计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
DRP1 Mouse mAb
有货
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Mouse anti Human DRP1 Antibody, Monoclonal (OTI3F3), could be used for WB, IHC, IF/ICC and so on.
规格
产品名称
DRP1 Mouse mAb
别名
动力相关蛋白1多克隆抗体 | 动力相关蛋白1抗体 | 动力相关蛋白1单克隆抗体 | DRP1抗体 | DRP1单克隆抗体 | DNM1L抗体 | DNM1L单克隆抗体
英文别名
DLP1 antibody | dnm1l antibody | DNM1L_HUMAN antibody | Dnm1p/Vps1p-like protein antibody | dnml1 antibody | DRP1 antibody | DVLP antibody | Dymple antibody | Dynamin 1 like antibody | Dynamin family member proline-rich carboxyl-terminal domain less antib
规格或纯度
见COA
生化机理
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.
Post-translational: Phosphorylation/dephosphorylation events on two sites near the GED domain regulate mitochondrial fission. Phosphorylation on Ser-637 inhibits mitochondrial fissin probably through preventing intramolecular interaction. Dephosphorylated on this site by PPP3CA which promotes mitochondrial fission. Phosphorylation on Ser-616 also promotes mitochondrial fission. Sumoylated on various lysine residues within the B domain. Desumoylated by SENP5 during G2/M transition of mitosis. Appears to be linked to its catalytic activity.
S-nitrosylation increases DNM1L dimerization, mitochondrial fission and causes neuronal damage. Ubiquitination by MARCH5 affects mitochondrial morphology.
宿主种属
小鼠(Mouse)
特异性
DRP1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
Recombinant protein of human DNM1L (AA 1-736).
阳性对照
WB: HepG2, HeLa, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF7 lysates. IHC: Human kidney, ovary adenocarcinoma, bladder, bladder carcinoma tissues. IF/ICC: COS7 cells.
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
亚型
Rabbit IgG
纯化方法
Protein A/G purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
物理外观
Liquid
储存缓冲液
10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3
防腐剂
0.02% Sodium azide
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。
应用
应用名称
稀释比例
IF/ICC
1:100
WB
1/4000
IHC
1/150
技术文档
高级数据
关联靶点（人）
DNM1L
Tchem
动力蛋白-1类蛋白(Dynamin-1-like protein)
(0 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
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产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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