计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 13 篇同行评审文献引用。
概述
Forskolin是一种普遍存在的真核细胞腺苷酸环化酶（AC）激活剂，在细胞生理学研究中，常用来提高cAMP水平。An adenylate cyclase activator and MAP kinase inhibitor
Information
Colforsin (Forskolin, HL 362) Colforsin (Forskolin, HL 362, Coleonol, Colforsin) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physi
In vitro
Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin\'s potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin\'s direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma.
In vivo
Cell Data
cell lines：Human gastric cancer cells NCI-N87
Concentrations：
Incubation Time：
Powder Purity:≥97%
规格
英文别名
Coleonol, Colforsin | 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Colforsin (Forskolin, HL 362)
生化机理
科尔福辛（Forskolin、HL 362、Coleonol、Colforsin）是真核腺苷酸环化酶（AC）在多种类型细胞中无处不在的激活剂，在细胞生理学研究中常用于提高 cAMP 水平。佛司可林还能激活 PXR 和 FXR 活性。蕨麻还能刺激自噬。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
266-410-9
分子类型
小分子
Isomeric SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
分子量
410.5
Beilstein号
1692720
Reaxy-Rn
8940142
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8940142&ln=
技术文档
高级数据
关联靶点（人）
RXFP1
Tchem
松弛素受体 1(Relaxin receptor 1)
(1 活性数据)
ADCY8
Tchem
腺苷酸环化酶 8 型(Adenylate cyclase type 8)
(1 活性数据)
ADCY1
Tchem
腺苷酸环化酶 1 型(Adenylate cyclase type 1)
(2 活性数据)
化学和物理性质
溶解性
Solubility (25°C) In vitro
比旋光度
-17°
熔点
224.0 to 228.0°C
安全和危险性（GHS）
象形图
信号词
Warning
危险声明
H312: 皮肤接触有害
预防措施声明
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P302+P352: 如皮肤沾染：用水充分清洗。
P321: 特殊处理（请参阅此标签上的...）。
P501: 将内容物/容器处理到。。。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P317: 寻求紧急医疗救助。
WGK Germany
3
RTECS
QL6150000
Merck Index
2476
个人防护装备
dust mask type N95 (US)， Eyeshields， Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
Hedgehog信号通路
目录： 技术文章
Urinary Follicle-Stimulating Hormone (uFSH): Source Attributes, Molecular Properties, and Research Application Frameworks
目录： 技术文章
Adrenomedullin (ADM): Molecular Features, Signaling Mechanisms, and Research and Translational Applications of a Multisystem Vasoactive Peptide
目录： 技术文章
Famotidine: Physicochemical Features, Mechanism of Action, and Key Points for Research Applications
目录： 技术文章
Review of the Principles, Common Methods, and Key Application Considerations for the Determination of Glycerol and Triglyceride Contents
目录： 技术文章
Glycoprotein Hormone Family: Molecular Features, Signaling Bias, and In Vivo Pharmacokinetics
目录： 技术文章
Central–Peripheral Signaling Networks Regulated by Neuropeptides and the Integration of Energy Metabolism
目录： 技术文章
神经元信号转导机制与疾病研究
目录： 技术文章
Applications of Endocrinology/Hormones in Metabolic Regulation, Reproductive Function, and Disease Research
目录： 技术文章
Roles of GLP-1R, GIPR, and GCGR in Metabolic Regulation of Obesity and Type 2 Diabetes and in Multi-Receptor Agonist Therapy
目录： 技术文章
Molecular Composition, Signal Transduction Mechanisms, and Targeted Regulatory Strategies of the Hippo Signaling Pathway
目录： 技术文章
天然产物调控脂肪褐变的分子机制
目录： 技术文章
此产品的引用文献
溶液计算器
📚 按应用领域分类引用文献
查看全部 13 篇引用 →产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）