计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 80 篇同行评审文献引用。
概述
α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.
(+)-α-Tocopherol has been used:
as a food supplement for juvenile cobia fish
to evaluate its protective effect on bisphenol A induced oxidative stress in rats
to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats
α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.
(+)-α-Tocopherol has been used:
as a food supplement for juvenile cobia fish
to evaluate its protective effect on bisphenol A induced oxidative stress in rats
to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats
规格
别名
D-维生素E | 2,5,7,8-四甲基-2-(4',8',12'-三甲基十三烷基)-6-苯并二氢吡喃醇, 5,7,8-三甲基母育酚
英文别名
VITAMIN E | alpha-Tocopherol | D-alpha-Tocopherol | 59-02-9 | 5,7,8-Trimethyltocol | (+)-alpha-Tocopherol | Phytogermine | TOCOPHEROL | 2074-53-5 | Aquasol E | (R,R,R)-alpha-Tocopherol | Syntopherol | Viteolin | Eprolin | Esorb | a-Tocopherol | (2R,4'R,8'R)-alpha-Tocopherol | Tocopherol a
规格或纯度
10mM in DMSO
英文名称
D-α-Tocopherol
生化机理
维生素E形式。抗氧化剂。增加肿瘤细胞凋亡。在体内显示出抗癌，神经保护和肝保护作用。口服具有活性
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
PubChem SID
EC号
200-412-2
分子类型
小分子
IUPAC Name
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
INCHI
1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
InChi Key
GVJHHUAWPYXKBD-IEOSBIPESA-N
Smiles
CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
Isomeric SMILES
CC1=C(C2=C(CC[C@@](O2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=C1O)C)C
关联CAS
分子量
430.72
Beilstein号
17(5)4,168
Reaxy-Rn
1296133
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1296133&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 脂质和脂质样分子 |
| 类（Class) | 异戊烯醇脂质 |
| 亚类（Subclass） | 醌和对苯二酚脂质 |
| 中间层级节点（Intermediate Tree Nodes） | 维生素 E 化合物 |
| 直接上位类(Direct Parent) | 生育酚 |
| 其他上位类（Alternative Parents） | 二萜类化合物 1-苯并吡喃 烷基芳基醚 苯类化合物 氧环化合物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 芳香族杂多环化合物 |
| 取代基（Substituents） | 1-苯并吡喃 - 芳基醚 - 芳香族杂多环化合物 - 苯基化合物 - 苯并吡喃 - 铬烷 - 二萜类化合物 - 乙醚 - 烃衍生物 - 有机氧化合物 - 有机杂环化合物 - 有机氧化合物 - 氧杂环 - 生育酚 |
| 描述（Description） | 该化合物属于生育酚类有机化合物。这类维生素E衍生物在苯并吡喃环系的C6碳原子上连接有饱和三甲基十三烷基链，与含不饱和三甲基十三烷-3,7,11-三烯-1-基链的生育三烯酚存在结构差异。 |
| 外部描述符（External Descriptors） | Vitamin E |
三维结构
交互式化学结构模型
关联靶点（人）
GSTP1
Tchem
谷胱甘肽S转移酶P(Glutathione S-transferase P)
(1 活性数据)
PDE5A
Tclin
Phosphodiesterase 5A
(5113 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
HMGCR
Tclin
HMG-CoA reductase
(2475 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
INSR
Tclin
Insulin receptor
(5558 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
ALOX5
Tclin
Arachidonate 5-lipoxygenase
(6568 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
ACE
Tclin
Angiotensin-converting enzyme
(1423 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
DRD4
Tchem
Dopamine D4 receptor
(7907 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
ADRA1D
Tclin
Alpha-1d adrenergic receptor
(4171 活性数据)
HTR1B
Tclin
Serotonin 1b (5-HT1b) receptor
(2801 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
CALCR
Tclin
Calcitonin receptor
(2215 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
ADRA1B
Tclin
Alpha-1b adrenergic receptor
(2912 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
HTR4
Tclin
Serotonin 4 (5-HT4) receptor
(2068 活性数据)
ESR2
Tclin
Estrogen receptor beta
(9272 活性数据)
CYSLTR1
Tclin
Cysteinyl leukotriene receptor 1
(2118 活性数据)
ERBB2
Tclin
Receptor protein-tyrosine kinase erbB-2
(7851 活性数据)
CHRM4
Tclin
Muscarinic acetylcholine receptor M4
(6041 活性数据)
CHRM5
Tclin
Muscarinic acetylcholine receptor M5
(4677 活性数据)
关联靶点（其它种属）
Agtr2
Angiotensin II type 2 (AT-2) receptor (803 活性数据)
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Ltc4s
Leukotriene C4 synthase (1 活性数据)
Sigmar1
Sigma opioid receptor (160 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Nos2
Nitric oxide synthase, inducible (3573 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Ptpn1
Protein-tyrosine phosphatase 1B (270 活性数据)
Mmp9
Matrix metalloproteinase 9 (38 活性数据)
Salmonella typhimurium (15756 活性数据)
Escherichia coli (133304 活性数据)
Mycobacterium tuberculosis (203094 活性数据)
Gallus gallus (1187 活性数据)
Cavia porcellus (23802 活性数据)
Canis familiaris (36305 活性数据)
Bos taurus (956 活性数据)
Oryctolagus cuniculus (11301 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
Vero (26788 活性数据)
NIH3T3 (5395 活性数据)
HT-22 (3261 活性数据)
J774 (3120 活性数据)
V79 (1637 活性数据)
LOX1.1
Seed lipoxygenase-1 (463 活性数据)
Syrian golden hamster (1610 活性数据)
Brain (1 活性数据)
Mycobacterium tuberculosis variant bovis BCG (1626 活性数据)
Mapt
Microtubule-associated protein tau (6 活性数据)
Scn2a
Sodium channel alpha subunits; brain (Types I, II, III) (344 活性数据)
Liver microsome (341 活性数据)
Glra2
Glycine receptor (1745 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
敏感性
对光线敏感; 对空气敏感
折光率
1.51
比旋光度
0.5° (C=1,EtOH)
闪点(℉)
230 °F
闪点(℃)
110 °C
沸点
200-220 °C/0.1 mmHg (lit.)
