Immobilized Recombinant Human EGFR Isoform vIII Protein (rp176275) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 19.11 ng/mL. Immobilized Recombinant Human EGFR Isoform vIII Protein (rp176275) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 22.53 ng/mL.
Protein Function: As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
规格
产品名称
Recombinant Human EGFR Isoform vIII Protein
别名
重组人EGFR Isoform vIII蛋白 | 重组人类 EGFR 异构体 vIII 蛋白
英文别名
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog | cell growth inhibiting protein 40 | cell proliferation-inducing protein 61 | EC 2.7.10 | EC 2.7.10.1 | EGF R | EGFR | epidermal growth factor receptor (avian erythroblastic leukemia viral (v
Immobilized Recombinant Human EGFR Isoform vIII Protein (rp176275) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 19.11 ng/mL. Immobilized Recombinant Human EGFR Isoform vIII Protein (rp176275) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 22.53 ng/mL.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human EGFR Isoform vIII Protein (rp176275) - ELISA Immobilized Recombinant Human EGFR Isoform vIII Protein (rp176275) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 19.11 ng/mL.
Recombinant Human EGFR Isoform vIII Protein (rp176275) - ELISA Immobilized Recombinant Human EGFR Isoform vIII Protein (rp176275) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 22.53 ng/mL.
Recombinant Human EGFR Isoform vIII Protein (rp176275) - SDS-PAGE 3 μg/lane of Recombinant Human EGFR Isoform vIII Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 56.2-67.2 kDa under reducing conditions.