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5,5＇二硫代双(2-硝基苯甲酸)（DTNB）

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货号 (SKU) 包装规格 是否现货 价格 数量
D105559-1g
 1g 现货 Stock Image
D105559-5g
 5g 现货 Stock Image
D105559-10g
 10g 现货 Stock Image
D105559-25g
 25g 现货 Stock Image
D105559-100g
 100g 现货 Stock Image
D105559-500g
 500g 现货 Stock Image
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Biochemical Assay Reagents (985) 有机构建块 (2) 羧酸 (2073) 羰基化合物 (2338)
main product photo

基本描述

别名 双(3-羧基-4-硝基苯基)二硫 | 二硫代硝基苯甲酸 | 6,6'-二硝基-3,3'-二硫代苯甲酸 | DTNB, Ellman 试剂
英文别名 3,3'-Dithiobis(6-nitrobenzoic acid) | DTNB | 5,5'-Disulfanediylbis(2-nitrobenzoic acid) | Ellman's Reagent | Dithionitrobenzoic acid | 3-Carboxy-4-nitrophenyl disulfide | 5,5'-Dithiobis(2-nitrobenzoic acid) | Benzoic acid, 3,3'-dithiobis[6-nitro-Dithiobis
规格或纯度 ≥98%
英文名称 5,5＇-Dithio bis-(2-nitrobenzoic acid)
储存温度 2-8°C储存,干燥
运输条件 冰袋运输
产品介绍

DTNB (Ellman’s 试剂) 常用于蛋白质和生物分子中巯基 (thiol) 的定量测定。

产品应用：

Ellman′s试剂可用于乙酰胆碱酯酶的检测，并可对半胱氨酸残基进行特异性标记。该试剂是测定蛋白质、多肽和组织中游离巯基含量的敏感试剂。 

5,5′-二硫代双(2-硝基苯甲酸)是一种水溶性试剂，主要用于巯基的衍生化。

Ellman's Reagent (DTNB) reacts with sulfhydryl groups to yield a colored product, providing a reliable method to measure reduced cysteines and other free sulfhydryls in solution. Ellman's Reagent (5,5'-dithio-bis-[2-nitrobenzoic acid]) is used to estimate sulfhydryl groups in a sample by comparing to a standard curve of a sulfhydryl-containing compound such as cysteine. Alternatively, sulfhydryl groups can be assayed using the extinction coefficient of TNB (14,150M-1cm-1 at 412nm). Ellman's Reagent has been used for applications other than sulfhydryl estimation, such as for determining alkylthiols by HPLC using a pre-column derivatization procedure and to study thiols in the active site of several enzymes. Highlights: ?Sulfhydryl assay – reacts quantitatively with free (reduced) sulfhydryl groups (–SH) to yield detectable TNB product ?Colorimetric detection – colored product enables spectrophotometric measurement in cuvettes or microplates (λmax = 412nm; ε = 14,150/M?cm) ?Proven method – well-characterized chemistry provides quantitation of peptide or protein sulfhydryl groups using extinction coefficient calculation or by comparison to a cysteine standard
A sensitive reagent for measuring the free sulfhydryl content in proteins, peptides, and tissues.

DTNB (Ellman’s reagent) is commonly used for quantification of sulfhydryl (thiol) groups in proteins and biomolecules.

AI解读

关联靶点（人）

TRPC5 Tchem Short transient receptor potential channel 5 (300 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

tmk Thymidylate kinase (360 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
crn-4 Cell death-related nuclease 4 (18 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rnt Ribonuclease T (18 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504751040
EC号 200-714-4
分子类型 小分子
IUPAC Name 5-[(3-carboxy-4-nitrophenyl)disulfanyl]-2-nitrobenzoic acid
INCHI InChI=1S/C14H8N2O8S2/c17-13(18)9-5-7(1-3-11(9)15(21)22)25-26-8-2-4-12(16(23)24)10(6-8)14(19)20/h1-6H,(H,17,18)(H,19,20)
InChi Key KIUMMUBSPKGMOY-UHFFFAOYSA-N
Canonical SMILES C1=CC(=C(C=C1SSC2=CC(=C(C=C2)[N+](=O)[O-])C(=O)O)C(=O)O)[N+](=O)[O-]
Isomeric SMILES C1=CC(=C(C=C1SSC2=CC(=C(C=C2)[N+](=O)[O-])C(=O)O)C(=O)O)[N+](=O)[O-]
WGK Germany 3
RTECS DG9650000
PubChem CID 6254
分子量 396.35
Beilstein号 1896821
Reaxy-Rn 1896821

化学和物理性质

溶解性 Soluble in 100% ethanol, dioxane, and Phosphate buffer.
密度 1.6412
敏感性 热敏感
熔点 240-245°C
分子量 396.400 g/mol
XLogP3 2.700
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 10
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 395.972 Da
单同位素质量Monoisotopic Mass 395.972 Da
拓扑极表面积Topological Polar Surface Area 217.000 Ų
重原子数Heavy Atom Count 26
形式电荷Formal Charge 0
复杂度Complexity 528.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 3
RTECS DG9650000
Reaxy-Rn 1896821
Merck Index 3551
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

