Rabbit anti Human Poliovirus Receptor/PVR Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/2000 Protein Function: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Recombinant Poliovirus Receptor/PVR Antibody (Ab122570) - Western Blot All lanes: Recombinant Poliovirus Receptor/PVR Antibody (Ab122570) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 45 kDa Observed band size: 71 kDa Exposure time: 150.5 s Poliovirus Receptor/PVR is a glycoprotein. The molecular weight observed is consistent with what has been described in the literature (PMID:17893876,11454801).
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