Adult T cell leukemia derived PMA responsive antibody | APR antibody | APR_HUMAN antibody | ATL-derived antibody | Immediate early response protein APR antibody | Immediate-early-response protein APR antibody | NOXA antibody | Phorbol 12 myristate 13 acet
规格或纯度
重组, ExactAb™, 已验证, 高性能, 见COA
生化机理
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
宿主种属
兔(Rabbit)
特异性
PMAIP1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Noxa (AA 31-44).
Recombinant Noxa Antibody (Ab118565) - Western Blot All lanes: Recombinant Noxa Antibody (Ab118565) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 6 kDa Observed band size: 14 kDa NOXA can form a complex of approximately 32 kDa with pHSP27. The cross-linking of Noxa and p-HSP27 is essential for blocking NF-kB activation.(PMID:29363670) Exposure time: 25.9 s
ZJ24F0607073
危险品化学品经营许可证（带存储）