Rabbit anti Human WRN Antibody, Recombinant, could be used for WB and so on. Application · WB: 1/500-1/1000 Protein Function Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A.
规格
产品名称
Recombinant WRN Antibody
别名
维尔纳综合征螺旋酶抗体 | 重组WRN抗体
英文别名
DKFZp686C2056 antibody | DNA helicase antibody | DNA helicase, RecQ like type 3 antibody | Exonuclease WRN antibody | HGNC 12791 antibody | OTTHUMP00000225301 antibody | RecQ protein-like 2 antibody | RecQ-like type 3 antibody | RecQ3 antibody | RECQL2 an
规格或纯度
ExactAb™, Validated, 重组, 2.0 mg/mL
宿主种属
兔(Rabbit)
特异性
WRN
种属反应性
人(Human)
免疫原
A synthetic peptide derived from human WRN (AA 1350-1432)
Recombinant WRN Antibody (Ab134643) - Western Blot All lanes: Recombinant WRN Antibody (Ab134643) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution Predicted band size: 162 kDa Observed band size: 189 kDa Exposure time: 100.0 s