计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
有货
为什么选择此级别
生物染色剂 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 42 篇同行评审文献引用。
概述
苏木精是从南美的苏木（热带豆科植物）干枝中用乙醚浸制出来的一种色素，是最常用的染料之一。苏木精不能直接染色，必须暴露在通气的地方，使他变成氧化苏木精（又叫苏木素）后才能使用，这叫做“成熟”。苏木精的“成熟”过程需时较长，配置后时间愈久，染色力愈强。被染材料必须经金属盐作媒剂作用后才有着色力。所以在配制苏木精染剂时都要用媒染剂。常用的媒染剂有硫酸铝按、钾明矾和铁明矾等。水溶性SOLUBLE IN HOT WATER。 易溶于酒精，微溶于水和甘油，易溶于热水和热乙醇，溶于碱、氨和硼砂的溶液。 是染细胞核和染色质的染色剂。定性检定铜(II)、铁(III)、钼酸盐、铋(III)和锡(IV)等。光度测定钒、铝、锡(IV)、氟、铌、钽等。墨水制造。酸碱指示剂,pH 5.0(黄)～6.0(紫)、0.0(粉红)～1.0(绿)。
苏木精是从墨水树（Heamatoxylum campechianum）中提取的嗜碱性染料。它可与酸性化合物特异性结合，因此可用于染色含有酸性物质的细胞核：DNA和RNA。苏木精被氧化后会形成苏木素，呈浅蓝紫色。在光学显微镜下的组织学研究中，苏木精经常与曙红一起使用。
应用：
核和染色质的染色剂。定性检定铜(II)、铁(III)、钼酸盐、铋(III)和锡(IV)等。光度测定钒、铝、锡(IV)、氟、铌、钽等。墨水制造。酸碱指示剂,pH 5.0(黄)～6.0(紫)、0.0(粉红)～1.0(绿)。
苏木精已用于：
可视化解剖特，检测脑干样品中与导水管周围灰色区域相邻的核蓝斑核
用作核复染剂用苏木精试剂复染脂肪细胞可视化核
染色肺组织以进行组织学分析
苏木精已用于对胃癌组织、心肌组织、心脏切片和卵巢核进行染色。
Hematoxylin is a basophilic dye extracted from the tree Heamatoxylum campechianum. It specifically binds to acidic compounds and thus is useful for staining cell nuclei which contain acidic substances: DNA and RNA. Hematoxylin, when oxidized forms hematein, which has thick pale blue purple colour. Hematoxylin is often used along with eosin, in histological study under light microscope.
Application：
Hematoxylin has been used:
to visualize anatomical features and to detect nucleus locus coeruleus adjacent to the periaqueductal gray region in brainstem samples
as a nuclear counterstain to visualize the nucleus, adipocytes were counterstained with a hematoxylin reagent
to stain lung tissue for histological analysis
规格
别名
苏木色精,苏木色素 | 苏木色精 | 苏木色素 | 苏木素 | (6aS,11bR)-6,6a,7,11b-四氢茚并[2,1-c]苯并吡喃-3,4,6a,9,10-五醇
英文别名
Hematoxylin, for microscopy (Hist.), indicator (pH 5.0-6.0) | NSC 270085 | NCGC00160144-01 | Q1146112 | NCI-C55889 | HSDB 4174 | Natural Black 1 | CHEBI:38384 | Hydroxybrasilin | LMPK12100063 | DTXSID8020678 | WZUVPPKBWHMQCE-XJKSGUPXSA-N | (Z)-2-dodecened
规格或纯度
生物染色剂
英文名称
Hematoxylin
生化机理
用来染色细胞核的染料。
储存条件
室温
运输条件
常规运输
名称和识别符
PubChem SID
EC号
208-237-3
分子类型
小分子
IUPAC Name
(6aS,11bR)-7,11b-dihydro-6H-indeno[2,1-c]chromene-3,4,6a,9,10-pentol
INCHI
1S/C16H14O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,13,17-21H,5-6H2/t13-,16+/m0/s1
InChi Key
WZUVPPKBWHMQCE-XJKSGUPXSA-N
Smiles
C1C2=CC(=C(C=C2C3C1(COC4=C3C=CC(=C4O)O)O)O)O
Isomeric SMILES
C1C2=CC(=C(C=C2[C@H]3[C@@]1(COC4=C3C=CC(=C4O)O)O)O)O
分子量
302.28(as Anhydrous)
Beilstein号
17(2)273
Reaxy-Rn
91399
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=91399&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机杂环化合物 |
| 类（Class) | 苯并吡喃类 |
| 亚类（Subclass） | 1-苯并吡喃 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 1-苯并吡喃 |
| 其他上位类（Alternative Parents） | Indanes 烷基芳基醚 1-羟基-4-未取代苯类化合物 1-羟基-2-未取代苯类化合物 叔醇 多元醇 氧环化合物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 芳香族杂多环化合物 |
| 取代基（Substituents） | 1-苯并吡喃 - 1-羟基-2-未取代苯环化合物 - 1-羟基-4-未取代苯环化合物 - 羟基苯甲酸酯 - 芳基醚 - 芳香族杂多环化合物 - 苯基化合物 - 乙醚 - 烃衍生物 - 茚烷 - 有机氧化合物 - 有机氧化合物 - 氧杂环 - 多醇 - 三烷基醇 |
| 描述（Description） | 该化合物属于有机化合物中的1-苯并吡喃类。这类芳香族有机化合物以1-苯并吡喃为结构核心——该双环化合物由苯环与吡喃环共轭而成，氧原子位于1位。 |
| 外部描述符（External Descriptors） | Neoflavonoids |
三维结构
交互式化学结构模型
关联靶点（人）
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
ERBB2
Tclin
Receptor protein-tyrosine kinase erbB-2
(7851 活性数据)
KIT
Tclin
Stem cell growth factor receptor
