弹性蛋白酶 来源于人中性粒细胞

CAS: 9004-06-2 货号: np001098 EC号: 232-670-7
有货
级别和纯度: 生物活性 ? 生物活性级(Bioactive)—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 高性能 ? 高性能级 —— 纯度和性能特性经过优化。适用于普通等级无法满足的灵敏分析。 EnzymoPure™ ? EnzymoPure™ —— 阿拉丁的高质量酶解决方案系列。当酶纯度和明确活性决定检测或工艺性能时使用。 ≥95%(SDS-PAGE) Pre-lyophilization Protein Concentration
Accession #
P08246
生物活性
20-22 U/mg protein
★
规格
库存
价格
数量
25μg
np001098-25μg
现货 Stock Image
¥2,999.90
100μg
np001098-100μg
现货 Stock Image
¥9,999.90
请输入您要添加的产品数量
🧪

为什么选择此级别

ActiBioPure™,EnzymoPure™,生物活性,高性能 级 提供 ≥95%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。

🌡

储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 13 篇同行评审文献引用。

概述


This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.
Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

规格

产品名称
弹性蛋白酶 来源于人中性粒细胞
别名
人中性粒细胞弹性蛋白酶 | 弹性蛋白酶 | 人中性粒细胞
英文别名
Bone marrow serine protease | EC 3.4.21 | EC 3.4.21.37 | ELA2 | granulocyte-derived elastase | ELANE | elastase 2 | neutrophil | elastase | neutrophil expressed | Elastase-2 | GE | HNE | Human leukocyte elastase | Leukocyte Elastase | Medullasin | NE | Ne
规格或纯度
ActiBioPure™, 生物活性, 高性能, EnzymoPure™, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration
生化机理
Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae. Catalytic activity: Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
生物活性
20-22 U/mg protein
种属
人(Human)
Accession #
来源
天然
预测分子量
29.5 kDa
CAS编号和信息
9004-06-2
酶学委员会编号
3.4.21.37
分子类型
酶
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from De-ionized water.
浓度
Pre-lyophilization Protein Concentration
复溶
After centrifugation, we suggest addition of 52.1 uL of 50 mM Na Acetate, pH 5.5, with 150 mMNaCl to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃(大于1年);复溶后建议分装,避免反复冻融。
单位定义
One unit is defined as the amount of enzyme which hydrolyzes one umole of Meo-suc-ala-ala-pro-val-pNA per minute at 25oC in 100 mMTris-HCl, pH 7.5, with 500 mMNaCl.