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D2525231 分析证书 25-04-11 D105559
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D2525172 分析证书 25-04-11 D105559
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G2405068 分析证书 23-11-24 D105559
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174. Shumin Zhang, Zhengming Yang, Jican Hao, Fang Ding, Zhiguang Li, Xuehong Ren.  (2022)  Hollow nanosphere-doped bacterial cellulose and polypropylene wound dressings: Biomimetic nanocatalyst mediated antibacterial therapy.  CHEMICAL ENGINEERING JOURNAL,  432  (134309).  [10.1016/j.cej.2021.134309]
175. Cui-Cui Sun, Zhong-Ping Yin, Ji-Guang Chen, Wen-Jun Wang, Guo-Dong Zheng, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang.  (2021)  Dihydromyricetin Improves Cognitive Impairments in d-Galactose-Induced Aging Mice through Regulating Oxidative Stress and Inhibition of Acetylcholinesterase.  MOLECULAR NUTRITION & FOOD RESEARCH,  66  (4): (2101002).  [PMID:34932880] [10.1002/mnfr.202101002]
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177. Xianliang Bao, Xianghui Yan, Guohua Zhang, Junxin Zhao, Zheling Zeng, Ping Yu, Deming Gong.  (2022)  Improving effect of phytase treatment on the functional properties and in vitro digestibility of protein isolate from Cinnamomum camphora seed kernel.  LWT-FOOD SCIENCE AND TECHNOLOGY,  155  (112948).  [10.1016/j.lwt.2021.112948]
178. Zhiqi Zhao, Qiujin Li, Yu Dong, Jixian Gong, Zheng Li, Jianfei Zhang.  (2022)  Core-shell structured gold nanorods on thread-embroidered fabric-based microfluidic device for Ex Situ detection of glucose and lactate in sweat.  SENSORS AND ACTUATORS B-CHEMICAL,  353  (131154).  [10.1016/j.snb.2021.131154]
179. Jihui Gao, Yizhan Guo, Rongrong Yan, Jianfen Liang, Dong Yang.  (2022)  Mechanism differences between reductive and oxidative dough rheology improvers in the formation of 1D and 3D gluten network.  BIOMATERIALS,  280  (121275).  [PMID:34847431] [10.1016/j.biomaterials.2021.121275]
180. Ruoxi Zhao, Rui Zhang, Lili Feng, Yushan Dong, Jialing Zhou, Songnan Qu, Shili Gai, Dan Yang, He Ding, Piaoping Yang.  (2022)  Constructing virus-like SiOx/CeO2/VOx nanozymes for 1064 nm light-triggered mild-temperature photothermal therapy and nanozyme catalytic therapy.  Nanoscale,  14  (2): (361-372).  [PMID:34878482] [10.1039/D1NR06128C]
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182. Xiubin Zhang, Yong Jin, Yufeng Wang, Pei Liang, Minqiang Zou, Suyang Li, Jian Liu, Xiaohua Qi, Xiaohua Zhang, Ziyang Shang, Yan Chen, Qiang Chen.  (2022)  Measurement of trace bisphenol A in drinking water with combination of immunochromatographic detection technology and SERS method.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  267  (120519).  [PMID:34801391] [10.1016/j.saa.2021.120519]
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184. Boyi Niu, Yixian Zhou, Kaixin Liao, Ting Wen, Sixian Lao, Guilan Quan, Xin Pan, Chuanbin Wu.  (2022)  “Pincer movement”: Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles.  Acta Pharmaceutica Sinica B,  12  (2074).  [PMID:35847508] [10.1016/j.apsb.2021.10.013]
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186. Yan Di, Xiang Li, Xiaowen Chang, Ruijuan Gu, Xiang Duan, Fuguo Liu, Xuebo Liu, Yutang Wang.  (2022)  Impact of germination on structural, functional properties and in vitro protein digestibility of sesame (Sesamum indicum L.) protein.  LWT-FOOD SCIENCE AND TECHNOLOGY,  154  (112651).  [10.1016/j.lwt.2021.112651]
187. Hui Xue, Guowen Zhang, Tianfeng Han, Ruiling Li, Huilan Liu, Binghong Gao, Yonggang Tu, Yan Zhao.  (2022)  Improvement of gel properties and digestibility of the water-soluble polymer of tea polyphenol-egg white under thermal treatment.  FOOD CHEMISTRY,  372  (131319).  [PMID:34818739] [10.1016/j.foodchem.2021.131319]
