阿拉丁小分子抑制剂、激动剂、拮抗剂--DNA损伤/DNA修复信号通路（上）

DNA损伤/DNA修复

人类细胞中的DNA每天会受到数以万计的外源性损伤（化学污染、紫外线、电离辐射、烷基化/甲基化等引起）和内源性损伤（碱的氧化、烷基化、水解等引起）。损伤后DNA会发生单链和双链断裂，未修复的DNA损伤会导致细胞衰老、凋亡和恶性肿瘤等等。为了避免此类情况，激发了细胞的DNA损伤反应（DDR）。DNA损伤反应（DDR）能够检测DNA的损伤并介导其修复，包含DNA损伤、细胞周期停滞、DNA复制调控、DNA损伤修复旁路等一系列通路的调控，以维持基因组的稳定性和细胞活力。异常的DNA损伤反应与衰老、癌症和免疫疾病有关。

DNA损伤/DNA修复通路转导过程

当DNA受到外源性或内源性损伤后，会发生单链和双链断裂，DNA损伤反应会被激活。

DNA双链断裂激活DNA-PK与ATM/ATR激酶。DNA-PK诱导DNA修复，涉及错配、碱基切除、核苷酸切除修复等多种机制。RPA、Rad51和fanconi贫血蛋白等也可直接用于DNA修复。ATM/ATR激酶经过两个并行级联最终将CyclinB-cdc2复合体失活：1）ATM/ATR激酶激活Chk2激酶，Chk2激酶磷酸化并使失活Cdc25，同时也通过Chk1抑制Cdc25，从而阻止cdc2的激活，快速抑制细胞有丝分裂从G2期进入M期。此外，ATR通过刺激Cdk1抑制激酶Wee1来抑制Cyclinb/Cdk1的激活，防止DNA损伤的细胞进入有丝分裂。2）另一级联反应稍慢，Chk2激酶磷酸化p53，使其从MDM2和MDM4(MdmX)上分离，激活p53下游调节基因，从而抑制CyclinB-cdc2复合体活性或将其从细胞核中排出。p300/PCAF对p53乙酰化可进一步增强其转录能力。同时，p53也可诱导细胞凋亡。

DNA单链断裂后，激活ATR激酶，ATR通过Chk1进一步激活Cdc25A。Cdc25A是一种CDK2激活所需的磷酸酶。CDK2抑制周期素E/A，使有丝分裂无法从G1期进入S期。

