2-Deoxy-D-glucose (2-DG) 2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits He
In vitro

2-Deoxy-D-glucose(2-DG) activates AKT function through phosphatidylinositol 3-kinase (PI3K) and is independent of glycolysis or mTOR inhibition. 2-DG treatments disrupts the binding between insulin-like growth factor 1 (IGF-1) and IGF-binding protein 3 (IGFBP3) so that the free form of IGF-1 could be released from the IGF-1·IGFBP3 complex to activate IGF-1 receptor (IGF1R) signaling. 2-DG-induced activation of many survival pathways can be jointly attenuated through IGF1R inhibition. 2-DG also induces time- and dose-dependent ERK phosphorylation. 2-DG is readily transported into cells and is phosphorylated by hexokinase, but cannot be metabolized further and accumulates in the cell. This leads to ATP depletion and the induction of cell-death. 2DG significantly suppresses proliferation, causes apoptosis and reduces migration of murine endothelial cells, inhibiting formation of lamellipodia and filopodia and causing disorganization of F-actin filaments in murine endothelial cell.

In vivo

Treatment of cancer patients with relatively high doses of 2-DG (greater than 200 mg/kg) was largely ineffective in managing tumor growth. Side effects of 2-DG included elevated blood glucose levels, progressive weight loss with lethargy, and behavioral symptoms of hypoglycemia. 2-DG enhances isoflurane-induced loss of righting reflex in mice. By reducing metabolism, 2-DG treatment can decrease body temperature in rodent, enhancing sensitivity to anesthetics. 2-DG diet significantly increased serum ketone body level and brain expression of enzymes required for ketone body metabolism. The 2-DG-induced maintenance of mitochondrial bioenergetics was paralleled by simultaneous reduction in oxidative stress. Further, 2-DG treated mice exhibited a significant reduction of both amyloid precursor protein (APP) and amyloid beta (Aβ) oligomers, which was paralleled by significantly increased α-secretase and decreased γ-secretase expression, indicating that 2-DG induced a shift towards a non-amyloidogenic pathway. 2-DG increased expression of genes involved in Aβ clearance pathways, degradation, sequestering, and transport. Concomitant with increased bioenergetic capacity and reduced β-amyloid burden, 2-DG significantly increased expression of neurotrophic growth factors, BDNF and NGF, thus reduces pathology in female mouse model of Alzheimer\'s disease.
Cell Data

cell lines：BT20, U87MG, and SKOV3 cells

Concentrations：5 mM

Incubation Time：48 h

Powder Purity:

规格

英文别名

2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose | D-arabino-Hexose, 2-deoxy-

规格或纯度

10mM in DMSO

英文名称

2-Deoxy-D-glucose (2-DG)

生化机理

2-脱氧-D-葡萄糖（2-DG、2-脱氧葡萄糖、NSC 15193、2-脱氧-D-阿拉伯-2-脱氧己糖）是一种葡萄糖类似物，是一种具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导细胞凋亡并抑制 1 型单纯疱疹病毒（HSV-1）受体的表达。

储存条件

-80℃储存

运输条件

特低温运输

名称和识别符

EC号

205-823-0

分子类型

小分子

Isomeric SMILES

C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O

分子量

164.16

Beilstein号

1723331

Reaxy-Rn

2041872

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2041872&ln=

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

化学和物理性质

溶解性

Solubility (25°C) In vitro DMSO: 100 mg/mL (165.95 mM); Water: Insoluble; Ethanol: 100 mg/mL

比旋光度

46.5 ° (C=1, H2O)

熔点

146-147°C

安全和危险性（GHS）

WGK Germany

RTECS

MQ3325000

Merck Index

2904

个人防护装备

Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

研究用碳水化合物（Carbohydrates）入门：读懂“糖链语言”与产品选型导航（附表1–3）

目录：技术文章

探索主题:

碳水化合物

An Introduction to Research-Grade Carbohydrates: Decoding the “Glycan Language” and a Product-Selection Guide (with Tables 1–3)

目录：技术文章

探索主题:

Carbohydrates

葡萄糖含量检测：检测原理、方法学验证与科研应用体系化综述

目录：技术文章

探索主题:

HPLC 葡萄糖己糖激酶比色法代谢组学荧光法 LC-MS 含量检测葡萄糖氧化酶 GOD-POD 电化学传感同位素示踪

Glucose Content Determination: A Systematic Review of Detection Principles, Method Validation, and Research Application Frameworks

目录：技术文章

探索主题:

HPLC Glucose Hexokinase Metabolomics LC-MS GOD-POD content determination glucose oxidase colorimetry fluorimetry electrochemical sensing isotope tracing

细胞代谢酶在能量代谢、氧化还原与信号转导中的功能体系综述

目录：技术文章

探索主题:

氧化还原 NADPH ROS 信号转导代谢酶能量代谢 NADH/NAD+ 代谢物信号通量分析

Functional System Overview of Cellular Metabolic Enzymes in Energy Metabolism, Redox, and Signal Transduction