188. Han Chen, Tao Lin, Xiaoshu Yan, Hang Xu.  (2022)  Elevated risk of haloacetonitrile formation during post-chlorination when applying sulfite/UV advanced reduction technology to eliminate bromate.  SCIENCE OF THE TOTAL ENVIRONMENT,  806  (150612).  [PMID:34597579] [10.1016/j.scitotenv.2021.150612]
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190. Xiuquan Yao, Yuming Lai, Feifei Huang, Yujie Qiang, Ying Jin.  (2021)  5,5′-dithiobis-(2-nitrobenzoic acid) self-assembled monolayer for corrosion inhibition of copper in sodium chloride solution.  JOURNAL OF MOLECULAR LIQUIDS,  343  (117535).  [10.1016/j.molliq.2021.117535]
191. Zhang Li, Fan Yadi, Yang Zhe, Yang Mo, Wong Chun-Yuen.  (2021)  NIR-II-driven and glutathione depletion-enhanced hypoxia-irrelevant free radical nanogenerator for combined cancer therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-16).  [PMID:34488803] [10.1186/s12951-021-01003-2]
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200. Xiudan Wang, Yuling Mao, Changshan Sun, Qinfu Zhao, Yikun Gao, Siling Wang.  (2021)  A versatile gas-generator promoting drug release and oxygen replenishment for amplifying photodynamic-chemotherapy synergetic anti-tumor effects.  BIOMATERIALS,  276  (120985).  [PMID:34229242] [10.1016/j.biomaterials.2021.120985]
201. Wanjun Zhang, Jinling Gao, Lin Lu, Tsendmaa Bold, Xin Li, Shuo Wang, Zhishang Chang, Jing Chen, Xiao Kong, Yuxin Zheng, Mingliang Zhang, Jinglong Tang.  (2021)  Intracellular GSH/GST antioxidants system change as an earlier biomarker for toxicity evaluation of iron oxide nanoparticles.  NanoImpact,  23  (100338).  [PMID:35559839] [10.1016/j.impact.2021.100338]
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204. Qiuye Zhang, Jingjing Wang, Luen Xu, Shi-Yu Lu, Huawei Yang, Yifan Duan, Qiang Yang, Mengfan Qiu, Chunmei Chen, Sheng Zhao, Xiaohong Liu, Hui Liu.  (2021)  PEGylated copper(II)-chelated polydopamine nanocomposites for photothermal-enhanced chemodynamic therapy against tumor cells.  JOURNAL OF APPLIED POLYMER SCIENCE,  138  (40): (51172).  [10.1002/app.51172]
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212. Yan Bingsong, Liu Wendong, Duan Guangbin, Ni Pengjuan, Jiang Yuanyuan, Zhang Chenghui, Wang Bo, Lu Yizhong, Chen Chuanxia.  (2021)  Colorimetric detection of acetylcholinesterase and its inhibitor based on thiol-regulated oxidase-like activity of 2D palladium square nanoplates on reduced graphene oxide.  MICROCHIMICA ACTA,  188  (5): (1-9).  [PMID:33839958] [10.1007/s00604-021-04817-x]
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214. Desheng Cao, Hua He, Wei Li, Jin Yan, Jianhua Wu, Mengyuan Yin, Yang Zhou, Zhuchao Zhou, Lichen Yin.  (2021)  A near-infrared light-controlled, oxygen-independent radical generating nano-system toward cancer therapy.  Biomaterials Science,  9  (11): (4054-4065).  [PMID:33908463] [10.1039/D1BM00084E]
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216. Sa Wang, Tingting Hu, Guanyun Wang, Zhengdi Wang, Dan Yan, Ruizheng Liang, Chaoliang Tan.  (2021)  Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy.  CHEMICAL ENGINEERING JOURNAL,  419  (129458).  [10.1016/j.cej.2021.129458]
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218. Sheng-Xiong Chen, Zhi-Jing Ni, Kiran Thakur, Shaoyun Wang, Jian-Guo Zhang, Ya-Fang Shang, Zhao-Jun Wei.  (2021)  Effect of grape seed power on the structural and physicochemical properties of wheat gluten in noodle preparation system.  FOOD CHEMISTRY,  355  (129500).  [PMID:33780794] [10.1016/j.foodchem.2021.129500]
219. Yizhan Guo, Chunfei Zhao, Peixuan Yu, Jihui Gao, Zhongxin Liang, Ruiyang Ji, Haolan Du, Jiahui Fu, Jianfen Liang, Dong Yang.  (2021)  Molecular basis of sodium chloride dominated glutenin interaction and bread properties.  LWT-FOOD SCIENCE AND TECHNOLOGY,  142  (111011).  [10.1016/j.lwt.2021.111011]
