Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
宿主种属
兔(Rabbit)
特异性
Peroxiredoxin 1/PAG
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Peroxiredoxin 1/PAG (AA 186-199).
阳性对照
WB: Mouse brain tissue lysate, C6, NIH/3T3, A431, Hep G2, MCF7, K562, A549 and HeLa cell lysates. ICC/IF: HeLa cells.
Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313) - Western Blot All lanes: Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 22 kDa Observed band size: 24 kDa Exposure time: 10.0 s
Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313) - IF/ICC Immunocytochemistry analysis of Peroxiredoxin 1 (green) in HeLa using Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313), and cells were counterstained with DAPI (blue).
ZJ24F0102514
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