Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
宿主种属
兔(Rabbit)
特异性
KLK11
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Kallikrein 11.
Kallikrein 11 Antibody (Ab111626) - Western Blot All lanes: Kallikrein 11 Antibody (Ab111626) at 1/500 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution Predicted band size: 31 kDa Observed band size: 15, 17, 51 kDa About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen (PMID: 16467084). Exposure time: 91.7 s