220. Peipei Yang, Jia Tao, Fengfeng Chen, Yuying Chen, Jiaqi He, Kui Shen, Peng Zhao, Yingwei Li.  (2021)  Multienzyme-Mimic Ultrafine Alloyed Nanoparticles in Metal Organic Frameworks for Enhanced Chemodynamic Therapy.  Small,  17  (7): (2005865).  [PMID:33502106] [10.1002/smll.202005865]
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222. Liu Xinning, Liu Yuanchang, Zhao Guangjian, Zhang Yidan, Liu Lu, Wang Juan, Wang Yifan, Zhang Siyu, Li Xin, Guo Dongliang, Wang Peng, Xu Ximing.  (2021)  Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus.  Frontiers in Microbiology,  11  [PMID:33537010] [10.3389/fmicb.2020.595083]
223. Yunxiu Liu, Yu Tian, Qiuyang Han, Jie Yin, Junchuan Zhang, Yue Yu, Weizhong Yang, Yi Deng.  (2021)  Synergism of 2D/1D MXene/cobalt nanowire heterojunctions for boosted photo-activated antibacterial application.  CHEMICAL ENGINEERING JOURNAL,  410  (128209).  [10.1016/j.cej.2020.128209]
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225. Xiaohong He, Jun Chen, Xuemei He, Zhi Feng, Changhong Li, Wei Liu, Taotao Dai, Chengmei Liu.  (2021)  Industry-scale microfluidization as a potential technique to improve solubility and modify structure of pea protein.  Innovative Food Science & Emerging Technologies,  67  (102582).  [10.1016/j.ifset.2020.102582]
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217. Ruiling Li, Hui Xue, Binghong Gao, Huilan Liu, Tianfeng Han, Xiaobo Hu, Yonggang Tu, Yan Zhao.  (2022)  Physicochemical properties and digestibility of thermally induced ovalbumin–oil emulsion gels: Effect of interfacial film type and oil droplets size.  FOOD HYDROCOLLOIDS,  131  (107747).  [10.1016/j.foodhyd.2022.107747]
218. Aihong Yang, Wenjing Liu, Xiangyu Li, Wanru Wu, Xiaodi Kou, Rui Shen.  (2022)  Study on the novel usnic acid derivatives: Design, synthesis, X-Ray crystal structure of Cu(II) complex and anti-AD activities.  JOURNAL OF MOLECULAR STRUCTURE,  1263  (133018).  [10.1016/j.molstruc.2022.133018]
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220. Wenquan Huang, Shiyuan Liu, Zhiqiang Li, Yingying Liu, Qiuling Xie, Yanbin Jiang.  (2022)  Analysis of the differences in self-assembly behaviour, molecular structure and drug delivery performance between α and β-Zein.  INDUSTRIAL CROPS AND PRODUCTS,  181  (114822).  [10.1016/j.indcrop.2022.114822]
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222. Feng Wu, Yaqian Du, Jiani Yang, Boyang Shao, Zhensheng Mi, Yuanfei Yao, Ying Cui, Fei He, Yanqiao Zhang, Piaoping Yang.  (2022)  Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death.  ACS Nano,  16  (3): (3647–3663).  [PMID:35266697] [10.1021/acsnano.1c06777]
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225. Hui Xue, Meng Xu, Guowen Zhang, Ping Wang, Lin Yu, Ying Zhao, Yonggang Tu, Yan Zhao.  (2022)  Study on the mechanism of enhanced gel strength of heat-induced egg white by shikimic acid braising.  POULTRY SCIENCE,  101  (101774).  [PMID:35278755] [10.1016/j.psj.2022.101774]
226. Qiaozhi Zhang, Zhijie Huang, Huatao Li, Congnan Cen, Ruixing Zheng, Cao Lili, Shufen Zhang, Yanbo Wang, Linglin Fu.  (2022)  Deciphering Changes in the Structure and IgE-Binding Ability of Ovalbumin Glycated by α-Dicarbonyl Compounds under Simulated Heating.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (6): (1984–1995).  [PMID:35112874] [10.1021/acs.jafc.1c06939]
227. Shujun Tan, Yao Wu, Yang Hou, Haoyu Deng, Xiaoxuan Liu, Shoujuan Wang, Hongping Xiang, Minzhi Rong, Mingqiu Zhang.  (2022)  Waste nitrile rubber powders enabling tougher 3D printing photosensitive resin composite.  POLYMER,  243  (124609).  [10.1016/j.polymer.2022.124609]
228. Wu Hongjiao, Chen Jiaqi, Yang Yi, Yu Weitai, Chen Ying, Lin Pengcheng, Liang Ke.  (2022)  Smartphone-coupled three-layered paper-based microfluidic chips demonstrating stereoscopic capillary-driven fluid transport towards colorimetric detection of pesticides.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  414  (5): (1759-1772).  [PMID:35059790] [10.1007/s00216-021-03839-x]
