聚（乙二醇）（PEG）

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 3253 篇同行评审文献引用。

概述

聚乙二醇（PEG）是一种亲水性聚合物。它可以通过环氧乙烷的阴离子开环聚合反应而进行合成，产生不同的分子量和端基。当交联成网络时，PEG可具有高含水量，形成“水凝胶”。聚乙二醇（PEG）不会引发免疫反应，是一种理想的生物学应用材料。

应用：

聚乙二醇(PEG)可与非离子表面活性剂吐温80共同官能化修饰磁性纳米颗粒。聚乙二醇官能化可增强磁纳米颗粒的生物相容性。还能降低表面电荷，维持纳米颗粒的磁性；聚乙二醇可用作药物最终剂型的外部包衣，为原料药提供防潮保护。例如，drop printing（液滴打印）技术可使聚乙二醇包覆在萘普生固体分散体上。PEG包衣可保护固体分散体，避免潮湿导致的结晶加快，并增强稳定性；以聚乙二醇作为有机改性剂，通过溶胶-凝胶技术可制备纳米结构的羟磷灰石(HAP)。聚乙二醇可影响羟磷灰石形态。高温下，柔性更高的聚乙二醇分子形成更大的羟基磷灰石片。低温下，柔性较低的聚乙二醇胶体形成纳米结构的羟磷灰石；聚乙二醇还可作为泻药使用。

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. PEG is a suitable material for biological applications because it does not trigger an immune response.

Application：

Poly (ethylene glycol) (PEG) can be used to functionalize magnetic nanoparticles in combination with nonionic surfactant Tween 80. PEG functionalization improves the biocompatibility of magnetite nanoparticles. It also reduces the surface charge and maintains the magnetic characteristics of nanoparticles. PEG can be used as an exterior coating for the pharmaceutical final dosage forms. This can avoid moisture from encountering active pharmaceutical ingredients. For example, Naproxen solid dispersions are coated with PEG by drop printing technique. The PEG layer protects the solid dispersions from moisture-accelerated crystallization and enhances their stability. Nanostructured hydroxyapatite (HAP) can be prepared by a sol-gel technique using PEG as an organic modifier. The addition of PEG has an influence on the morphology of HAP particles. At high temperatures, more flexible PEG molecules result in the formation of large-sized HAP platelets. At low synthesis temperatures, less flexible PEG colloids form nanostructured HAP. PEG powder can also be used as a laxative agent.