重组人源化III型胶原蛋白

CAS: 9007-34-5 货号: rp335221 EC号: 232-697-4
有货
级别和纯度: 无动物源 ? 无动物源(Animal Free)—— 不含动物源成分生产,降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体(Carrier Free)—— 不含添加的载体蛋白/稳定剂。当载体(如 BSA)会干扰偶联或敏感检测时使用。 重组 ? 重组(Recombinant)—— 通过重组表达生产,序列确定、批次稳定。适用于来源明确、无动物源的可重现蛋白。 ≥90%(SDS-PAGE) expressed in Nicotiana benthamiana
Accession #
P02461
表达系统
Nicotiana benthamiana
★
规格
库存
价格
数量
1g
rp335221-1g
现货 Stock Image
¥699.90
5g
rp335221-5g
现货 Stock Image
¥1,699.90
10g
rp335221-10g
现货 Stock Image
¥2,699.90
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为什么选择此级别

无动物源,无载体,重组 级 提供 ≥90%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 7 篇同行评审文献引用。

概述

通过植物表达平台经纯化平台,改善了传统胶原蛋白同源性低、批次差异大、存在动物源污染风险的特点。 其与人源胶原氨基酸同源性可达100%, 结构与人体胶原蛋白高度相似,相比传统胶原蛋白提升约1.3倍,低免疫原性;批间一致性提升10倍以上。 同时,该成分的刺激性大幅降低。并能抑制自由基氧化损伤,具有促进细胞增值迁移、提升透明质酸与丝聚蛋白表达、增强皮肤屏障修护及抗皱紧致的作用。 

本品一般为白色或类白色泡沫状/海绵状疏松冻干物。分子呈松散螺旋结构,复溶后形成的溶液或凝胶具有较好的延展性与柔韧性,并表现出良好的保水能力及乳化稳定性。

溶解特性:在中性低盐条件下可溶,在低pH条件下溶解更迅速、完全。

推荐用途:用于高端医疗器械(如创面敷料、填充剂)、功能性护肤品(修复、抗衰)和宠物用。

Through a plant expression platform and purification process, it overcomes the limitations of traditional collagen, such as low homology, high batch-to-batch variation, and the risk of animal-derived contamination. It achieves up to 100% amino acid homology with human collagen and exhibits a structure highly similar to that of human collagen, representing an approximately 1.3-fold improvement over traditional collagen, with low immunogenicity. Batch-to-batch consistency is enhanced by more than 10 times. Meanwhile, the irritancy of this ingredient is significantly reduced. It also inhibits free radical oxidative damage, promotes cell proliferation and migration, enhances the expression of hyaluronic acid and filaggrin, and improves skin barrier repair as well as anti-wrinkle and firming effects. 

This product is typically a white or off-white foamy/spongy loose lyophilizate. The molecule adopts a loose helical structure; upon reconstitution, the resulting solution or gel exhibits good spreadability and flexibility, along with excellent water retention capacity and emulsion stability. 

Solubility characteristics: soluble under neutral low-salt conditions, and dissolves more rapidly and completely at low pH.

Recommended applications: High-end medical devices (e.g., wound dressings, fillers), functional skin care products (repairing, anti-aging), and pet products.

规格

产品名称
重组人源化III型胶原蛋白
别名
重组人Pro-Collagen III alpha 1/COL3A1蛋白 | 重组人III型胶原蛋白
英文别名
alpha1 (III) collagen | alpha-1 type III collagen | COL3A1 | Collagen 3 | collagen alpha-1(III) chain | Collagen III alpha 1 | collagen, fetal | collagen type III alpha 1 | Collagen-3 | collagenIII | Collagen-III | EDS4A | EDSVASC | Ehlers-Danlos syndro.
规格或纯度
无动物源,无载体,重组,≥90%(SDS-PAGE),expressed in Nicotiana benthamiana
生化机理
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. Post-translational: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
表达系统
Nicotiana benthamiana
种属
人(Human)
无载体
Yes
无动物源
Yes
来源
重组表达
SDS-PAGE
15-35 kDa
CAS编号和信息
9007-34-5
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from low-sodium acetate buffer, pH 5.5.
浓度
expressed in Nicotiana benthamiana
复溶
Reconstitute in sterile water or buffer.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃(12个月);复溶后建议分装,避免反复冻融;避光;密封。

