猪源I型胶原(ColI)

CAS: 9007-34-5 货号: C301781 EC号: 232-697-4
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级别和纯度: Moligand™ ? Moligand™ —— 阿拉丁的配体和生物活性小分子系列。适用于需要明确小分子工具的受体、通路和结合研究。 研发级
别名
胶原蛋白
储存条件
-20°C储存
运输条件
超低温运输
★
规格
库存
价格
数量
25mg
C301781-25mg
现货 Stock Image
¥435.90
100mg
C301781-100mg
现货 Stock Image
¥1,338.90
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为什么选择此级别

Moligand™ 级 ,适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 7 篇同行评审文献引用。

概述

产品介绍:
胶原蛋白是生物高分子,动物结缔组织中的主要成分,也是哺乳动物体内含量最多、分布最广的功能性蛋白,占蛋白质总量的25%~30%,某些生物体甚至高达80%以上,胶原蛋白种类较多,常见类型为Ⅰ型、Ⅱ型、Ⅲ型、Ⅴ型和Ⅺ型。I 型胶原蛋白存在于骨骼和肌肤中。其占骨骼有机物质 90% 以上,也是肌肤、肌腱和韧带的主要成分。I 型胶原蛋白最初在细胞中产生时为原胶蛋白前体。该蛋白质由两条前体 α1(I)蛋白链与一条前体 α2(I)胶原蛋白前体链结合而成,形成三链绳状结构。在细胞中时,酶通过添加三链形成稳定分子并在链之间建立连接(交联)所必需的化学基团来修饰蛋白质中的某些氨基酸(赖氨酸和脯氨酸)。其他酶会在蛋白质中添加糖。现已完成,三链 I 型胶原蛋白前体分子离开细胞,并通过酶将两端的小片段剪断。原胶蛋白前体分子在细胞外部排列成细长的原纤维。原纤维并排在一起形成胶原纤维。原纤维中分子之间的交联使得蛋白质结构非常稳定,这有助于胶原蛋白的组织增强功能。

Collagen is an extracellular matrix protein comprising triple helical structure. Homotrimetric collagens have three identical α-chains. Type I collagen have one α-chain different in sequence among the three. Type I collagen was first isolated  has two main α chains (α and α ) and one β chain。

产品用途:
Collagen, Type I  has been used for coating culture plates and dishes for human hepatocyte HepG2 cell line and podocytes. It has also been used as a standard for total collagen content calibration curve generation for the quantification of liver extracellular matrix pre-gel.

Product introduction:
Collagen is an extracellular matrix protein comprising triple helical structure. Homotrimetric collagens have three identical α-chains. Type I collagen have one α-chain different in sequence among the three. Type I collagen was first isolated  has two main α chains (α and α ) and one β chain。
Application:
Collagen, Type I  has been used for coating culture plates and dishes for human hepatocyte HepG2 cell line and podocytes. It has also been used as a standard for total collagen content calibration curve generation for the quantification of liver extracellular matrix pre-gel.

规格

别名
胶原蛋白
英文别名
ColI
规格或纯度
Moligand™, 研发级
英文名称
collagen I from pig
生化机理
胶原蛋白对肌腱和骨骼的机械完整性至关重要。胶原蛋白可用于组织工程,特别是生成基于凝胶的三维支架。胶原蛋白抗原性低,与人类牙龈成纤维细胞和人类口腔角质细胞相容。
储存条件
-20°C储存
运输条件
超低温运输
名称和识别符
PubChem SID
EC号
232-697-4
分子类型
蛋白质
Isomeric SMILES
CCCCNC(=O)C(C)CC(C(CC(C)C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C)O
Reaxy-Rn
25111481
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25111481&ln=

技术文档

📋 安全数据表 (SDS)

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🔬 规格说明书

该级别的完整质量属性和验收标准。

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高级数据

安全和危险性(GHS)
WGK Germany
WGK 1
RIDADR
NONH for all modes of transport
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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找到7个结果

