Cetuximab (anti-EGFR), 表皮生长因子受体抗体

CAS: 205923-56-4 货号: C411992 分子量: 145543.35
有货
级别和纯度: 无动物源 ? 无动物源(Animal Free)—— 不含动物源成分生产,降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体(Carrier Free)—— 不含添加的载体蛋白/稳定剂。当载体(如 BSA)会干扰偶联或敏感检测时使用。 重组 ? 重组(Recombinant)—— 通过重组表达生产,序列确定、批次稳定。适用于来源明确、无动物源的可重现蛋白。 已验证 ? 已验证级 —— 发布前在特定应用中确认性能。当需要试剂按声称工作的书面保证时使用。 ExactAb™ ? ExactAb™ —— 阿拉丁强调精准和验证质量的抗体系列。适用于可靠、特异性经验证的抗体应用。 低内毒素 ? 低内毒素级 —— 内毒素降至受控低水平。适用于高内毒素会造成干扰的敏感生物工作。 无叠氮钠 ? 无叠氮(Azide Free)—— 不含叠氮化钠防腐剂。适用于叠氮有毒或有抑制作用的偶联、细胞工作或检测。 ≥95%(SDS-PAGE&SEC-HPLC) 见COA
应用
Animal Model, ELISA, Flow Cytometry, Functional Assay
宿主种属
人(Human)
种属反应性
人(Human), 小鼠(Mouse), 食蟹猴(Cynomolgus monkey)
亚型
Human IgG1
偶联
Unconjugated
★
规格
库存
价格
数量
100μg
C411992-100μg
现货 Stock Image
¥359.90
1mg
C411992-1mg
现货 Stock Image
¥1,769.90
5mg
C411992-5mg
现货 Stock Image
¥3,729.90
10mg
C411992-10mg
期货 Stock Image
¥5,999.90
请输入您要添加的产品数量
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为什么选择此级别

ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 2 篇同行评审文献引用。

概述

Cetuximab (anti-EGFR) 是一种人源 IgG1 单克隆抗体,能够抑制 EGFR, Cetuximab (anti-EGFR) 具有高效的抗肿瘤作用。

Cetuximab (anti-EGFR) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR). Cetuximab (anti-EGFR) has potent antitumor activity. 

规格

产品名称
Cetuximab (anti-EGFR), 表皮生长因子受体抗体
别名
西妥昔单抗 | EGFR抗体 | EGFR单克隆抗体 | EGFR药靶抗体 | ERBB1抗体 | ERBB1单克隆抗体 | ERBB1药靶抗体
英文别名
C225 | Recombinant Cetuximab Antibody | Cetuximab (anti-EGFR) | Cetuximab (C225) | Anti-ERBB1 / EGFR / HER1 Reference Antibody (cetuximab) | Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibo
规格或纯度
无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.
宿主种属
人(Human)
特异性
ERBB1/EGFR/HER1
应用
ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性
人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联
Unconjugated
作用类型
抑制剂
作用机制
表皮生长因子受体抗体
抗体类型
Primary antibody
克隆类型
重组抗体
Format
Whole IgG
亚型
Human IgG1
轻链亚型
kappa
纯化方法
Protein A purified
纯度
>95%
来源
CHO supernatant
浓度
见COA
CAS编号和信息
205923-56-4
分子类型
抗体
储存与运输
物理外观
Liquid
储存缓冲液
Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
图片

Cetuximab (anti-EGFR) (C411992) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling EGFR (red) with Cetuximab (anti-EGFR) (C411992). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Cetuximab (anti-EGFR) (C411992) - SEC
The purity of Cetuximab (anti-EGFR) (C411992) is more than 95% verified by HPLC.

Cetuximab (anti-EGFR) (C411992) - ELISA
Immobilized Human EGFR-Fc at 2 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC₅₀ of 10.67 ng/mL.

Cetuximab (anti-EGFR) (C411992) - ELISA
Immobilized Recombinant Human EGFR protein (rp176273) at 1.0 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC50 of 17.44 ng/mL.

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

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🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

关联靶点(人)
EGFR Tclin 表皮生长因子受体(Epidermal growth factor receptor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin MER intracellular domain/EGFR extracellular domain chimera (2 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin Protein cereblon/Epidermal growth factor receptor (191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin EGFR/PPP1CA (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin VHL/EGFR (323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
作用机制
作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到5个结果

批号(Lot Number) 证书类型 货号
ZJ24F0911235 分析证书 C411992
ZJ24F0911238 分析证书 C411992
ZJ23F0901157 分析证书 C411992
ZJ25F0521990 分析证书 C411992
ZJ23F0901156 分析证书 C411992
技术文档和文章
此产品的引用文献
引用文献
1. Liyin Wang, Milad Ashrafizadeh, Gautam Sethi, Xinjia Zhou.  (2025)  pH-responsive biomimetic zeolitic imidazolate framework-based nanoparticles for co-delivery of cetuximab and siRNA in synergistic therapy of laryngeal squamous cell carcinoma.  Journal of Pharmaceutical Analysis,  [PMID:40735032] [10.1016/j.jpha.2025.101203]
2. Li Jinbo, Yu Jiang, Song Jia, Zhang Yingxi, Li Ning, Wang Zhaomeng, Qin Meng, Zhao Mingming, Zhang Baoyue, Huang Ruiping, Zhou Shuang, Liu Yubo, He Zhonggui, Liu Hongzhuo, Dan Liu, Wang Yongjun.  (2025)  Galloylated liposomes enable targeted drug delivery by overcoming protein corona shielding.  Nature Communications,  16  (1): (1-15).  [PMID:40854890] [10.1038/s41467-025-63198-4]
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