Alpha TFEB antibody | AlphaTFEB antibody | bHLHe35 antibody | Class E basic helix-loop-helix protein 35 antibody | T cell transcription factor EB antibody | TCFEB antibody | TFEB antibody | TFEB_HUMAN antibody | Transcription factor EB antibody | ALPHATFE
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
宿主种属
兔(Rabbit)
特异性
TFEB
种属反应性
人(Human)
免疫原
Recombinant full length protein (Human).
阳性对照
WB: HeLa, Hep G2 and K562 cell lysates. IHC: Human lung cancer tissues. ICC/IF: HeLa cells.
Recombinant TFEB Antibody (Ab130770) - Western Blot All lanes: Recombinant TFEB Antibody (Ab130770) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 53 kDa Observed band size: 42, 61 kDa Exposure time: 50.0 s
Recombinant TFEB Antibody (Ab130770) - IF/ICC Immunocytochemistry analysis of Transcription Factor EB (green) in HeLa using Recombinant TFEB Antibody (Ab130770), and cells were counterstained with DAPI (blue).
Recombinant TFEB Antibody (Ab130770) - IHC Immunohistochemistry analysis of paraffin-embedded Human lung cancer tissue using Recombinant TFEB Antibody (Ab130770). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F0303530
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