货号 (SKU)

包装规格

是否现货

价格

数量

Ab169274-100μg

100μg

期货

Ab169274-1mg

1mg

现货

Ab169274-5mg

5mg

现货

Ab169274-10mg

10mg

期货

基本信息

产品名称	Emapalumab (anti-IFNγ), 伽马干扰素抑制剂
别名	依帕伐单抗 \| Emapalumab (anti-IFNγ) \| 埃马帕鲁单抗（抗 IFNγ）
英文别名	Recombinant Emapalumab Antibody \| NI-0501 \| Gamifant \| Anti-IFNg Reference Antibody (emapalumab) \| AF 1 antibody \| AF-1 antibody \| AF1 antibody \| IFGR 2 antibody \| IFGR2 antibody \| IFN gamma Receptor beta antibody \| IFN-gamma receptor 2 antibody \| IFN-gam
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	IFNG
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	伽马干扰素抑制剂

AI解读

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	lambda
SDS-PAGE	28.2 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 176.0 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1709815-23-5
分子类型	抗体

图片

ELISA: Emapalumab (anti-IFNγ) (Ab169274)

Emapalumab (anti-IFNγ) (Ab169274) - ELISA
Immobilized Recombinant Human IFN-gamma Protein (rp156182) at 1 μg/mL can bind Emapalumab (anti-IFNγ) (Ab169274) with the EC50 of 25.95 ng/mL.

SEC: Emapalumab (anti-IFNγ) (Ab169274)

Emapalumab (anti-IFNγ) (Ab169274) - SEC
The purity of Emapalumab (anti-IFNγ) (Ab169274) is more than 95% verified by HPLC.

关联靶点（人）

IFNG Tclin 干扰素γ(Interferon gamma) (0 活性数据)

点击查看靶蛋白信息： IFNG

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到2个结果

批号(Lot Number)	证书类型	日期	货号
ZJ23F0800897	分析证书	23-08-25	Ab169274
ZJ23F0800896	分析证书	23-08-25	Ab169274

可替换产品

参考文献

1. Pachlopnik Schmid J, Ho CH, Chrétien F, Lefebvre JM, Pivert G, Kosco-Vilbois M, Ferlin W, Geissmann F, Fischer A, de Saint Basile G. (2009) Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice.. EMBO Mol Med, 1 (2): (112-24). [PMID:20049711] [10.1021/op500134e]
2. Grzesiek, S S and 5 more authors.. (1992) 1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma.. Biochemistry, (8): [PMID:1525157]
3. Ealick, S E SE and 6 more authors.. (1991) Three-dimensional structure of recombinant human interferon-gamma.. Science (New York, N.Y.), (3): [PMID:1902591]
4. Yamamoto, S S, Hase, S S, Yamauchi, H H, Tanimoto, T T and Ikenaka, T T.. (1989) Studies on the sugar chains of interferon-gamma from human peripheral-blood lymphocytes.. Journal of biochemistry, [PMID:2504704]
5. Nishi, T T and 9 more authors.. (1985) Cloning and expression of a novel variant of human interferon-gamma cDNA.. Journal of biochemistry, [PMID:2860101]
6. Pan, Y C YC, Stern, A S AS, Familletti, P C PC, Khan, F R FR and Chizzonite, R R.. (1987) Structural characterization of human interferon gamma. Heterogeneity of the carboxyl terminus.. European journal of biochemistry, (1): [PMID:3109913]
7. Gray, P W PW and 11 more authors.. (1982) Expression of human immune interferon cDNA in E. coli and monkey cells.. Nature, (11): [PMID:6173769]
8. Devos, R R and 5 more authors.. (1982) Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.. Nucleic acids research, (24): [PMID:6176945]
9. Gray, P W PW and Goeddel, D V DV.. (1982) Structure of the human immune interferon gene.. Nature, (26): [PMID:6180322]
10. Taya, Y Y and 5 more authors.. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene.. The EMBO journal, [PMID:6329718]
11. Rinderknecht, E E, O'Connor, B H BH and Rodriguez, H H.. (1984) Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation.. The Journal of biological chemistry, (10): [PMID:6427223]
12. Walter, M R MR and 6 more authors.. (1995) Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.. Nature, (20): [PMID:7617032]
13. Hisamatsu, H H and 10 more authors.. (1996) Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.. The Journal of experimental medicine, (1): [PMID:8666937]
14. Lee, S M; Suen, Y; Qian, J; Knoppel, E and Cairo, M S.. (1998) The regulation and biological activity of interleukin 12.. Leukemia & lymphoma, [PMID:9643557]
15. Landar, A A and 7 more authors.. (2000) Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma.. Journal of molecular biology, (26): [PMID:10860730]
16. Thiel, D J DJ and 8 more authors.. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.. Structure (London, England : 1993), (15): [PMID:10986460]
17. Dufour, Carlo C and 16 more authors.. (2004) Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population.. British journal of haematology, [PMID:15327519]
18. El Bougrini, J J, Pampin, M M and Chelbi-Alix, M K MK.. (2006) Arsenic enhances the apoptosis induced by interferon gamma: key role of IRF-1.. Cellular and molecular biology (Noisy-le-Grand, France), (15): [PMID:16914093]
19. Ito, R R and 12 more authors.. (2006) Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice.. Clinical and experimental immunology, [PMID:17034586]
20. Kaplon, Hélène and Reichert, Janice M.. Antibodies to watch in 2018.. mAbs, [PMID:29300693]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Emapalumab (anti-IFNγ), 伽马干扰素抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

AI解读

产品属性

图片

关联靶点（人）

作用机制

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

相关技术文章

Emapalumab (anti-IFNγ), 伽马干扰素抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

AI解读

产品属性

图片

关联靶点（人）

作用机制

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

相关产品

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

相关技术文章