229. Guoqing Zhu, Pan Zheng, Man Wang, Weilin Chen, Chunxia Li.  (2022)  A novel CuCoS nanozyme for synergistic photothermal and chemodynamic therapy of tumors.  Inorganic Chemistry Frontiers,  9  (5): (1006-1015).  [10.1039/D1QI01563J]
230. Jia Liu, Wei Ha, Hai-Xia Zhang, Yan-Ping Shi.  (2022)  Hollow urchin-shaped manganese dioxide microspheres immobilized acetylcholinesterase for rapid screening inhibitors from traditional herbal medicines.  JOURNAL OF CHROMATOGRAPHY A,  1665  (462824).  [PMID:35051752] [10.1016/j.chroma.2022.462824]
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232. Ang Li, Lei Chen, Weijie Zhou, Junhui Pan, Deming Gong, Guowen Zhang.  (2022)  Effects of Baicalein and Chrysin on the Structure and Functional Properties of β-Lactoglobulin.  Foods,  11  (2): (165).  [PMID:35053897] [10.3390/foods11020165]
233. Pengfei Yan, Mengya Li, Jie Liu, Yadi Hu, Keyong Tang.  (2022)  MoS2@PDA@Ag/PVA Hybrid Hydrogel with Excellent Light-Responsive Antibacterial Activity and Enhanced Mechanical Properties for Wound Dressing.  MACROMOLECULAR MATERIALS AND ENGINEERING,  307  (2): (2100654).  [10.1002/mame.202100654]
234. Bin Liu, Yulong Bian, Shuang Liang, Meng Yuan, Shuming Dong, Fei He, Shili Gai, Piaoping Yang, Ziyong Cheng, Jun Lin.  (2022)  One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy.  ACS Nano,  16  (1): (617–630).  [PMID:34957819] [10.1021/acsnano.1c07893]
235. Ning Zhang, Zhicheng Deng, Qiang Wang, Man Zhou, Ping Wang, Yuanyuan Yu.  (2022)  Phase-transited lysozyme with secondary reactivity for moisture-permeable antibacterial wool fabric.  CHEMICAL ENGINEERING JOURNAL,  432  (134198).  [10.1016/j.cej.2021.134198]
236. Shumin Zhang, Zhengming Yang, Jican Hao, Fang Ding, Zhiguang Li, Xuehong Ren.  (2022)  Hollow nanosphere-doped bacterial cellulose and polypropylene wound dressings: Biomimetic nanocatalyst mediated antibacterial therapy.  CHEMICAL ENGINEERING JOURNAL,  432  (134309).  [10.1016/j.cej.2021.134309]
237. Cui-Cui Sun, Zhong-Ping Yin, Ji-Guang Chen, Wen-Jun Wang, Guo-Dong Zheng, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang.  (2021)  Dihydromyricetin Improves Cognitive Impairments in d-Galactose-Induced Aging Mice through Regulating Oxidative Stress and Inhibition of Acetylcholinesterase.  MOLECULAR NUTRITION & FOOD RESEARCH,  66  (4): (2101002).  [PMID:34932880] [10.1002/mnfr.202101002]
238. Shumin Zhang, Jican Hao, Fang Ding, Xuehong Ren.  (2022)  Nanocatalyst doped bacterial cellulose-based thermosensitive nanogel with biocatalytic function for antibacterial application.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  195  (294).  [PMID:34914907] [10.1016/j.ijbiomac.2021.12.020]
239. Xianliang Bao, Xianghui Yan, Guohua Zhang, Junxin Zhao, Zheling Zeng, Ping Yu, Deming Gong.  (2022)  Improving effect of phytase treatment on the functional properties and in vitro digestibility of protein isolate from Cinnamomum camphora seed kernel.  LWT-FOOD SCIENCE AND TECHNOLOGY,  155  (112948).  [10.1016/j.lwt.2021.112948]
240. Zhiqi Zhao, Qiujin Li, Yu Dong, Jixian Gong, Zheng Li, Jianfei Zhang.  (2022)  Core-shell structured gold nanorods on thread-embroidered fabric-based microfluidic device for Ex Situ detection of glucose and lactate in sweat.  SENSORS AND ACTUATORS B-CHEMICAL,  353  (131154).  [10.1016/j.snb.2021.131154]
241. Jihui Gao, Yizhan Guo, Rongrong Yan, Jianfen Liang, Dong Yang.  (2022)  Mechanism differences between reductive and oxidative dough rheology improvers in the formation of 1D and 3D gluten network.  BIOMATERIALS,  280  (121275).  [PMID:34847431] [10.1016/j.biomaterials.2021.121275]
242. Ruoxi Zhao, Rui Zhang, Lili Feng, Yushan Dong, Jialing Zhou, Songnan Qu, Shili Gai, Dan Yang, He Ding, Piaoping Yang.  (2022)  Constructing virus-like SiOx/CeO2/VOx nanozymes for 1064 nm light-triggered mild-temperature photothermal therapy and nanozyme catalytic therapy.  Nanoscale,  14  (2): (361-372).  [PMID:34878482] [10.1039/D1NR06128C]
