Recombinant Human ErbB3/HER3 Protein

Name: Recombinant Human ErbB3/HER3 Protein
SKU: rp170123
Availability: InStock

货号: rp170123

COA

有货

级别和纯度: 无动物源 ? 无载体 ? 生物活性 ? ActiBioPure™ ? His标签 ? PBS Only ? ≥90%(SDS-PAGE)

Accession #

P21860

蛋白标签

C-His

表达系统

HEK293

内毒素水平

<1.0 EU/μg

生物活性

Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.

规格

库存

价格

数量

10μg

rp170123-10μg

现货

¥379.90

50μg

rp170123-50μg

现货

¥1,139.90

100μg

rp170123-100μg

现货

¥1,999.90

1mg

rp170123-1mg

期货

¥12,399.90

请输入您要添加的产品数量

大包装 / 定制

♡ 收藏夹 ⇅ 比较 ⎙ 打印页面

Skip to the end of the images gallery

Skip to the beginning of the images gallery

概述规格储存与运输图片技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章溶液计算器

🧪

为什么选择此级别

ActiBioPure™,His标签,PBS Only,无动物源,无载体,生物活性级提供 ≥90%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

🌡

储存与运输

-20°C储存,避免反复冻融。超低温运输。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

概述

Protein Function:：
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

规格

产品名称

Recombinant Human ErbB3/HER3 Protein

别名

重组人ErbB3/HER3蛋白 | 重组人 ErbB3/HER3 蛋白

英文别名

规格或纯度

无动物源,无载体,生物活性,ActiBioPure™,His标签,PBS Only,≥90%(SDS-PAGE)

生物活性

表达系统

HEK293

种属

人(Human)

氨基酸

1-643 aa

序列

MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTHHHHHH

蛋白标签

C-His

无载体

Yes

无动物源

Yes

来源

重组表达

预测分子量

69.5 kDa

SDS-PAGE

81.5-101.9 kDa, under reducing conditions; 74.3-99.3 kDa, under non-reducing conditions

分子类型

蛋白质

产品线

biological_products

储存与运输

物理形态

冻干(Lyophilized)

储存缓冲液

Lyophilized from PBS, pH 7.4

复溶

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

储存条件

-20°C储存,避免反复冻融

运输条件

超低温运输

稳定性与储存

在 -20°C 下可保存 1 年。避免冷冻/解冻循环。

图片

ELISA: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA
Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL.

ELISA: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA
Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL.

ELISA: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA
Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL.

ELISA: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA
Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.

SDS-PAGE: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - SDS-PAGE
3 μg/lane of Recombinant Human ErbB3/HER3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 81.5-101.9 kDa under reducing conditions and 74.3-99.3 kDa under non-reducing conditions.

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0708304	分析证书	rp170123
ZJ24F0708305	分析证书	rp170123
ZJ24F0708306	分析证书	rp170123

技术文档和文章

阿拉丁®靶点蛋白

目录：技术文章

探索主题:

药物开发信号通路细胞因子靶点蛋白药物靶点受体免疫检查点细胞表面标记物

细胞培养通用指南

目录：实验方案（Protocols）

探索主题:

培养基细胞培养贴壁细胞悬浮细胞生长因子黏附细胞冷冻细胞传代

ErbB家族通路的结构特征、激活逻辑与信号输出

目录：技术文章

探索主题:

EGFR PI3K-AKT ErbB HER2 HER3 HER4 受体酪氨酸激酶 RAS-ERK 二聚化

Structural Features, Activation Logic, and Signaling Output of the ErbB Family Pathway

目录：技术文章

探索主题:

EGFR PI3K-AKT ErbB HER2 HER3 HER4 RAS-ERK Receptor tyrosine kinase Dimerization

Aladdin® Target Proteins

目录：技术文章

探索主题:

Cytokines Drug development Target Proteins Drug Targets Receptors Immune Checkpoints Cell Surface Markers Signaling Pathways

General Guidelines for Cell Culture

目录：实验方案（Protocols）

探索主题:

cell culture Suspension cells Growth factors adherent cells adhesion culture medium cell freezing cell passage

HER3信号网络在肿瘤进展、治疗耐药与靶向干预中的作用

目录：技术文章

探索主题:

抗体偶联药物 EGFR PI3K/AKT HER2 HER3 ERBB3 NRG1 异源二聚化治疗耐药双特异性抗体

Role of the HER3 Signaling Network in Tumor Progression, Therapeutic Resistance, and Targeted Intervention

目录：技术文章

探索主题:

EGFR PI3K/AKT HER2 HER3 ERBB3 NRG1 heterodimerization therapeutic resistance bispecific antibody antibody-drug conjugate

受体酪氨酸激酶异常信号在肿瘤发生、精准分型与靶向治疗中的作用

目录：技术文章

探索主题:

靶向治疗 EGFR PI3K/AKT ALK HER2 受体酪氨酸激酶 FGFR MAPK 耐药机制 RTK RET MET 基因融合精准分型

Role of Aberrant Receptor Tyrosine Kinase Signaling in Tumorigenesis, Precision Classification, and Targeted Therapy

目录：技术文章

探索主题:

Targeted therapy EGFR PI3K/AKT ALK HER2 Receptor tyrosine kinase FGFR MAPK Resistance Mechanism RTK RET MET gene fusion precision classification

ADC热门抗肿瘤靶标：信号机制与靶向治疗进展

目录：技术文章

探索主题:

ADC HER2 HER3 TROP2 Nectin-4 FRα c-Met B7-H3 CLDN18.2 DLL3 肿瘤靶标

Leading ADC Targets in Oncology: Signaling Mechanisms and Therapeutic Advances

目录：技术文章

探索主题:

ADC HER2 HER3 TROP2 Nectin-4 FRα c-Met B7-H3 CLDN18.2 DLL3 tumor targets

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

需要帮助选择级别？

我们的级别选择指南涵盖了目录中所有的变体的纯度、稳定剂状态和应用适用性。

查看 Animal Free 级别指南 → 查看 Carrier Free 级别指南 → 查看 Bioactive 级别指南 → 查看 ActiBioPure™ 级别指南 → 查看 His Tag 级别指南 → 查看 PBS Only 级别指南 →

大包装与定制包装 需要更大包装或定制规格？请联系我们的团队获取专属报价。

Recombinant Human ErbB3/HER3 Protein

储存与运输

质量文档

文献证明

概述

规格

技术文档

📋 安全数据表 (SDS)

✅ 分析证书 (COA)

📊 产品数据表

🔬 规格说明书

高级数据

摩尔浓度计算器

稀释计算器

复溶计算器

需要帮助选择级别？

查看相关“主题”系列