技术文档

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高级数据

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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ26F0737464 分析证书 rp335221
ZJ26F0737466 分析证书 rp335221
ZJ26F0737465 分析证书 rp335221
技术文档和文章
α-硫辛酸的皮肤抗老机制:ALA/DHLA 氧化还原循环、抗氧化网络与胶原 AGEs 形成调控
The Skin Anti-Aging Mechanisms of α-Lipoic Acid: ALA/DHLA Redox Cycling, the Antioxidant Network, and Regulation of Collagen AGE Formation
肌肽与脱羧基肌肽的皮肤抗衰老机制:活性羰基捕获、氧化应激缓冲与胶原糖化交联抑制
Skin Anti-Aging Mechanisms of Carnosine and Decarboxy Carnosine: Active Carbonyl Scavenging, Oxidative-Stress Buffering, and Inhibition of Collagen Glycation Cross-Linking
胶原蛋白肽如何作用于皮肤?从表面水合、经皮递送到成纤维细胞与胶原稳态
How Do Collagen Peptides Act on the Skin? From Surface Hydration and Percutaneous Delivery to Fibroblasts and Collagen Homeostasis
卤虫提取物的抗光老化潜力:紫外线损伤级联反应、HSP70相关应激保护与GP4G代谢线索
Anti-Photoaging Potential of Artemia Extract: UV-Induced Damage Cascades, HSP70-Related Stress Protection, and GP4G Metabolic Insights
纤连蛋白的结构与功能:细胞黏附、皮肤创伤修复与外用应用
Structure and Functions of Fibronectin: Cell Adhesion, Cutaneous Wound Repair, and Topical Applications
棕榈酰五肽-4如何作用于皮肤:从KTTKS序列、皮肤递送到胶原基质响应
How Palmitoyl Pentapeptide-4 Acts on the Skin: From the KTTKS Sequence and Skin Delivery to Collagen Matrix Responses
环化如何改变多肽行为:以Cyclopeptide-5为例解析构象预组织、皮肤递送与整合素结合
How Cyclization Changes Peptide Behavior: Conformational Preorganization, Skin Delivery, and Integrin Binding, Using Cyclopeptide-5 as an Example
胶原三肽如何作用于皮肤:角质层递送、基质保护与胶原稳态调节
How Does Collagen Tripeptide Act on the Skin: Stratum Corneum Delivery, Matrix Protection, and Regulation of Collagen Homeostasis
胶原蛋白的功能由什么决定:从三股螺旋形成到层级组装、交联成熟与动态重塑
What Determines Collagen Function: From Triple-Helix Formation to Hierarchical Assembly, Crosslink Maturation, and Dynamic Remodeling
PDRN参与皮肤修复的机制:A2A受体相关信号、核苷酸补救与细胞外基质重塑
Mechanisms by Which PDRN Participates in Skin Repair: A2A Receptor-Related Signaling, Nucleotide Salvage, and Extracellular Matrix Remodeling
“植物胶原蛋白”是什么:原料类型、结构差异、生产方式与护肤作用辨析
What Is “Plant Collagen”? Distinguishing Ingredient Types, Structural Differences, Production Methods, and Skincare Effects
棕榈酰三肽-1与棕榈酰五肽-4的组合逻辑:皮肤递送、基质信号与胶原稳态调节
The Combination Logic of Palmitoyl Tripeptide-1 and Palmitoyl Pentapeptide-4: Skin Delivery, Matrix Signaling, and Regulation of Collagen Homeostasis
动物源胶原蛋白与重组胶原蛋白在护肤中的差异:序列与结构、安全性、皮肤作用及证据评价
Differences Between Animal-Derived Collagen and Recombinant Collagen in Skincare: Sequence and Structure, Safety, Skin Effects, and Evidence Evaluation
此产品的引用文献
溶液计算器