计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
有货
为什么选择此级别
Moligand™ 级 提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温,干燥。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 62 篇同行评审文献引用。
概述
溶于水，不溶于醚。
规格
别名
丁酸钠盐
英文别名
MFCD00002816 | Sodium butyrate [USP] | NSC 174280 | CCG-266046 | Q305004 | Sodium butyrate, 98% | AKOS015899795 | Butanoic acid, sodium salt | 8RAS91C36W | D08998 | BCP31813 | Butanoicacidsodiumsalt butyratesodium | C4H7NaO2 | Tox21_112550 | A921858 | SCH
规格或纯度
Moligand™, ≥98%
英文名称
Sodium butyrate
生化机理
组蛋白脱乙酰基酶抑制剂。在阿尔茨海默氏病转基因小鼠模型中恢复上下文记忆。显示可诱导胰腺祖细胞形成。当与细胞因子激活素A结合使用时，指导小鼠胚胎干细胞向肝细胞的分化。还增强了转录因子刺激的iPSC生成。
储存条件
室温,干燥
运输条件
常规运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
PubChem SID
EC号
205-857-6
分子类型
小分子
IUPAC Name
sodium;butanoate
INCHI
1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChi Key
MFBOGIVSZKQAPD-UHFFFAOYSA-M
Smiles
CCCC(=O)[O-].[Na+]
Isomeric SMILES
CCCC(=O)[O-].[Na+]
PubChem CID
分子量
110.09
Beilstein号
3629439
Reaxy-Rn
3629439
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 脂质和脂质样分子 |
| 类（Class) | 脂肪酰基 |
| 亚类（Subclass） | 脂肪酸及其共轭物 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 脂肪酸及其共轭物 |
| 其他上位类（Alternative Parents） | 羧酸盐 一元羧酸及其衍生物 羧酸 有机钠盐 有机氧化物 碳氢化合物衍生物 羰基化合物 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 脂肪族非环化合物 - 羰基 - 羧酰胺基 - 羧酸衍生物 - 羧酸盐 - 脂肪酸 - 烃衍生物 - 单羧酸或其衍生物 - 有机碱金属盐 - 有机氧化物 - 有机氧化合物 - 有机盐 - 有机钠盐 - 有机氧化合物 |
| 描述（Description） | 该化合物属于脂肪酸及其衍生物类有机化合物。这类化合物是具有饱和或不饱和脂肪族尾链（含至少4个碳原子）的脂肪族单羧酸。 |
| 外部描述符（External Descriptors） | organic sodium salt |
三维结构
交互式化学结构模型
关联靶点（人）
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
CA1
Tclin
Carbonic anhydrase I
(13240 活性数据)
HDAC8
Tclin
Histone deacetylase 8
(4516 活性数据)
HDAC2
Tclin
Histone deacetylase 2
(3971 活性数据)
HDAC3
Tclin
Histone deacetylase 3
(3654 活性数据)
A498
(42825 活性数据)
ACHN
(49357 活性数据)
BT-20
(503 活性数据)
CAKI-1
(44928 活性数据)
CCRF-CEM
(65223 活性数据)
COLO 205
(50209 活性数据)
DU-145
(51482 活性数据)
HL-60
(67320 活性数据)
HT-29
(80576 活性数据)
K562
(73714 活性数据)
KM12
(47707 活性数据)
M14
(47487 活性数据)
MCF7
(126967 活性数据)
MOLT-4
(49676 活性数据)
OVCAR-3
(48710 活性数据)
OVCAR-4
(44535 活性数据)
OVCAR-5
(45555 活性数据)
OVCAR-8
(47708 活性数据)
PC-3
(62116 活性数据)
RPMI-8226
(44974 活性数据)
RXF 393
(41971 活性数据)
SF-295
(48000 活性数据)
SK-MEL-2
(46422 活性数据)
SK-MEL-28
(48833 活性数据)
SK-MEL-5
(47095 活性数据)
SK-OV-3
(52876 活性数据)
SN12C
(47755 活性数据)
SNB-19
(46794 活性数据)
TK-10
(45540 活性数据)
U-251
(51189 活性数据)
UACC-257
(46019 活性数据)
UACC-62
(47335 活性数据)
UO-31
(46270 活性数据)
786-0
(47912 活性数据)
A549
(127892 活性数据)
NCI/ADR-RES
(33767 活性数据)
T47D
(39041 活性数据)
EKVX
(44102 活性数据)
NCI-H322M
(45589 活性数据)
HCC 2998
(41480 活性数据)
HCT-116
(91556 活性数据)
HOP-92
(41141 活性数据)
Hs-578T
(29457 活性数据)
NCI-H460
(60772 活性数据)
SF-268
(49410 活性数据)
关联靶点（其它种属）
Coagulation factor III (5 活性数据)
Hdac1
Histone deacetylase 1 (93 活性数据)
HD1
Histone deacetylase (38 活性数据)
Carbonic anhydrase (69 活性数据)
EL4 (235 活性数据)
hda106
Histone deacetylase HD2 (351 活性数据)
