Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
宿主种属
兔(Rabbit)
特异性
Vitamin D Receptor
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Vitamin D Receptor (AA 5-31)
阳性对照
WB: HeLa, THP-1, MCF7, L929 and HT-29 cell lysates.
Recombinant Vitamin D Receptor Antibody (Ab134310) - Western Blot All lanes: Recombinant Vitamin D Receptor Antibody (Ab134310) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 48 kDa Observed band size: 47 kDa Exposure time: 143.8 s