Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer diseases.

Prepared from tissue shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

规格

产品名称

组织蛋白酶D 来源于人肝

英文别名

CTSD | CPSD | CLN10

规格或纯度

生物活性,ActiBioPure™,天然,高性能,EnzymoPure™,PBS Only,≥95%(SDS-PAGE),≥300 U/mg protein；冻干前浓度：见COA

生化机理

Important for the overall degradation of proteins in lysosomes. Catalytic activity: Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. Post-translational: N- and O-glycosylated. Undergoes proteolytic cleavage and activation by ADAM30.1 PublicationAs well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified. An additional form starting at Ala-168 has also been identified.

生物活性

≥300 U/mg protein

种属

人(Human)

预测分子量

42 kDa

CAS编号和信息

9025-26-7

酶学委员会编号

EC 3.4.23.5

分子类型

酶

产品线

生物产品

储存与运输

物理形态

冻干(Lyophilized)

储存缓冲液

Lyophilized from 2 mM Na phosphate, pH 6.5

浓度

≥300 U/mg protein；冻干前浓度：见COA

储存条件

-20°C储存,避免反复冻融

运输条件

超低温运输

稳定性与储存

长期储存-20℃（大于1 年）；复溶后建议分装，避免反复冻融。

单位定义

One unit is defined as the amount of enzyme that digests hemoglobin-releasing peptides, which are soluble in 10% TCA. The reaction is measured by an increase in A280 of 1.0 per 60 minutes at 37 °C.

高级数据

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到2个结果

批号(Lot Number)	证书类型	货号
ZJ26F0332642	分析证书	np001110
ZJ26F0332643	分析证书	np001110

技术文档和文章

np001110_cathepsin d from human liver.pdf

组织蛋白酶家族分类与疾病机制：Cathepsin B、D、K、L、S、G 的活性调控和研究应用

目录：技术文章

探索主题:

骨吸收抗原呈递组织蛋白酶炎症小体 Cathepsin Cathepsin B Cathepsin D Cathepsin K Cathepsin L Cathepsin S Cathepsin G CTSB CTSD CTSK CTSL CTSS CTSG 溶酶体蛋白酶组织蛋白酶抑制剂蛋白酶活性检测肿瘤侵袭

Classification and Disease Mechanisms of the Cathepsin Family: Activity Regulation and Research Applications of Cathepsin B, D, K, L, S, and G

目录：技术文章

探索主题:

antigen presentation Bone resorption inflammasome Cathepsin Cathepsin B Cathepsin D Cathepsin K Cathepsin L Cathepsin S Cathepsin G CTSB CTSD CTSK CTSL CTSS CTSG Lysosomal protease Cathepsin inhibitor Protease activity assay Tumor invasion

内肽酶与外肽酶的功能差异及其在疾病机制研究中的应用

目录：技术文章

探索主题:

蛋白质降解 Endopeptidase 氨基肽酶外肽酶 exopeptidase 内肽酶肽段加工羧肽酶二肽基肽酶

Functional Differences Between Endopeptidases and Exopeptidases and Their Applications in Disease Mechanism Research

目录：技术文章

探索主题:

Protein degradation Endopeptidase aminopeptidase exopeptidase Peptide Processing carboxypeptidase dipeptidyl peptidase

溶液计算器