Serum (58 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
溶于water, 最高浓度 (mg/mL): 11.01, 最高浓度(mM): 100
密度
0.987
敏感性
易吸潮
熔点
250-253°C
分子量
110.090 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count
0
氢键受体数Hydrogen Bond Acceptor Count
2
可旋转键计数Rotatable Bond Count
2
精确质量Exact Mass
110.034 Da
单同位素质量Monoisotopic Mass
110.034 Da
拓扑极表面积Topological Polar Surface Area
40.100 Ų
重原子数Heavy Atom Count
7
形式电荷Formal Charge
0
复杂度Complexity
53.700
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
2
安全和危险性（GHS）
信号词
警告
危险声明
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
H341: 怀疑引起遗传缺陷
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P271: 仅在室外或通风良好的地方使用。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P281: 根据需要使用个人防护设备。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P501: 将内容物/容器处理到。。。
P203: 使用前，获取、阅读并遵守所有安全说明。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P318: 如果暴露或担心，请就医。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
1
RTECS
ET6400000
个人防护装备
dust mask type N95 (US),Eyeshields,Gloves
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此产品的引用文献
引用文献
| 1. Huijie Duan, Junya Hu, Yang Deng, Junqing Zou, Wangli Ding, Qiang Peng, Rui Duan, Jianguo Sun, Junrong Zhu. (2023) Berberine Mediates the Production of Butyrate to Ameliorate Cerebral Ischemia via the Gut Microbiota in Mice. Nutrients, 16 (1): (9). [PMID:38201839] [10.3390/nu16010009] |
| 2. Sun Penghao, Wang Mengli, Liu Yong-Xin, Li Luqi, Chai Xuejun, Zheng Wei, Chen Shulin, Zhu Xiaoyan, Zhao Shanting. (2023) High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism. Microbiome, 11 (1): (1-20). [PMID:37468922] [10.1186/s40168-023-01606-x] |
| 3. Zhang Ke, Ji Xiawei, Song Zhengyang, Song Wenjing, Huang Qunjia, Yu Tiantian, Shi Dibang, Wang Fangyan, Xue Xiangyang, Guo Junping. (2023) Butyrate inhibits the mitochondrial complex Ι to mediate mitochondria-dependent apoptosis of cervical cancer cells. BMC Complementary Medicine and Therapies, 23 (1): (1-14). [PMID:37370057] [10.1186/s12906-023-04043-3] |
| 4. Shaoyan Zhang, Jinfeng Ning, Qingqing Wang, Wei Wang. (2023) Fluorescence enhancement of flavonoids and its application in ingredient determination for some traditional Chinese medicines by CE-LIF. Analytical Methods, 15 (24): (2964-2970). [PMID:37309583] [10.1039/D3AY00486D] |
| 5. Wenkai Zhang, Li Kong, Zhen Zhong, Lezhen Lin, Jingen Li, Guodong Zheng. (2023) Short chain fatty acids increase fat oxidation and promote browning through β3-adrenergic receptor/AMP-activated protein kinase α signaling pathway in 3T3-L1 adipocytes. Journal of Functional Foods, [10.1016/j.jff.2023.105488] |
| 6. Liu Han, Zhao Jing, Zhang Wenju, Nie Cunxi. (2023) Impacts of sodium butyrate on intestinal mucosal barrier and intestinal microbial community in a weaned piglet model. Frontiers in Microbiology, [PMID:36713180] [10.3389/fmicb.2022.1041885] |
