Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33.
宿主种属
兔(Rabbit)
特异性
USP9X
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthesized peptide derived from human USP9x (AA 1-58)
Recombinant USP9X Antibody (Ab133787) - Western Blot All lanes: Recombinant USP9X Antibody (Ab133787) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 290 kDa Observed band size: 262 kDa Exposure time: 10.1 s