
人(Human)
免疫原
A synthetic peptide derived from human DDB2 (AA 350-427).
阳性对照
WB: HeLa, Raji, MCF7, A431 and Hep G2 cell lysates.
Recombinant DDB2 Antibody (Ab099353) - Western Blot All lanes: Recombinant DDB2 Antibody (Ab099353) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 48 kDa Observed band size: 39, 42 kDa Exposure time: 6.0 s
ZJ26F0434277
危险品化学品经营许可证（带存储）