DNA损伤/DNA修复信号通路图

产品列表

*HDAC

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	Ki
V125336	Vorinostat	≥99.0%	149647-78-9	100mg,500mg,1g,5g	无细胞	HDAC	~10 nM
E125068	Entinostat (MS-275)	≥98%	209783-80-2	10mg,50mg,100mg,250mg	无细胞	HDAC1	0.51 μM
E125068	Entinostat (MS-275)	≥98%	209783-80-2	10mg,50mg,100mg,250mg	无细胞	HDAC3	1.7 μM
P125167	Panobinostat (LBH589)	≥98%	404950-80-7	10mg,50mg	无细胞	HDAC	5 nM
T129665	Trichostatin A	≥98%	58880-19-6	5mg,10mg,50mg	无细胞	HDAC	1.8 nM
M126151	Mocetinostat (MGCD0103)	≥98%	726169-73-9	5mg,25mg,50mg	无细胞	HDAC1	0.15 μM
B126780	Belinostat (PXD101)	≥98%	414864-00-9	10mg,50mg,250mg	无细胞	HDAC	27 nM
R125265	Romidepsin (FK228, Depsipeptide)	≥98%	128517-07-7	1mg,5mg	无细胞	HDAC1	36 nM
R125265	Romidepsin (FK228, Depsipeptide)	≥98%	128517-07-7	1mg,5mg	无细胞	HDAC2	47 nM
M127417	MC1568	≥97%(HPLC)	852475-26-4	10mg,25mg	无细胞	HDAC	100 nM
T129677	Tubastatin A HCl	≥98%	1310693-92-5	5mg,10mg,50mg,	无细胞	HDAC6	15 nM
G129672	Givinostat (ITF2357)	≥95%	732302-99-7	1mg,5mg,10mg,50mg	无细胞	HD2	10 nM
						HD1B	7.5 nM
						HD1A	16 nM
C127191	CUDC-101	≥98%	1012054-59-9	10mg,25mg,50mg,100mg,250mg		HDAC	4.4 nM
						EGFR	2.4 nM
						HER2	15.7 nM
P127910	Pracinostat (SB939)	≥98%	929016-96-6	5mg,10mg,50mg		pan-HDAC	40-140 nM
P126351	PCI-34051	≥98%	950762-95-5	10mg,50mg	无细胞	HDAC8	10 nM
D127578	Droxinostat	≥96%	99873-43-5	1mg,5mg,10mg,25mg		HDACs 6	2.47μM
D127578	Droxinostat	≥96%	99873-43-5	1mg,5mg,10mg,25mg		HDACs 8	1.46 μM
P126975	PCI-24781 (Abexinostat)	≥97%	783355-60-2	1mg,5mg,10mg,50mg		HDAC1		7 nM
R129686	RGFP966	≥98%	1396841-57-8	5mg,25mg,100mg	无细胞	HDAC3	0.08μM
A127913	AR-42	≥99%	935881-37-1	1mg,2mg,5mg,10mg,50mg		HDAC	30 nM
A124886	Rocilinostat (ACY-1215)	≥98%	1316214-52-4	5mg,10mg,50mg	无细胞	HDAC6	5 nM
S161023	2-丙戊酸钠	≥98.0%	1069-66-5	5g,25g,100g,500g
C126432	CI-994	≥98%	112522-64-2	10mg,50mg,250mg		HDAC1	0.9 μM
						HDAC2	0.9 μM
						HDAC3	1.2 μM
						HDAC8	>20 μM
C126527	CUDC-907	≥99%	1339928-25-4	1mg,5mg,10mg,50mg		PI3Kα	19 nM
						HDAC1	1.7 nM
						HDAC2	5 nM
						PI3Kα和HDAC3	1.8 nM
						PI3Kα和HDAC10	2.8 nM
S102956	丁酸钠	99%,用于生物学	156-54-7	5g,25g,100g,500g
S102954	丁酸钠	98%	156-54-7	25g,100g,250g,500g
C140600	姜黄素	≥65%	458-37-7	5g,25g,100g		HDAC	100 nM
C110685	姜黄素	分析标准品	458-37-7	20mg		HDAC	100 nM
R127721	RG2833	≥98%	1215493-56-3	5mg,10mg,25mg,50mg,100mg	无细胞	HDAC1	60 nM
R127721	RG2833	≥98%	1215493-56-3	5mg,10mg,25mg,50mg,100mg	无细胞	HDAC3	50 nM
S125104	Scriptaid	≥99%	287383-59-9	1mg,5mg
V298968	丙戊酸	≥98.0%	99-66-1	25ml,100ml,500ml		HDAC1	0.4 mM
T125086	Tasquinimod	≥99%	254964-60-8	5mg,10mg,50mg		HDAC4
C168062	Crotonoside	95% (HPLC)	1818-71-9	5mg,10mg,25mg		FLT3
C168062	Crotonoside	95% (HPLC)	1818-71-9	5mg,10mg,25mg		HDAC3/6
S135494	软木肟酸	95%	38937-66-5	1g,5g		HDAC1	0.25 μM
S135494	软木肟酸	95%	38937-66-5	1g,5g		HDAC3	0.3 μM
S161350	斯普利特麻一辛	>98.0%(GC)	5690-03-9	200mg,1g		Sir2p	60 μM
B151913	4-联苯磺酰氯	>98.0%(GC)	1623-93-4	5g,25g,100g
P115736	小白菊内酯	分析标准品,≥98%	20554-84-1	20mg

*ATM/ATR

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	Ki	EC50
B126286	BEZ235	≥99%	915019-65-7	25mg,100mg,1g	无细胞	p110α	4 nM
						p110γ	5 nM
						p110δ	7 nM
						p110β	75 nM
						mTOR(p70S6K)	6 nM
					3T3TopBP1-ER 细胞	ATR	21 nM
K126884	KU-55933 (ATM Kinase Inhibitor)	≥98%	587871-26-9	5mg,25mg,100mg	无细胞	ATM	12.9 nM	2.2 nM
K127121	KU-60019	≥98%	925701-49-1	5mg,25mg,100mg	无细胞	ATM	6.3 nM
V125220	VE-821	≥98%	1232410-49-9	5mg,25mg,100mg	无细胞	ATR	13 nM	26 nM
W100984	Wortmannin	98%	19545-26-7	5mg,10mg,25mg	无细胞	PI3K	3 nM
						DNA-PK/ATM	16 nM
						DNA-PK/ATM	150 nM
T129646	Torin 2	≥98%	1223001-51-1	5mg,10mg,50mg	p53−/− MEFs细胞系	mTOR	0.25 nM
					PC3细胞系	ATM/ATR/DNA-PK			28 nM
						ATM/ATR/DNA-PK			35 nM
						ATM/ATR/DNA-PK			118 nM
C128014	CP-466722	≥98%	1080622-86-1	5mg,25mg		ATM	410 nM
E125288	ETP-46464	≥99%	1345675-02-6	10mg,50mg		ATR	25 nM
C129735	CGK 733	≥99%	905973-89-9	5mg,10mg,50mg		ATM	200 nM
C129735	CGK 733	≥99%	905973-89-9	5mg,10mg,50mg		ATR	200 nM
A125603	AZ20	≥98%	1233339-22-4	5mg,10mg,50mg	无细胞	ATR	5 nM
S117968	五味子乙素	分析标准品,>98%	61281-37-6	25mg,100mg		ATR	7.25 μM
C129284	磷酸氯喹	≥99%	50-63-5	5g,10g,25g,100g,500g		ATM

