Protein Function
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
宿主种属
兔(Rabbit)
特异性
NRP1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Neuropilin 1 (AA 900-923)
Recombinant Neuropilin 1 Antibody (Ab117770) - Western Blot All lanes: Recombinant Neuropilin 1 Antibody (Ab117770) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/30000 dilution
Predicted band size: 103 kDa Observed band size: 124 kDa Exposure time: 16.7 s
Recombinant Neuropilin 1 Antibody (Ab117770) - Western Blot All lanes: Recombinant Neuropilin 1 Antibody (Ab117770) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/30000 dilution
Predicted band size: 103 kDa Observed band size: 124 kDa Exposure time: 174.0 s
Recombinant Neuropilin 1 Antibody (Ab117770) - Western Blot All lanes: Recombinant Neuropilin 1 Antibody (Ab117770) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/30000 dilution
Predicted band size: 103 kDa Observed band size: 124 kDa Exposure time: 100.0 s
ZJ24F0606705
危险品化学品经营许可证（带存储）