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L-苏氨酸

180篇引用文献
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货号 (SKU) 包装规格 是否现货 价格 数量
T652220-25g
 25g 现货 Stock Image
T652220-100g
 100g 现货 Stock Image
T652220-500g
 500g 现货 Stock Image
T652220-1kg
 1kg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
main product photo

基本描述

别名 (2S,3R)-2-氨基-3-羟基丁酸
英文别名 L-2-Amino-3-hydroxybutyrate | NSC46701 | CHEBI:16857 | GTPL4785 | L-THREONINE [JAN] | (2S,3R)-rel-2-Amino-3-hydroxybutanoic acid | AKOS015840277 | THREONINE [WHO-DD] | Threonine, L- (8CI) | L-alpha-Amino-beta-hydroxybutyric acid | Threonine, DL- | bmse000
规格或纯度 Moligand™, 无动物源, 低内毒素, 用于细胞培养, ≥99%
英文名称 L-Threonine
生化机理 L-苏氨酸被认为是一种必需氨基酸。L-苏氨酸参与黏蛋白的合成，黏蛋白是一种支持肠道功能和完整性的蛋白质。L-苏氨酸是免疫系统发挥功能所必需的。对O-连接糖基化、蛋白质磷酸化和甘氨酸合成也是必需的。
储存温度 干燥
运输条件 常规运输
产品介绍

溶于水，不溶于无水乙醇、乙醚和氯仿等大多数有机溶剂。半数致死量(大鼠，腹腔)3098mg/kg.水中溶解度:90 g/L (20°C) L -苏氨酸是一种天然存在的氨基酸，属于天门冬氨酸氨基酸家族。可由微生物发酵产生，可用于食品、药品和饲料中。L-Threonine是一种必需氨基酸，处于活化形式。它对于胶原蛋白、弹性蛋白和牙釉质的形成十分重要，连同天冬氨酸、甲硫氨酸一起发挥滋养肝脏、抗脂肪肝的作用。

L-Threonine is a naturally occurring amino acid belonging to the aspartate family of amino acids.

AI解读

关联靶点（人）

F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc16a10 Monocarboxylate transporter 10 (73 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAP1 General amino-acid permease GAP1 (481 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc1a5 Amino acid transporter (271 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 200-774-1
分子类型 小分子
IUPAC Name (2S,3R)-2-amino-3-hydroxybutanoic acid
INCHI InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
InChi Key AYFVYJQAPQTCCC-GBXIJSLDSA-N
Canonical SMILES CC(C(C(=O)O)N)O
Isomeric SMILES C[C@H]([C@@H](C(=O)O)N)O
RTECS XO8590000
分子量 119.13
Beilstein号 1721646
Reaxy-Rn 1721646

化学和物理性质

溶解性 Soluble in water 50 mg/mL.
比旋光度 -28 ° (C=6, H2O)
熔点 256 °C (dec.) (lit.)
分子量 119.120 g/mol
XLogP3 -2.900
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 119.058 Da
单同位素质量Monoisotopic Mass 119.058 Da
拓扑极表面积Topological Polar Surface Area 83.600 Ų
重原子数Heavy Atom Count 8
形式电荷Formal Charge 0
复杂度Complexity 93.300
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 2
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

RTECS XO8590000
Reaxy-Rn 1721646
Merck Index 9380

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批号(Lot Number) 证书类型 日期 货号
F2428335 分析证书 24-06-19 T652220
F2428336 分析证书 24-06-19 T652220
F2428337 分析证书 24-06-19 T652220
F2428379 分析证书 24-06-19 T652220

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38. Fa-Ting Xie, Yu-Long Li, Tong Yang, Yun-Hui Yang, Rong Hu.  (2022)  Metal–Organic Framework UiO-66-Mediated Dual-Signal Ratiometric Electrochemical Sensor for microRNA Detection with DNA Walker Amplification.  LANGMUIR,  38  (39): (11828–11836).  [PMID:36148509] [10.1021/acs.langmuir.2c00932]
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40. Chunhua Li, Xiao Xu, Fuli Wang, Yue Zhao, Yubo Shi, Xin Zhao, Jue Liu.  (2023)  Portable smartphone platform integrated with paper strip-assisted fluorescence sensor for ultrasensitive and visual quantitation of ascorbic acid.  FOOD CHEMISTRY,  402  (134222).  [PMID:36130432] [10.1016/j.foodchem.2022.134222]
41. Zhengzheng Zhao, Zhifang Wu, Xueling Lin, Fangjie Han, Zhishan Liang, Likun Huang, Mengjiao Dai, Dongxue Han, Lipeng Han, Li Niu.  (2023)  A label-free PEC aptasensor platform based on g-C3N4/BiVO4 heterojunction for tetracycline detection in food analysis.  FOOD CHEMISTRY,  402  (134258).  [PMID:36174353] [10.1016/j.foodchem.2022.134258]
42. Huai Chen, Jiang Xu, Yaping Wang, Da Wang, Raquel Ferrer-Espada, Yutong Wang, Jingjian Zhou, Adrián Pedrazo-Tardajos, Mei Yang, Jia-Heng Tan, Xiaoyu Yang, Lei Zhang, Ilya Sychugov, Shoudeng Chen, Sara Bals, Johan Paulsson, Zhenyu Yang.  (2022)  Color-Switchable Nanosilicon Fluorescent Probes.  ACS Nano,  16  (9): (15450–15459).  [PMID:36107985] [10.1021/acsnano.2c07443]
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58. Fangli Gao, Mengmeng Sun, Jie Zhang, Yi Chang, Weihua Gao, Guanglei Ma, Xiaoming Ma, Yuming Guo.  (2022)  Fenton-like reaction and glutathione depletion by chiral manganese dioxide nanoparticles for enhanced chemodynamic therapy and chemotherapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  616  (369).  [PMID:35220185] [10.1016/j.jcis.2022.02.060]
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