cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING) , which activates a signaling cascade leading to the production of type I interferons and other immune mediators

In Vitro

cGAMP disodium promotes the antigen-specific proliferation capacity of spleen cells in mice. ?\ncGAMP disodium directly activates murine and human dendritic cells in vitro. ?\nOn stimulation with cGAMP disodium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF). ?\ncGAMP disodium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks oldDosage: 5 µg Administration: Nostril mucosal adjuvant Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.

Form:Solid

IC50& Target:Human Endogenous Metabolite

规格

别名

cGAMP二钠

规格或纯度

≥99%

英文名称

cGAMP disodium

生化机理

cGAMP（环状 GMP-AMPP）二钠作为一种内源性第二信使存在于变态类动物体内，可触发细胞膜 DNA 产生干扰素。

储存条件

-20°C储存,干燥

运输条件

超低温运输

作用类型

激活剂

纯度

≥99%

名称和识别符

分子类型

小分子

分子量

718.37

高级数据

化学和物理性质

溶解性

H2O : 180 mg/mL (250.57 mM; Need ultrasonic and warming)

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

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溶液计算器