G2617008计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 242 篇同行评审文献引用。
概述
An antiinflammatory glucocorticoid
Information
Dexamethasone (MK-125) Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effe
In vitro
Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG.
In vivo
Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
别名
地塞米松（MK-125）
英文别名
NSC 34521, Hexadecadrol, Prednisolone F | (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,13,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3(9H,10H,14H)-one
规格或纯度
10mM in DMSO
英文名称
Dexamethasone (MK-125)
生化机理
地塞米松（MK-125，NSC 34521，Hexadecadrol，Prednisolone F）是一种强效合成糖皮质激素类固醇药物，也是一种白细胞介素受体调节剂，具有抗炎和免疫抑制作用。地塞米松可诱导自噬和有丝分裂。地塞米松在 COVID-19 的住院病人中进行了测试，发现对危重病人有好处。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
EC号
200-003-9
分子类型
小分子
Isomeric SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
关联CAS
NSC Number
34521
MeSH Entry Terms
Decaject;Decaject L.A.;Decaject-L.A.;Decameth;Decaspray;Dexamethasone;Dexasone;Dexpak;Hexadecadrol;Hexadrol;Maxidex;Methylfluorprednisolone;Millicorten;Oradexon
分子量
392.46
Beilstein号
2066651
Reaxy-Rn
2341697
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2341697&ln=
技术文档
高级数据
产品属性
| ALogP | 1.9 |
|---|
关联靶点（人）
NR3C1
Tclin
糖皮质激素受体(Glucocorticoid receptor)
(0 活性数据)
NR3C2
Tclin
盐皮质激素受体(Mineralocorticoid receptor)
(0 活性数据)
NR1I2
Tchem
核受体亚家族 1 第 I 组成员 2(Nuclear receptor subfamily 1 group I member 2)
(0 活性数据)
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 100 mg/mL (160.1 mM);
熔点
262-264°C
安全和危险性（GHS）
WGK Germany
2
RTECS
TU3980000
质检证书（CoA,COO,BSE/TSE 和分析图谱)
技术文档和文章
Glucocorticoids (GCs) and the Glucocorticoid Receptor (GR): Mechanisms, Classification Frameworks, and the Latest Advances (with a Product Selection Table)
目录： 技术文章
糖皮质激素的科学综述与应用要点
目录： 技术文章
How to Map the NF-κB Pathway and Choose Inhibitors: Bringing Inflammatory Transcriptional Output into a “Controllable Range” (Tables A–F)
目录： 技术文章
Mechanisms and Experimental Applications of β-GP, Ascorbic Acid, and Dexamethasone in Osteogenic Induction Systems
目录： 技术文章
糖尿病动物模型建立与评价方法
目录： 技术文章
Inflammatory Signaling Pathway Research Guide: Danger Signal Recognition, Core Signaling Modules, Detection Readouts, and Representative Research Reagents
目录： 技术文章
Applications of Endocrinology/Hormones in Metabolic Regulation, Reproductive Function, and Disease Research
目录： 技术文章
Gentiana Root Extract and Gentiopicroside: Chemical Composition, Antioxidant and Inflammation-Modulating Mechanisms, and Their Potential Effects on Skin Barrier Homeostasis
目录： 技术文章
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）