243. Sujuan Zhang, Zheng Wang, Irum Rafique, Zaijun Lu.  (2022)  Room-temperature fast-curing polybenzoxazine hybrid thermosets via UV irradiation.  EUROPEAN POLYMER JOURNAL,  162  (110871).  [10.1016/j.eurpolymj.2021.110871]
244. Xiubin Zhang, Yong Jin, Yufeng Wang, Pei Liang, Minqiang Zou, Suyang Li, Jian Liu, Xiaohua Qi, Xiaohua Zhang, Ziyang Shang, Yan Chen, Qiang Chen.  (2022)  Measurement of trace bisphenol A in drinking water with combination of immunochromatographic detection technology and SERS method.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  267  (120519).  [PMID:34801391] [10.1016/j.saa.2021.120519]
245. Yidan Zhang, Xuebing Zhang, Zhiheng Zhang, Zhenjia Chen, Xu Jing, Xiaowen Wang.  (2022)  Effect of high hydrostatic pressure treatment on the structure and physicochemical properties of millet gliadin.  LWT-FOOD SCIENCE AND TECHNOLOGY,  154  (112755).  [10.1016/j.lwt.2021.112755]
246. Boyi Niu, Yixian Zhou, Kaixin Liao, Ting Wen, Sixian Lao, Guilan Quan, Xin Pan, Chuanbin Wu.  (2022)  “Pincer movement”: Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles.  Acta Pharmaceutica Sinica B,  12  (2074).  [PMID:35847508] [10.1016/j.apsb.2021.10.013]
247. Boyi Niu, Kaixin Liao, Yixian Zhou, Ting Wen, Guilan Quan, Chuanbin Wu, Xin Pan.  (2021)  Cellular defense system-destroying nanoparticles as a platform for enhanced chemotherapy against drug-resistant cancer.  Materials Science & Engineering C-Materials for Biological Applications,  131  (112494).  [PMID:34857280] [10.1016/j.msec.2021.112494]
248. Yan Di, Xiang Li, Xiaowen Chang, Ruijuan Gu, Xiang Duan, Fuguo Liu, Xuebo Liu, Yutang Wang.  (2022)  Impact of germination on structural, functional properties and in vitro protein digestibility of sesame (Sesamum indicum L.) protein.  LWT-FOOD SCIENCE AND TECHNOLOGY,  154  (112651).  [10.1016/j.lwt.2021.112651]
249. Hui Xue, Guowen Zhang, Tianfeng Han, Ruiling Li, Huilan Liu, Binghong Gao, Yonggang Tu, Yan Zhao.  (2022)  Improvement of gel properties and digestibility of the water-soluble polymer of tea polyphenol-egg white under thermal treatment.  FOOD CHEMISTRY,  372  (131319).  [PMID:34818739] [10.1016/j.foodchem.2021.131319]
250. Han Chen, Tao Lin, Xiaoshu Yan, Hang Xu.  (2022)  Elevated risk of haloacetonitrile formation during post-chlorination when applying sulfite/UV advanced reduction technology to eliminate bromate.  SCIENCE OF THE TOTAL ENVIRONMENT,  806  (150612).  [PMID:34597579] [10.1016/j.scitotenv.2021.150612]
251. Hui Xue, Meng Xu, Guowen Zhang, Feng Feng, Yuting Wang, Danhui Cao, Yonggang Tu, Yan Zhao.  (2021)  Effects of stewing with tea polyphenol on the gel properties, microstructure, and secondary structure of boiled egg white.  JOURNAL OF FOOD SCIENCE,  86  (10): (4262-4274).  [PMID:34564852] [10.1111/1750-3841.15919]
252. Xiuquan Yao, Yuming Lai, Feifei Huang, Yujie Qiang, Ying Jin.  (2021)  5,5′-dithiobis-(2-nitrobenzoic acid) self-assembled monolayer for corrosion inhibition of copper in sodium chloride solution.  JOURNAL OF MOLECULAR LIQUIDS,  343  (117535).  [10.1016/j.molliq.2021.117535]
253. Zhang Li, Fan Yadi, Yang Zhe, Yang Mo, Wong Chun-Yuen.  (2021)  NIR-II-driven and glutathione depletion-enhanced hypoxia-irrelevant free radical nanogenerator for combined cancer therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-16).  [PMID:34488803] [10.1186/s12951-021-01003-2]
254. Hui-Peng Song, Hui Zhang, Rui Hu, Hong-He Xiao, Hua Guo, Wei-Hong Yuan, Xin-Tong Han, Xin-Yi Xu, Xin Zhang, Zi-Xuan Ding, Ming-Yue Zhao, Ting-Guo Kang, Hui-Yang Sun, An Chang, Yue-Hua Chen, Ming Xie.  (2021)  A strategy to discover lead chemome from traditional Chinese medicines based on natural chromatogram-effect correlation (NCEC) and natural structure-effect correlation (NSEC): Mahonia bealei and Mahonia fortunei as a case study.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1181  (122922).  [PMID:34500403] [10.1016/j.jchromb.2021.122922]
