APRFMGC16063 | DNA-binding protein APRF | FLJ20882 | HIES | signal transducer and activator of transcription 3 (acute-phase responsefactor) | signal transducer and activator of transcription 3 | STAT3 | 1110034C02Rik antibody | Acute-phase response factor
规格或纯度
重组, ExactAb™, 敲低验证, 已验证, 见COA
生化机理
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
宿主种属
兔(Rabbit)
特异性
STAT3
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human STAT3 (AA 670-700)
阳性对照
WB: Mouse heart, HT-1080, HeLa, HEK293, A375, A431, NIH/3T3 and C6 lysates. IHC: Rat brain, Human astrocytoma, Human Hodgkin's lymphoma tissues. IF/ICC: HeLa cells.
Recombinant STAT3 Antibody (Ab129421) - Western Blot All lanes: Recombinant STAT3 Antibody (Ab129421) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 88 kDa Observed band size: 91 kDa Exposure time: 5.2 s
Recombinant STAT3 Antibody (Ab129421) - Western Blot All lanes use Recombinant STAT3 Antibody (Ab129421) at 1/1000 dilution for 1 hour at room temperature.
Recombinant STAT3 Antibody (Ab129421) - IF/ICC Immunofluorescent analysis of Hela cells treated with IFN alpha, using Recombinant STAT3 Antibody (Ab129421).
Recombinant STAT3 Antibody (Ab129421) - IHC Immunohistochemical analysis of paraffin-embedded Human Hodgkin's lymphoma, using Recombinant STAT3 Antibody (Ab129421) at 1/100 dilution.
Recombinant STAT3 Antibody (Ab129421) - IHC Immunohistochemical analysis of paraffin-embedded Human astrocytoma, using Recombinant STAT3 Antibody (Ab129421) at 1/100 dilution.
Recombinant STAT3 Antibody (Ab129421) - IHC Immunohistochemical analysis of paraffin-embedded rat brain, using Recombinant STAT3 Antibody (Ab129421).
ZJ24F0708504
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