目录：技术文章

探索主题:

REDOX NADPH ROS Signal Transduction metabolic enzymes energy metabolism NADH/NAD metabolite signaling flux analysis

神经肽调控的中枢—外周信号网络及能量代谢整合

目录：技术文章

探索主题:

脂质代谢神经肽能量代谢中枢—外周信号网络下丘脑脑干摄食调控产热葡萄糖稳态肠—脑轴

Central–Peripheral Signaling Networks Regulated by Neuropeptides and the Integration of Energy Metabolism

目录：技术文章

探索主题:

Lipid metabolism Neuropeptides energy metabolism Central–Peripheral Signaling Network Hypothalamus Brainstem Feeding Regulation Thermogenesis Glucose Homeostasis Gut–Brain Axis

表观遗传酶的非经典功能与线粒体代谢调控

目录：技术文章

探索主题:

表观遗传酶非经典功能线粒体代谢 mtDNA 线粒体蛋白乙酰化 DNMT1 MOF LSD1

Noncanonical Functions of Epigenetic Enzymes and Regulation of Mitochondrial Metabolism

目录：技术文章

探索主题:

mtDNA DNMT1 MOF LSD1 epigenetic enzymes noncanonical functions mitochondrial metabolism mitochondrial protein acetylation

三维染色质结构重塑与生理性衰老机制

目录：技术文章

探索主题:

三维染色质生理性衰老 A/B区室拓扑相关结构域染色质环核纤层相关结构域异染色质

Three-Dimensional Chromatin Architecture Remodeling and Mechanisms of Physiological Aging

目录：技术文章

探索主题:

three-dimensional chromatin physiological aging A/B compartments topologically associating domains chromatin loops lamina-associated domains heterochromatin

铁死亡与免疫代谢互作的分子基础

目录：技术文章

探索主题:

GPX4 铁死亡脂质过氧化免疫代谢 SLC7A11 FSP1 NCOA4

Molecular Basis of Ferroptosis-Immune Metabolism Crosstalk

目录：技术文章

探索主题:

GPX4 SLC7A11 FSP1 NCOA4 ferroptosis immunometabolism lipid peroxidation CD8+ T cells

糖代谢酶月光功能在复制程序、DNA损伤修复与炎症激活中的研究进展

目录：技术文章

探索主题:

GAPDH 糖代谢酶月光功能复制程序 DNA损伤修复炎症激活 PKM2 ENO1

Research Progress on the Moonlighting Functions of Carbohydrate-Metabolic Enzymes in Replication Programs, DNA Damage Repair, and Inflammatory Activation

目录：技术文章

探索主题:

GAPDH PKM2 ENO1 carbohydrate-metabolic enzymes moonlighting functions replication programs DNA damage repair inflammatory activation

脑梗的神经病理机制

目录：技术文章

探索主题:

氧化应激神经炎症血脑屏障脑梗死缺血性脑卒中神经病理机制缺血半暗带兴奋性毒性

Neuropathological Mechanisms of Cerebral Infarction

目录：技术文章

探索主题:

Oxidative Stress neuroinflammation blood-brain barrier cerebral infarction ischemic stroke neuropathological mechanism ischemic penumbra excitotoxicity

糖尿病动物模型建立与评价方法

目录：技术文章

探索主题:

糖尿病动物造模 STZ诱导模型四氧嘧啶模型高脂饮食模型 HFD+STZ模型 NOD小鼠 db/db小鼠 ZDF大鼠

Establishment and Evaluation Methods of Diabetic Animal Models

目录：技术文章

探索主题:

diabetic animal modeling STZ-induced model alloxan model high-fat diet model HFD+STZ model NOD mice db/db mice ZDF rats

蛋白质翻译后修饰的调控机制、研究方法与修饰组学分析

目录：技术文章

探索主题:

糖基化质谱分析甲基化蛋白质翻译后修饰泛素化 SUMO化磷酸化乙酰化乳酸化修饰蛋白质组学

Regulatory Mechanisms, Research Methods, and Modification-Omics Analysis of Protein Post-Translational Modifications

目录：技术文章

探索主题:

Glycosylation methylation SUMOylation Protein Post-Translational Modifications Ubiquitination Phosphorylation Acetylation Lactylation Modification Proteomics

从代谢流到蛋白质降解：代谢酶与蛋白质降解系统如何共同调控细胞命运

目录：技术文章

探索主题:

蛋白酶代谢酶

From Metabolic Flux to Protein Degradation: How Metabolic Enzymes and Protein Degradation Systems Jointly Regulate Cell Fate

目录：技术文章

探索主题:

proteases metabolic enzymes Cell fate

天然产物调控脂肪褐变的分子机制

目录：技术文章

探索主题:

天然产物 AMPK 脂肪褐变白色脂肪组织 UCP1 PGC-1α Hyperforin 颤抖性产热