批号(Lot Number) 证书类型 货号
K2224271 分析证书 C301781
F2513348 分析证书 C301781
B2604260 分析证书 C301781
G2616084 分析证书 C301781
L2431099 分析证书 C301781
I2426169 分析证书 C301781
G2228715 分析证书 C301781
技术文档和文章
生物医用聚合物解析:任务角色地图、六大材料旋钮与风险导向证据链(含产品导航与产品表1–表3)
Biomedical Polymer Insights: Role-Based Task Map, Six Key Material Levers, and a Risk-Driven Evidence Chain (including the Product Navigation Guide and Product Tables 1–3)
成纤维细胞生长因子(FGF2)诱导血管生成模型实验操作规程
FGF2-Induced Angiogenesis Model: Standard Operating Procedure (Protocol)
皮肤之下:护肤与医美体系中的蛋白质与肽类活性物质
Beneath the Skin: Protein- and Peptide-Based Actives in Skincare and Aesthetic Medicine
双链脱氧核糖核酸酶(dsDNase)介导的双链DNA水解:酶学特征、方法学策略与生物分析应用综述
dsDNase-Mediated Hydrolysis of Double-Stranded DNA: Enzymatic Characteristics, Methodological Strategies, and Bioanalytical Applications
胶原酶(Collagenase)的酶学特征、类型体系与科研应用综述
Review of Collagenase: Enzymological Features, Type Systems, and Research Applications
羟脯氨酸含量检测的技术比较与方法学选择
Technical Comparison and Method Selection for Hydroxyproline Determination
uPA/uPAR系统与细胞迁移及微环境重构
The uPA/uPAR System in Cell Migration and Microenvironment Remodeling
常用细胞培养包被液的选型逻辑、操作参数与应用边界
Selection Logic, Operating Parameters, and Application Boundaries of Common Cell Culture Coating Solutions
医用水凝胶研发中的关键判断:从聚合物来源、交联方式到灭菌安排、放大可行性与质量控制
Key Judgments in Medical Hydrogel R&D: From Polymer Source and Crosslinking Strategy to Sterilization Planning, Scale-Up Feasibility, and Quality Control
酶促蛋白交联体系在凝胶构建与功能评价中的应用
Applications of Enzymatic Protein Crosslinking Systems in Gel Construction and Functional Evaluation
把水凝胶支架设计成可编程细胞微环境:从点击化学功能化到三维细胞培养实验设计
Designing Hydrogel Scaffolds as Programmable Cell Microenvironments: From Click-Chemistry Functionalization to 3D Cell Culture Experimental Design
血脑屏障通透性评价:示踪剂外渗、TEER 检测与体外模型结果判读
Evaluation of Blood-Brain Barrier Permeability: Tracer Extravasation, TEER Measurement, and Interpretation of In Vitro Model Results
α-硫辛酸的皮肤抗老机制:ALA/DHLA 氧化还原循环、抗氧化网络与胶原 AGEs 形成调控
The Skin Anti-Aging Mechanisms of α-Lipoic Acid: ALA/DHLA Redox Cycling, the Antioxidant Network, and Regulation of Collagen AGE Formation
肌肽与脱羧基肌肽的皮肤抗衰老机制:活性羰基捕获、氧化应激缓冲与胶原糖化交联抑制
Skin Anti-Aging Mechanisms of Carnosine and Decarboxy Carnosine: Active Carbonyl Scavenging, Oxidative-Stress Buffering, and Inhibition of Collagen Glycation Cross-Linking
胶原蛋白肽如何作用于皮肤?从表面水合、经皮递送到成纤维细胞与胶原稳态
How Do Collagen Peptides Act on the Skin? From Surface Hydration and Percutaneous Delivery to Fibroblasts and Collagen Homeostasis
卤虫提取物的抗光老化潜力:紫外线损伤级联反应、HSP70相关应激保护与GP4G代谢线索
Anti-Photoaging Potential of Artemia Extract: UV-Induced Damage Cascades, HSP70-Related Stress Protection, and GP4G Metabolic Insights
纤连蛋白的结构与功能:细胞黏附、皮肤创伤修复与外用应用
Structure and Functions of Fibronectin: Cell Adhesion, Cutaneous Wound Repair, and Topical Applications
棕榈酰五肽-4如何作用于皮肤:从KTTKS序列、皮肤递送到胶原基质响应
How Palmitoyl Pentapeptide-4 Acts on the Skin: From the KTTKS Sequence and Skin Delivery to Collagen Matrix Responses
环化如何改变多肽行为:以Cyclopeptide-5为例解析构象预组织、皮肤递送与整合素结合
How Cyclization Changes Peptide Behavior: Conformational Preorganization, Skin Delivery, and Integrin Binding, Using Cyclopeptide-5 as an Example
胶原三肽如何作用于皮肤:角质层递送、基质保护与胶原稳态调节
How Does Collagen Tripeptide Act on the Skin: Stratum Corneum Delivery, Matrix Protection, and Regulation of Collagen Homeostasis
胶原蛋白的功能由什么决定:从三股螺旋形成到层级组装、交联成熟与动态重塑
What Determines Collagen Function: From Triple-Helix Formation to Hierarchical Assembly, Crosslink Maturation, and Dynamic Remodeling
PDRN参与皮肤修复的机制:A2A受体相关信号、核苷酸补救与细胞外基质重塑
Mechanisms by Which PDRN Participates in Skin Repair: A2A Receptor-Related Signaling, Nucleotide Salvage, and Extracellular Matrix Remodeling
“植物胶原蛋白”是什么:原料类型、结构差异、生产方式与护肤作用辨析
What Is “Plant Collagen”? Distinguishing Ingredient Types, Structural Differences, Production Methods, and Skincare Effects
棕榈酰三肽-1与棕榈酰五肽-4的组合逻辑:皮肤递送、基质信号与胶原稳态调节
The Combination Logic of Palmitoyl Tripeptide-1 and Palmitoyl Pentapeptide-4: Skin Delivery, Matrix Signaling, and Regulation of Collagen Homeostasis
动物源胶原蛋白与重组胶原蛋白在护肤中的差异:序列与结构、安全性、皮肤作用及证据评价
Differences Between Animal-Derived Collagen and Recombinant Collagen in Skincare: Sequence and Structure, Safety, Skin Effects, and Evidence Evaluation
此产品的引用文献
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