255. Lanlan Wu, Jianhua Li, Weijing Wu, Libo Wang, Fei Qin, Wen Xie.  (2021)  Effect of extraction pH on functional properties, structural properties, and in vitro gastrointestinal digestion of tartary buckwheat protein isolates.  JOURNAL OF CEREAL SCIENCE,  101  (103314).  [10.1016/j.jcs.2021.103314]
256. Chen Ruipeng, Li Shuang, Sun Yunfeng, Huo Bingyang, Xia Yating, Qin Yingkai, Li Shuning, Shi Baodi, He Defu, Liang Jun, Gao Zhixian.  (2021)  Surface-enhanced Raman spectroscopy aptasensor for simultaneous determination of ochratoxin A and zearalenone using Au@Ag core-shell nanoparticles and gold nanorods.  MICROCHIMICA ACTA,  188  (8): (1-9).  [PMID:34331147] [10.1007/s00604-021-04919-6]
257. Ze Zhang, Yang Xu, Bochen Ma, Zhanfang Ma, Hongliang Han.  (2021)  A novel electrochemical sensor based on process-formed laccase-like catalyst to degrade polyhydroquinone for tumor marker.  TALANTA,  235  (122736).  [PMID:34517604] [10.1016/j.talanta.2021.122736]
258. Qian-Da Xu, Zhi-Long Yu, Wei-Cai Zeng.  (2021)  Structural and functional modifications of myofibrillar protein by natural phenolic compounds and their application in pork meatball.  FOOD RESEARCH INTERNATIONAL,  148  (110593).  [PMID:34507738] [10.1016/j.foodres.2021.110593]
259. Xing Li, Shaoquan Bian, Mingda Zhao, Xiaowen Han, Jie Liang, Kefeng Wang, Qing Jiang, Yong Sun, Yujiang Fan, Xingdong Zhang.  (2021)  Stimuli-responsive biphenyl-tripeptide supramolecular hydrogels as biomimetic extracellular matrix scaffolds for cartilage tissue engineering.  Acta Biomaterialia,  131  (128).  [PMID:34245894] [10.1016/j.actbio.2021.07.007]
260. Zongping Wang, Lisan Cao, Ying Wan, Jingwen Wang, Fan Bai, Pengchao Xie.  (2021)  Enhanced degradation of tetrabromobisphenol A by Fe3+/sulfite process under simulated sunlight irradiation.  CHEMOSPHERE,  285  (131442).  [PMID:34256205] [10.1016/j.chemosphere.2021.131442]
261. Ji Li, Chenlu Shi, Wenbin Zeng, Yaru Wang, Zebin Hong, Yibing Ma, Liping Fang.  (2022)  Distinct roles of pH and organic ligands in the dissolution of goethite by cysteine.  Journal of Environmental Sciences,  113  (260).  [PMID:34963535] [10.1016/j.jes.2021.06.011]
262. Xiudan Wang, Yuling Mao, Changshan Sun, Qinfu Zhao, Yikun Gao, Siling Wang.  (2021)  A versatile gas-generator promoting drug release and oxygen replenishment for amplifying photodynamic-chemotherapy synergetic anti-tumor effects.  BIOMATERIALS,  276  (120985).  [PMID:34229242] [10.1016/j.biomaterials.2021.120985]
263. Wanjun Zhang, Jinling Gao, Lin Lu, Tsendmaa Bold, Xin Li, Shuo Wang, Zhishang Chang, Jing Chen, Xiao Kong, Yuxin Zheng, Mingliang Zhang, Jinglong Tang.  (2021)  Intracellular GSH/GST antioxidants system change as an earlier biomarker for toxicity evaluation of iron oxide nanoparticles.  NanoImpact,  23  (100338).  [PMID:35559839] [10.1016/j.impact.2021.100338]
264. Qiang Chu, Linhua Liao, Bin Liu, Gaorong Han, Xiang Li.  (2021)  Sulfite-Inserted MgAl Layered Double Hydroxides Loaded with Glucose Oxidase to Enable SO2-Mediated Synergistic Tumor Therapy.  ADVANCED FUNCTIONAL MATERIALS,  31  (33): (2103262).  [10.1002/adfm.202103262]
265. Fei-Yue Xu, Qing-Hui Wen, Rui Wang, Jian Li, Bo-Ru Chen, Xin-An Zeng.  (2021)  Enhanced synthesis of succinylated whey protein isolate by pulsed electric field pretreatment.  FOOD CHEMISTRY,  363  (129892).  [PMID:34120044] [10.1016/j.foodchem.2021.129892]
266. Qiuye Zhang, Jingjing Wang, Luen Xu, Shi-Yu Lu, Huawei Yang, Yifan Duan, Qiang Yang, Mengfan Qiu, Chunmei Chen, Sheng Zhao, Xiaohong Liu, Hui Liu.  (2021)  PEGylated copper(II)-chelated polydopamine nanocomposites for photothermal-enhanced chemodynamic therapy against tumor cells.  JOURNAL OF APPLIED POLYMER SCIENCE,  138  (40): (51172).  [10.1002/app.51172]