| 7. Jiang Hui, Mao Tangyou, Sun Zhongmei, Shi Lei, Han Xiao, Zhang Yang, Zhang Xiaosi, Wang Jiali, Hu Juncong, Zhang Liming, Li Junxiang, Han Haixiao. (2022) Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut microbiota. Frontiers in Microbiology, [PMID:36578580] [10.3389/fmicb.2022.1001778] |
| 8. Weijun Chen, Shiyang Gao, Kuo Chang, Xiaoyu Zhao, Ben Niu. (2022) Dietary sodium butyrate supplementation improves fish growth, intestinal microbiota composition, and liver health in largemouth bass (Micropterus salmoides) fed high-fat diets. AQUACULTURE, [10.1016/j.aquaculture.2022.739040] |
| 9. Jiaxiu Liu, Wenxiu Zhu, Ningbo Qin, Xiaomeng Ren, Xiaodong Xia. (2022) Propionate and Butyrate Inhibit Biofilm Formation of Salmonella Typhimurium Grown in Laboratory Media and Food Models. Foods, 11 (21): (3493). [PMID:36360105] [10.3390/foods11213493] |
| 10. Xue Tang, Yongjuan Sun, Yingrui Li, Shuhua Ma, Kai Zhang, Ailing Chen, Yipin Lyu, Renqiang Yu. (2022) Sodium butyrate protects against oxidative stress in high-fat-diet-induced obese rats by promoting GSK-3β/Nrf2 signaling pathway and mitochondrial function. JOURNAL OF FOOD BIOCHEMISTRY, 46 (10): (e14334). [PMID:35848364] [10.1111/jfbc.14334] |
| 11. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, [PMID:35392552] [10.3389/fphar.2022.842720] |
| 12. Liang Liping, Liu Le, Zhou Wanyan, Yang Chenghai, Mai Genghui, Li Haolin, Chen Ye. (2022) Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway. CLINICAL SCIENCE, 136 (4): (291-307). [PMID:35194640] [10.1042/CS20210778] |
| 13. Suhang Guo, Yi Peng, Yan Lou, Lijuan Cao, Junqing Liu, Nengming Lin, Sheng Cai, Yu Kang, Su Zeng, Lushan Yu. (2022) Downregulation of the farnesoid X receptor promotes colorectal tumorigenesis by facilitating enterotoxigenic Bacteroides fragilis colonization. PHARMACOLOGICAL RESEARCH, [PMID:35104632] [10.1016/j.phrs.2022.106101] |
| 14. Han Jia, Shaoyan Wang, Yingbiao Xu, Tingyi Wang, Lingyu Zhang, Jinyong Song, Xuehao Zhang, Lin Song, Haidong Jia, Hui Yan. (2021) Systematic investigation on the abnormal surface and interfacial activity of fatty acid ionic liquids. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [10.1016/j.colsurfa.2021.127902] |
| 15. Shanmeiyu Zhang, Yanyan Zhang, Chongchong Wu, Hui Yang, Qiqi Zhang, Fuyi Wang, Jingyi Wang, Ian Gates, Jinben Wang. (2021) A Facile Strategy to Prepare Small Water Clusters via Interacting with Functional Molecules. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (15): (8250). [PMID:34361016] [10.3390/ijms22158250] |
| 16. Wenxiu Zhu, Jingzhu Gao, Hongli Liu, Jiaxiu Liu, Tong Jin, Ningbo Qin, Xiaomeng Ren, Xiaodong xia. (2021) Antibiofilm effect of sodium butyrate against Vibrio parahaemolyticus. FOOD CONTROL, [10.1016/j.foodcont.2021.108422] |
