Rabbit anti Human SNF2H Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/2000 Protein Function Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
Recombinant SNF2H Antibody (Ab128479) - Western Blot All lanes: Recombinant SNF2H Antibody (Ab128479) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 122 kDa Observed band size: 132 kDa Exposure time: 9.9 s
SMARCA5TbioSWI/SNF 相关基质相关肌动蛋白依赖性染色质调节亚家族 A 成员 5(SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5)
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