(10667 活性数据)
FGFR2
Tclin
Fibroblast growth factor receptor 2
(3405 活性数据)
FGFR1
Tclin
Fibroblast growth factor receptor 1
(9149 活性数据)
SRC
Tclin
Tyrosine-protein kinase SRC
(10310 活性数据)
FLT1
Tclin
Vascular endothelial growth factor receptor 1
(6262 活性数据)
KDR
Tclin
Vascular endothelial growth factor receptor 2
(20924 活性数据)
MET
Tclin
Hepatocyte growth factor receptor
(10718 活性数据)
EPHB2
Tchem
Ephrin type-B receptor 2
(1899 活性数据)
MOLT-4
(49676 活性数据)
APEX1
Tchem
DNA-(apurinic or apyrimidinic site) lyase
(38016 活性数据)
TDP1
Tchem
Tyrosyl-DNA phosphodiesterase 1
(345557 活性数据)
KDM4E
Tchem
Lysine-specific demethylase 4D-like
(40243 活性数据)
RECQL
Tbio
ATP-dependent DNA helicase Q1
(5575 活性数据)
HPGD
Tchem
15-hydroxyprostaglandin dehydrogenase [NAD+]
(24926 活性数据)
SLCO1B1
Tchem
Solute carrier organic anion transporter family member 1B1
(2672 活性数据)
SLCO1B3
Tchem
Solute carrier organic anion transporter family member 1B3
(2517 活性数据)
RUNX1
Tbio
Runt-related transcription factor 1/Core-binding factor subunit beta
(7867 活性数据)
关联靶点（其它种属）
Mapk1
MAP kinase ERK2 (650 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Pkm
Pyruvate kinase isozymes M1/M2 (66 活性数据)
Human immunodeficiency virus 1 (70413 活性数据)
Pxn
Paxillin (2 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Mapt
Microtubule-associated protein tau (6 活性数据)
fba
Putative fructose-1,6-bisphosphate aldolase (15559 活性数据)
ffp
4'-phosphopantetheinyl transferase ffp (24982 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
溶于ethanol, 最高浓度 (mg/mL): 0.91, 最高浓度(mM): 3
密度
1.709
敏感性
对光敏感
熔点
200°C
分子量
302.280 g/mol
XLogP3
1.200
氢键供体数Hydrogen Bond Donor Count
5
氢键受体数Hydrogen Bond Acceptor Count
6
可旋转键计数Rotatable Bond Count
0
精确质量Exact Mass
302.079 Da
单同位素质量Monoisotopic Mass
302.079 Da
拓扑极表面积Topological Polar Surface Area
110.000 Ų
重原子数Heavy Atom Count
22
形式电荷Formal Charge
0
复杂度Complexity
444.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
2
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H302: 吞食有害
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P271: 仅在室外或通风良好的地方使用。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P330: 漱口
P302+P352: 如皮肤沾染：用水充分清洗。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P501: 将内容物/容器处理到。。。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P301+P317: 如果被吞咽：请寻求医疗帮助。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
RTECS
MH7875000
Merck Index
4637
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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显示更多⌵
技术文档和文章
生物染色剂
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目录： 技术文章
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目录： 实验方案（Protocols）
Physicochemical Properties, Staining Mechanisms, and Practical Application Specifications of Hematoxylin
目录： 技术文章
Methodological essentials for mineralization visualization: Alizarin Red S staining vs. Von Kossa silver staining
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此产品的引用文献
引用文献
| 1. Wei Chen, Haotian Yu, Chengbiao Sun, Mingxin Dong, Na Zhao, Yan Wang, Kaikai Yu, Jianxu Zhang, Na Xu, Wensen Liu. (2023) γ-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin α5. TOXICOLOGY LETTERS, [PMID:37392970] [10.1016/j.toxlet.2023.06.009] |