熔点
4°C(lit.)
分子量
430.700 g/mol
XLogP3
10.700
氢键供体数Hydrogen Bond Donor Count
1
氢键受体数Hydrogen Bond Acceptor Count
2
可旋转键计数Rotatable Bond Count
12
精确质量Exact Mass
430.381 Da
单同位素质量Monoisotopic Mass
430.381 Da
拓扑极表面积Topological Polar Surface Area
29.500 Ų
重原子数Heavy Atom Count
31
形式电荷Formal Charge
0
复杂度Complexity
503.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
3
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H317: 可能引起皮肤过敏反应
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P272: 被污染的工作服不允许离开工作场所
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P501: 将内容物/容器处理到。。。
RTECS
DJ2900000
Merck Index
9495
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 H2617607 |
分析证书 | D424929 |
技术文档和文章
A Practical Guide to Fragrance Compositions: Turning a Black-Box Formula into an Engineerable System—Compatibility, Stability, Controlled Release, Traceability, and Selection
目录： 技术文章
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目录： 技术文章
Fatty Acids from Basics to Lab Practice: Structural Classification, Research Uses, and Selection Tips (with an Aladdin Representative Product Quick-Reference Table)
目录： 技术文章
Benzopyran Family at a Glance: From the Core Scaffold to Three High-Frequency Applications (Photochromism / Drug Scaffolds / Fluorescence) — with Product Selection Logic and Product Tables (Tables 1–3)
目录： 技术文章
Review of the Structural Characteristics, Biological Functions, and Application Advances of Lycopene
目录： 技术文章
Why Limonene Can Soften Greasy Soils Yet Is Difficult to Dissolve in Water: Understanding the Cleaning Mechanism and Formulation Applications of Naturally Derived Solvents from Molecular Structure
目录： 技术文章
Mechanistic Analysis of Topical Glutathione in Skincare: Cellular Redox Regulation, Skin Delivery Challenges, and SLN-Based Delivery Strategies
目录： 技术文章
The Skin Anti-Aging Mechanisms of α-Lipoic Acid: ALA/DHLA Redox Cycling, the Antioxidant Network, and Regulation of Collagen AGE Formation
目录： 技术文章
Tocopherols in the Vitamin E Family: How They Block the Chain Reaction of Lipid Peroxidation in Skin Lipids
目录： 技术文章
Analysis of Hydrolyzed Pearl as a Cosmetic Raw Material: Preparation Process, Active Components, and Skincare Formulation Applications
目录： 技术文章
Antioxidant Mechanisms, Stability, and Delivery Strategies of Resveratrol in Skincare Research
目录： 技术文章
Antioxidant Mechanisms of Ferulic Acid in Skincare, Vitamin C/E Synergy, and Stable Delivery Applications
目录： 技术文章
Skin Anti-Aging Mechanisms of Carnosine and Decarboxy Carnosine: Active Carbonyl Scavenging, Oxidative-Stress Buffering, and Inhibition of Collagen Glycation Cross-Linking
目录： 技术文章
Molecular Structure, Photochemical Behavior, and Role of Octocrylene in Sunscreen Formulations
目录： 技术文章
How Do Collagen Peptides Act on the Skin? From Surface Hydration and Percutaneous Delivery to Fibroblasts and Collagen Homeostasis
目录： 技术文章
Protective and Potential Reparative Mechanisms of Prinsepia utilis Seed Oil on the Skin Barrier: Fatty Acid Composition, Epidermal Lipid Metabolism, and Research Evidence
目录： 技术文章
Phenylethyl Resorcinol (377): Structural Characteristics, Melanogenesis-Regulating Mechanisms, and Related Applications in Formulation Research
目录： 技术文章
UVA Absorption Mechanism of Avobenzone: Keto–Enol Tautomerism, Photochemical Instability, and Formulation Photostabilization Strategies
目录： 技术文章
Anti-Photoaging Potential of Artemia Extract: UV-Induced Damage Cascades, HSP70-Related Stress Protection, and GP4G Metabolic Insights
目录： 技术文章
Potential Mechanisms of Tea Polyphenols in Oily, Acne-Prone Skin: Effects of EGCG on Sebum Production, Lipid Peroxidation, and Inflammatory Responses
目录： 技术文章
How to Bypass α-Fluoride Elimination: Bromine-Transfer Capture and Oxidative Coupling of α,α-Difluorobenzylic Anions
目录： 技术文章
Mechanisms of Retinol Action in the Skin: From Metabolic Activation and RAR/RXR-Mediated Transcriptional Regulation to Epidermal Renewal and Collagen Homeostasis
目录： 技术文章
Mechanisms by Which PDRN Participates in Skin Repair: A2A Receptor-Related Signaling, Nucleotide Salvage, and Extracellular Matrix Remodeling
目录： 技术文章
此产品的引用文献
溶液计算器
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