| 17. Guanjing Cai, Gefu Zhu, Mingdian Zhou, Nan Lv, Ruming Wang, Chunxing Li, Junjie Li, Xiaofang Pan. (2021) Syntrophic butyrate-oxidizing methanogenesis promoted by anthraquinone-2-sulfonate and cysteine: Distinct tendencies towards the enrichment of methanogens and syntrophic fatty-acid oxidizing bacteria. BIORESOURCE TECHNOLOGY, [PMID:33838452] [10.1016/j.biortech.2021.125074] |
| 18. Lihui Yang, Xiao Zhao, Manjun Lei, Jie Sun, Lei Yang, Yifeng Shen, Qiangqiang Zhao. (2020) Facile construction of thermo-responsive Pickering emulsion for esterification reaction in phase transfer catalysis system. Molecular Catalysis, [10.1016/j.mcat.2020.111335] |
| 19. Xiaoxuan Yu, Hui Li, Po Hu, Yingjie Qing, Xiangyuan Wang, Mengyuan Zhu, Hongzheng Wang, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Hui Hui. (2020) Natural HDAC-1/8 inhibitor baicalein exerts therapeutic effect in CBF-AML. Clinical and Translational Medicine, 10 (4): (e154). [PMID:32898337] [10.1002/ctm2.154] |
| 20. Baifei Hu, Cheng Ye, Elaine Lai-Han Leung, Lin Zhu, Haiming Hu, Zhigang Zhang, Junping Zheng, Hongtao Liu. (2020) Bletilla striata oligosaccharides improve metabolic syndrome through modulation of gut microbiota and intestinal metabolites in high fat diet-fed mice. PHARMACOLOGICAL RESEARCH, [PMID:32504835] [10.1016/j.phrs.2020.104942] |
| 21. Yuan Yin, Li Bo, Kuang Yanbin, Ni Shuo, Zhuge Aoxiang, Yang Jing, Lv Longxian, Gu Silan, Yan Ren, Li Yating, Wang Kaicen, Yang Liya, Zhu Xueling, Wu Jingjing, Bian Xiaoyuan, Li Lanjuan. (2020) The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells. Cancer Cell International, 20 (1): (1-14). [PMID:32518521] [10.1186/s12935-020-01305-9] |
| 22. Gao Feng, Lv Yi-Wei, Long Jie, Chen Jie-Mei, He Jiu-ming, Ruan Xiong-Zhong, Zhu Hai-bo. (2019) Butyrate Improves the Metabolic Disorder and Gut Microbiome Dysbiosis in Mice Induced by a High-Fat Diet. Frontiers in Pharmacology, [PMID:31607907] [10.3389/fphar.2019.01040] |
| 23. Feng Wenqian, Wu Yancheng, Chen Guangxin, Fu Shoupeng, Li Bai, Huang Bingxu, Wang Dali, Wang Wei, Liu Juxiong. (2018) Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 47 (4): (1617-1629). [PMID:29949795] [10.1159/000490981] |
| 24. Dan-Ting Yin, Yu Fu, Xin-Huai Zhao. (2018) In vitro activities of inulin fermentation products to HCT-116 cells enhanced by the cooperation between exogenous strains and adult faecal microbiota. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, [PMID:29318896] [10.1080/09637486.2017.1418844] |
| 25. Dan-Ting Yin, Xin-Huai Zhao. (2017) Impact of exogenous strains on in vitro fermentation and anti-colon cancer activities of maize resistant starch and xylo-oligosaccharides. STARCH-STARKE, [10.1002/star.201700064] |
| 26. Donghui Wang, Feng Peng, Jinhua Li, Yuqin Qiao, Qianwen Li, Xuanyong Liu. (2017) Butyrate-inserted Ni–Ti layered double hydroxide film for H2O2-mediated tumor and bacteria killing. Materials Today, [10.1016/j.mattod.2017.05.001] |
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