计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
SIRT5 Mouse mAb
有货
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Mouse anti Human SIRT5 Antibody, Monoclonal (OTI2F1), could be used for WB, IHC, IF/ICC, Flow Cytometry and so on.
规格
产品名称
SIRT5 Mouse mAb
别名
沉默调节蛋白5(SIRT5)单克隆抗体
英文别名
EC 2.3.1.- | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | NAD dependent deacetylase sirtuin 5antibody | NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial antibody | NAD dependent protein deacylase sirtuin 5 mitochond
规格或纯度
见COA
生化机理
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
宿主种属
小鼠(Mouse)
特异性
SIRT5
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
Recombinant full length protein of human SIRT5 produced in HEK293.
阳性对照
WB: HEK293T transfected with pCMV6-ENTRY SIRT5 cDNA for 48 hrs, HepG2, HeLa, A549, COS7, PC12, MCF7 lysates. IHC: Human Kidney tissue. IF/ICC: COS7 cells transiently transfected with pCMV6-ENTRY SIRT5. Flow Cytometry: HEK293T cells transfected with pCMV6-
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
亚型
Rabbit IgG
轻链亚型
kappa
纯化方法
Protein G purified
浓度
见COA
分子类型
抗体
储存与运输
物理外观
Liquid
储存缓冲液
10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3
防腐剂
0.02% Sodium azide
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。
应用
应用名称
稀释比例
WB
1/500-1/2000
IF/ICC
1:100
Flow Cytometry
1/100
IHC
1/150
技术文档
高级数据
关联靶点（人）
SIRT5
Tchem
NAD 依赖性蛋白去酰化酶 sirtuin-5，线粒体(NAD-dependent protein deacylase sirtuin-5, mitochondrial)
(0 活性数据)
SIRT5
Tchem
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(1056 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
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