计算溶液所需的质量、体积或浓度。
提供 ≥98%(HPLC) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 53 篇同行评审文献引用。
4-(N-马来酰亚胺基甲基)环己烷羧酸 N-羟基琥珀酰亚胺酯(SMCC)是一种异双功能交联剂,其包含一个具有胺和巯基反应性的延长间隔基。[1]它通常首先通过酰胺键(pH7.5(6.5-8.5)缓冲)与含有伯胺的分子进行偶联。第二次偶联通过硫醚键(pH6.8(6.5-7.0)缓冲)与含有游离巯基的分子进行特异性偶联。SMCC包含九个原子连接子。与芳族间隔基相比,延伸的脂族间隔基可在偶联之前稳定马来酰亚胺。
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
分类树(Taxonomy Tree)
| 界(kingdom) | 有机化合物 |
|---|---|
| 超类(Superclass) | 有机杂环化合物 |
| 类(Class) | 吡咯烷 |
| 亚类(Subclass) | 吡咯烷酮 |
| 中间层级节点(Intermediate Tree Nodes) | 暂无 |
| 直接上位类(Direct Parent) | 马来酰亚胺 |
| 其他上位类(Alternative Parents) | 吡咯烷-2-酮 N-取代羧酸酰亚胺 吡咯啉 二羧酰亚胺 内酰胺类 羧酸盐 一元羧酸及其衍生物 氮杂环化合物 有机光子化合物 有机氮化合物 有机盐 有机氧化物 碳氢化合物衍生物 羰基化合物 |
| 分子骨架(Molecular Framework) | 脂肪族杂单环化合物 |
| 取代基(Substituents) | 2-吡咯烷酮 - 脂肪族杂单环化合物 - 氮杂环 - 羰基 - 羧酸衍生物 - 羧酸酰亚胺 - 羧酸亚胺,正位取代 - 羧酸盐 - 二羧酰亚胺 - 烃衍生物 - 肟 - 甲酰亚胺 - 单羧酸或其衍生物 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机盐 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 - 吡咯烷酮 |
| 描述(Description) | 该化合物属于马来酰亚胺类有机化合物。这类化合物含有2,5-吡咯烷酮结构单元。 |
| 外部描述符(External Descriptors) | maleimides - N-hydroxysuccinimide ester |
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
P264: 处理后要彻底洗手。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P302+P352: 如皮肤沾染:用水充分清洗。
P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P332+P313: 如发生皮肤刺激:求医/就诊。
P337+P313: 如仍觉眼刺激:求医/就诊。
P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。
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| 批号(Lot Number) | 证书类型 | 货号 |
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| 分析证书 | N159712 |
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