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到4个结果

批号(Lot Number) 证书类型 货号
ZJ26F0838516 分析证书 np001098
ZJ26F0838517 分析证书 np001098
ZJ26F0333379 分析证书 np001098
ZJ25F0825770 分析证书 np001098
技术文档和文章
科研常用蛋白酶的基础介绍与典型应用
Commonly Used Proteases in Research: Fundamentals and Representative Applications
蛋白酶在呼吸系统与血管系统疾病中的作用与机制
Roles and Mechanisms of Proteases in Respiratory and Vascular Diseases
内肽酶与外肽酶的功能差异及其在疾病机制研究中的应用
Functional Differences Between Endopeptidases and Exopeptidases and Their Applications in Disease Mechanism Research
丝氨酸内切蛋白酶的催化机制、分类特征与实验应用
Catalytic Mechanisms, Classification Characteristics, and Experimental Applications of Serine Endopeptidases
中性粒细胞效应蛋白:抗微生物效应与炎症调控
Neutrophil Effector Proteins: Antimicrobial Effects and Inflammatory Regulation
中性粒细胞与肿瘤:双重作用与靶向策略
Neutrophils and Cancer: Dual Roles and Targeting Strategies
此产品的引用文献
引用文献
1. Jin Zhang, Chunsheng Xiao, Xi Zhang, Yandai Lin, Huanghao Yang, Yu Shrike Zhang, Jianxun Ding.  (2021)  An oxidative stress-responsive electrospun polyester membrane capable of releasing anti-bacterial and anti-inflammatory agents for postoperative anti-adhesion.  JOURNAL OF CONTROLLED RELEASE,  [PMID:33895199] [10.1016/j.jconrel.2021.04.017]
2. Zhang Huaiyu, Zhang Jiayu, Liu Yilun, Jiang Yang, Li Zhongmin.  (2021)  Molecular Targeted Agent and Immune Checkpoint Inhibitor Co-Loaded Thermosensitive Hydrogel for Synergistic Therapy of Rectal Cancer.  Frontiers in Pharmacology,  [PMID:33935796] [10.3389/fphar.2021.671611]
3. Qiu Renna, Li Jian, Sun Denghua, Li Hongjun, Qian Feng, Wang Lizhe.  (2019)  20(S)-Ginsenoside Rg3-loaded electrospun membranes to prevent postoperative peritoneal adhesion.  BIOMEDICAL MICRODEVICES,  21  (4): (1-11).  [PMID:31414228] [10.1007/s10544-019-0425-6]
4. Wenjing Zhang, Weiguo Xu, Cong Ning, Mingqiang Li, Guoqing Zhao, Weiqian Jiang, Jianxun Ding, Xuesi Chen.  (2018)  Long-acting hydrogel/microsphere composite sequentially releases dexmedetomidine and bupivacaine for prolonged synergistic analgesia.  BIOMATERIALS,  [PMID:30099261] [10.1016/j.biomaterials.2018.07.051]
5. Gao Zhen, Wang Jing, Jing Jing, Dan Xu, Li Zheng, Fengsen Li.  (2018)  Effects of Modified Zhisou Powder on Airway Mucus Production in Chronic Obstructive Pulmonary Disease Model Rats with Cold-Dryness Syndrome.  Evidence-based Complementary and Alternative Medicine,  [PMID:30105060] [10.1155/2018/7297141]
6. Wenjing Zhang, Cong Ning, Weiguo Xu, Hanze Hu, Mingqiang Li, Guoqing Zhao, Jianxun Ding, Xuesi Chen.  (2018)  Precision-guided long-acting analgesia by Gel-immobilized bupivacaine-loaded microsphere.  Theranostics,  [PMID:29930733] [10.7150/thno.25276]
7. Jiannan Li, Xiangru Feng, Jian Shi, Tongjun Liu, Jianxun Ding.  (2018)  Porous Polylactide Film Plus Atorvastatin-Loaded Thermogel as an Efficient Device for Peritoneal Adhesion Prevention.  ACS Omega,  [PMID:30023849] [10.1021/acsomega.8b00090]
8. Jiannan Li, Weiguo Xu, Jinjin Chen, Di Li, Kai Zhang, Tongjun Liu, Jianxun Ding, Xuesi Chen.  (2017)  Highly Bioadhesive Polymer Membrane Continuously Releases Cytostatic and Anti-Inflammatory Drugs for Peritoneal Adhesion Prevention.  ACS Biomaterials Science & Engineering,  [PMID:33445273] [10.1021/acsbiomaterials.7b00605]
9. Xuezhou Li, Jianxun Ding, Zhengzheng Zhang, Modi Yang, Jiakuo Yu, Jincheng Wang, Fei Chang, Xuesi Chen.  (2016)  Kartogenin-Incorporated Thermogel Supports Stem Cells for Significant Cartilage Regeneration.  ACS Applied Materials & Interfaces,  [PMID:26844837] [10.1021/acsami.5b12212]
10. Song Zhiming, Shi Bo, Ding Jianxun, Zhuang Xiuli, Zhang Xiaonan, Fu Changfeng, Chen Xuesi.  (2015)  A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics.  Science China-Chemistry,  58  (7): (1159-1168).  [10.1007/s11426-015-5425-7]
11. Song Zhi-ming, Shi Bo, Ding Jian-xun, Zhuang Xiu-li, Zhang Xiao-nan, Fu Chang-feng, Chen Xue-si.  (2015)  Prevention of postoperative tendon adhesion by biodegradable electrospun membrane of poly(lactide-co-glycolide).  CHINESE JOURNAL OF POLYMER SCIENCE,  33  (4): (587-596).  [10.1007/s10118-015-1611-5]
12. Le-Yu Huang, Huiling Wang, Yue-Yang Zhang, Shi-Yu Liu.  (2025)  An acylaminoacyl-peptide hydrolase-activated fluorescent probe for ultrasensitive detection of pesticide residue.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  [PMID:40188572] [10.1016/j.saa.2025.126152]
13. Yue-Yang Zhang, Zi-Xin Chen, Gang Nie, Huiling Wang, Qiaolin Li, Shi-Yu Liu.  (2026)  Aspirin-based esters for carboxylesterase 2-targeted bioimaging and drug delivery.  SENSORS AND ACTUATORS B-CHEMICAL,  [10.1016/j.snb.2026.140793]
溶液计算器