| 2. Zhaowei Wen, Huiying Sun, Zhihua Zhang, Yannan Zheng, Siting Zheng, Jianping Bin, Yulin Liao, Min Shi, Rui Zhou, Wangjun Liao. (2023) High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway. Cancer Communications, 43 (5): (562-581). [PMID:37031362] [10.1002/cac2.12420] |
| 3. Yifei Jiang, Qinghe Wu, Mengfei Hou, Wangxi Hai, Min Zhang, Biao Li, Chunfu Zhang. (2023) pH-sensitive gold nanoclusters labeling with radiometallic nuclides for diagnosis and treatment of tumor. Materials Today Bio, [PMID:36880082] [10.1016/j.mtbio.2023.100578] |
| 4. Yi Li, Wenyan She, Tangxi Guo, Tianhe Huang, Yixin liu, Pan Liu, Xiaoran Xu, Xinyu Wang, Miao Wang, Chaochao Yu, Yi Liu, Yongchang Wei. (2022) The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress. BIOCHEMICAL PHARMACOLOGY, [PMID:36592709] [10.1016/j.bcp.2022.115404] |
| 5. Kaihao Wang, Min Zhou, Youhong Zhang, Yipeng Du, Peixin Li, Chang Guan, Zheng Huang. (2022) IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli. INTERNATIONAL JOURNAL OF CARDIOLOGY, [PMID:36181956] [10.1016/j.ijcard.2022.09.070] |
| 6. Weifang Wang, Yunfeng Li, Guojing Han, Aimin Li, Xiaomei Kong. (2022) Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression. Frontiers in Nutrition, [PMID:35911120] [10.3389/fnut.2022.931427] |
| 7. Zining Hao, Yuchu He, Jing Wang, Xuwu Zhang, Fei Ye, Ze Guan, Xiaokang Liu, Zhenhe Ma, Yi Yuan, Hongming Lou, Dawei Gao. (2022) Photocatalysis/enzymolysis-based biomimetic Schottky junction reduces tumor interstitial solid and fluid phases for deep-penetrating tumor therapy. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2022.137196] |
| 8. Chen Pan, Wu Hao, Yao Hongliang, Zhang Jiashuo, Fan Weiyang, Chen Zhen, Su Weiwei, Wang Yonggang, Li Peibo. (2022) Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats. Frontiers in Immunology, [PMID:35432311] [10.3389/fimmu.2022.847132] |
| 9. Zhengrong Yin, Xiangli Zhang, Yan Bai, Yanwei Yang, Bin Liu, Zengjie Fan. (2022) Dissolvable and layered microneedles composed of hyaluronate/rbFGF/CPC effectively improve the treatment effect on recurrent aphthous ulcers. NEW JOURNAL OF CHEMISTRY, 46 (15): (7279-7289). [10.1039/D2NJ00054G] |
| 10. Xiaoping Wu, Qiujie Pang, Fuxiang Zhi, Xiaohong Mao, Yingbin Hu. (2022) Overexpression of long non-coding RNA ACTA2-AS1 inhibits the viability, proliferation, migration and invasion of colorectal cancer cells. TISSUE & CELL, [PMID:35325674] [10.1016/j.tice.2022.101769] |
| 11. Hao Cheng, Zijun Jiang, Chenkai Sun, Zhen Wang, Guochen Han, Xin Chen, Tianyi Li, Zhechen Fan, Feng Zhang, Xiaoyu Yang, Lingyu Lv, Huaqing Zhang, Jianping Zhou, Yang Ding. (2021) Protein stabilized polymeric nanoparticles inspired relay drug delivery for tackling post-chemotherapeutic metastasis. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2021.131672] |
| 12. Ke Wang, Huina Hu, Wenbo Cui, Xuelian Zhang, Qi Tang, Nuan Liu, Xianyong Lan, Chuanying Pan. (2021) Palliative effects of metformin on testicular damage induced by triptolide in male rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, [PMID:34303043] [10.1016/j.ecoenv.2021.112536] |
| 13. Rong Shen, Yichang Yu, Rong Lan, Ran Yu, Ze Yuan, Zhining Xia. (2019) The cardiovascular toxicity induced by high doses of gatifloxacin and ciprofloxacin in zebrafish. ENVIRONMENTAL POLLUTION, [PMID:31454568] [10.1016/j.envpol.2019.07.029] |
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