267. Mianhong Chen, Xingrong Ren, Liming Dong, Xiaohe Li, Haiming Cheng.  (2021)  Preparation of dynamic covalently crosslinking keratin hydrogels based on thiol/disulfide bonds exchange strategy.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  182  (1259).  [PMID:33991559] [10.1016/j.ijbiomac.2021.05.057]
268. Liu Chao, Zhao Yunmeng, Xu Di, Zheng Xinxin, Huang Qing.  (2021)  A green and facile approach to a graphene-based peroxidase-like nanozyme and its application in sensitive colorimetric detection of l-cysteine.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (15): (4013-4022).  [PMID:33961104] [10.1007/s00216-021-03352-1]
269. Hailing Gao, Jingjing Xu, Mengna Tan, Dongdong Mu, Xingjiang Li, Yanyan Zhao, Zhi Zheng.  (2021)  Effect of high-intensity ultrasound soymilk pretreatment on the physicochemical properties of microbial transglutaminase-catalyzed tofu gel.  JOURNAL OF FOOD SCIENCE,  86  (6): (2410-2420).  [PMID:33904174] [10.1111/1750-3841.15735]
270. Hua Guo, Yue-Hua Chen, Tian-Min Wang, Ting-Guo Kang, Hui-Yang Sun, Wen-Han Pei, Hui-Peng Song, Hui Zhang.  (2021)  A strategy to discover selective α-glucosidase/acetylcholinesterase inhibitors from five function-similar citrus herbs through LC-Q-TOF-MS, bioassay and virtual screening.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1174  (122722).  [PMID:33992880] [10.1016/j.jchromb.2021.122722]
271. Yangbin Peng, Ying Ren, Hao Zhu, Yu An, Baisong Chang, Taolei Sun.  (2021)  Ultrasmall copper nanoclusters with multi-enzyme activities.  RSC Advances,  11  (24): (14517-14526).  [PMID:35424001] [10.1039/D1RA01410B]
272. Xiaodi Kou, Juanjuan Liu, Yuhong Chen, Aihong Yang, Rui Shen.  (2021)  Emodin derivatives with multi-factor anti-AD activities: AChE inhibitor, anti-oxidant and metal chelator.  JOURNAL OF MOLECULAR STRUCTURE,  1239  (130459).  [10.1016/j.molstruc.2021.130459]
273. Lin Yu, Hui Xue, Chunhong Xiong, Xiaojuan Xin, Ping Wang, Feng Feng, Danhui Cao, Yonggang Tu, Yan Zhao.  (2021)  Characterization of duck egg white gel under the action of baijiu (Chinese liquor).  LWT-FOOD SCIENCE AND TECHNOLOGY,  147  (111487).  [10.1016/j.lwt.2021.111487]
274. Yan Bingsong, Liu Wendong, Duan Guangbin, Ni Pengjuan, Jiang Yuanyuan, Zhang Chenghui, Wang Bo, Lu Yizhong, Chen Chuanxia.  (2021)  Colorimetric detection of acetylcholinesterase and its inhibitor based on thiol-regulated oxidase-like activity of 2D palladium square nanoplates on reduced graphene oxide.  MICROCHIMICA ACTA,  188  (5): (1-9).  [PMID:33839958] [10.1007/s00604-021-04817-x]
275. Yufei Yang, Shudong He, Yi Zhang, Xingjiang Li, Haiyan Liu, Qiming Li, Xiaodong Cao, Yongkang Ye, Hanju Sun.  (2021)  Comparison of crude prolamins from seven kidney beans (Phaseolus vulgaris L.) based on composition, structure and functionality.  FOOD CHEMISTRY,  357  (129748).  [PMID:33892353] [10.1016/j.foodchem.2021.129748]
276. Desheng Cao, Hua He, Wei Li, Jin Yan, Jianhua Wu, Mengyuan Yin, Yang Zhou, Zhuchao Zhou, Lichen Yin.  (2021)  A near-infrared light-controlled, oxygen-independent radical generating nano-system toward cancer therapy.  Biomaterials Science,  9  (11): (4054-4065).  [PMID:33908463] [10.1039/D1BM00084E]
277. Li Zhang, Zhe Yang, Wenshan He, Jinghua Ren, Chun-Yuen Wong.  (2021)  One-pot synthesis of a self-reinforcing cascade bioreactor for combined photodynamic/chemodynamic/starvation therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  599  (543).  [PMID:33964699] [10.1016/j.jcis.2021.03.173]
278. Sa Wang, Tingting Hu, Guanyun Wang, Zhengdi Wang, Dan Yan, Ruizheng Liang, Chaoliang Tan.  (2021)  Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy.  CHEMICAL ENGINEERING JOURNAL,  419  (129458).  [10.1016/j.cej.2021.129458]
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