Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis.
Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity.
Also plays an important role in NK-cells cytotoxicity.
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule.
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content.
Presents carbohydrate ligands to selectins.
(Microbial infection) Acts as a receptor for Lassa virus glycoprotein.
Also promotes fusion of the virus with host membrane in less acidic endosomes.
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.
(Microbial infection) The glycosylation of Asn-76 is essential for Lassa virus entry into cells.
宿主种属
小鼠(Mouse)
特异性
Human LAMP1
种属反应性
人(Human)
免疫原
Recombinant Human CD107a Protein
阳性对照
Flow Cytometry: Jurkat cells
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
1.0 mg/mL
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 7.2
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。
图片
LAMP1 Mouse mAb (Ab187900) - Flow Cytometry
Overlay histogram showing Jurkat cells stained with LAMP1 Mouse mAb (Ab187900) (Red) at 1.25 μg/mL for 1 hour at 4°C. Cells were fixed and permeabilized with 100% methanol. The Goat Anti-Mouse IgG H&L (PE) (Ab179006) was used as the secondary antibody. Unlabeled sample (Black) was used as a negative control. Mouse IgG2b-kappa, anti-E8L (Ab210600) was used as an isotype control (Blue).
ZJ26F0130876
危险品化学品经营许可证（带存储）