Rabbit anti Human RNase L Antibody, Recombinant, could be used for WB and so on.
Application: WB: 1/500-1/1000
Protein Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.
Recombinant RNase L Antibody (Ab125506) - Western Blot All lanes: Recombinant RNase L Antibody (Ab125506) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 84 kDa Observed band size: 81 kDa Exposure time: 11.1 s
Recombinant RNase L Antibody (Ab125506) - Western Blot All lanes: Recombinant RNase L Antibody (Ab125506) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 84 kDa Observed band size: 62 kDa Exposure time: 20.0 s