I2505066计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
寡霉素A 来源于 淀粉酶产色链霉菌
有货
概述
Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.Oligomycin is used to inhibit membrane bount mitochondrial ATP synthase. It is used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat.
Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.
Oligomycin is used to inhibit membrane bount mitochondrial ATP synthase. It is used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat.
规格
产品名称
寡霉素A 来源于 淀粉酶产色链霉菌
英文别名
MCH 32
规格或纯度
EnzymoPure™, ≥97%
生化机理
奥利霉素可抑制膜结合线粒体 ATP 合成酶（ATP 酶）、质子通道（泵，FO 亚基）阻滞剂，从而抑制氧化磷酸化和电子传递链。ATP 合成酶抑制剂。阻断质子通道（Fo 亚基），解除氧化磷酸化。具有抗肿瘤活性。体内活性
作用类型
抑制剂
CAS编号和信息
579-13-5
分子类型
小分子
储存与运输
物理形态
固体
储存条件
-20°C储存
运输条件
超低温运输
高级数据
三维结构
交互式化学结构模型
关联靶点（人）
SLCO1B1
Tchem
溶质载体有机阴离子转运蛋白家族成员1B1(Solute carrier organic anion transporter family member 1B1)
(0 活性数据)
SLCO1B3
Tchem
溶质载体有机阴离子转运蛋白家族成员1B3(Solute carrier organic anion transporter family member 1B3)
(0 活性数据)
关联靶点（其它种属）
Pseudomonas aeruginosa (123386 活性数据)
Klebsiella pneumoniae (43867 活性数据)
Staphylococcus aureus (210822 活性数据)
Acinetobacter baumannii (41033 活性数据)
Escherichia coli (133304 活性数据)
Cryptococcus neoformans (21258 活性数据)
Candida albicans (78123 活性数据)
Kcnk9
Potassium channel subfamily K member 9 (8 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
质检证书(CoA,COO,BSE/TSE 和分析图谱)
技术文档和文章
Functional System Overview of Cellular Metabolic Enzymes in Energy Metabolism, Redox, and Signal Transduction
目录： 技术文章
Oxidative Stress and Experimental Interpretation Framework for ROS, JC-1, MPTP, and Calcium Indicators in Mitochondrial Function Assessment
目录： 技术文章
Membrane Transporters and Ion Channels: How Transmembrane Substance Flux Drives Cellular Signaling and Functional Regulation
目录： 技术文章
From Metabolic Flux to Protein Degradation: How Metabolic Enzymes and Protein Degradation Systems Jointly Regulate Cell Fate
目录： 技术文章
How Coenzyme Q10 Acts on the Skin: Mitochondrial Electron Transfer, Antioxidant Protection of Membrane Lipids, and Lipid-Carrier Delivery
目录： 技术文章
Structural Characteristics of Ergothioneine, OCTN1-Mediated Uptake by Skin Cells, and Antioxidant Mechanisms
目录： 技术文章
天然产物调控脂肪褐变的分子机制
目录： 技术文章
溶液计算器
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