*PARP

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	Ki	EC50
O126162	Olaparib (AZD2281, Ku-0059436)	≥98%	763113-22-0	10mg,25mg,100mg,250mg,1g,5g		PARP1	5 nM
O126162	Olaparib (AZD2281, Ku-0059436)	≥98%	763113-22-0	10mg,25mg,100mg,250mg,1g,5g		PARP2	1 nM
V127105	Veliparib	≥99%	912444-00-9	10mg,50mg,250mg	无细胞	PARP1		5.2 nM
V127105	Veliparib	≥99%	912444-00-9	10mg,50mg,250mg	无细胞	PARP2		2.9 nM
R129879	Rucaparib (AG-014699,PF-01367338)	≥99%	459868-92-9	5mg,10mg,50mg		PARP		1.4 nM
B125751	Iniparib (BSI-201)	≥98%	160003-66-7	10mg,50mg,250mg
B127705	BMN 673	≥98%	1207456-01-6	10mg,50mg
A125467	AG14361	≥98%	328543-09-5	5mg,10mg,50mg	无细胞	PARP1		<5 nM
A107207	3-氨基苯甲酰胺	98%	3544-24-9	1g,5g,25g,100g	CHO细胞	PARP	<50 nM
P129886	PJ34 HCl	≥97%	344458-15-7	5mg,25mg,100mg		PARP			20 nM
M127627	MK-4827 (Niraparib)	98%	1038915-60-4	10mg,50mg,100mg		PARP1	3.8 nM
M127627	MK-4827 (Niraparib)	98%	1038915-60-4	10mg,50mg,100mg		PARP2	2.1 nM
U129885	UPF 1069	≥98%	1048371-03-4	10mg,50mg		PARP1	8.0 μM
U129885	UPF 1069	≥98%	1048371-03-4	10mg,50mg		PARP2	0.3 μM
A127274	AZD2461	≥98%	1174043-16-3	5mg,25mg,100mg		PARP
H157172	4-羟基喹唑啉	≥98.0%(HPLC)	491-36-1	5g,25g,100g
B110551	苯甲酰胺	99%	55-21-0	25g,100g,500g,2.5kg		PARP	3.3 μM
B110552	苯甲酰胺	AR,98%	55-21-0	25g,100g,500g		PARP	3.3 μM
B118608	苯甲酰胺	99.5%,升华纯化	55-21-0	5g,25g		PARP	3.3 μM
P138238	吡啶酰胺	≥98.0%(HPLC)	1452-77-3	5g,25g,100g		PARP	95 μM

*DNA/RNA合成

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	Ki	Kd
G120180	盐酸吉西他滨	98%	122111-03-9	10mg,50mg,250mg,1g,5g,25g	PANC1细胞	DNA合成	50 nM
					MIAPaCa2细胞		40 nM
					BxPC3细胞		18 nM
					Capan2细胞		12 nM
P129841	Pemetrexed	≥99%	150399-23-8	50mg,250mg	无细胞	TS		1.3 nM
						DHFR		7.2 nM
						GARFT		65 nM
C110682	卡铂	98%	41575-94-4	100mg,250mg,1g,5g
P124220	喷司他丁	98%(HPLC)	53910-25-1	5mg,25mg
F122998	氟达拉滨	98%	21679-14-1	50mg,250mg,1g,5g
O124003	奥沙利铂	99%	61825-94-3	25mg,100mg,500mg
C127663	CX-5461	≥98%	1138549-36-6	5mg,25mg,100mg	HCT-116细胞	rRNA合成	142 nM
					A375细胞
					MIA PaCa-2细胞
F100149	5-氟尿嘧啶	99%	51-21-8	1g,5g,25g,100g,500g
C124969	Capecitabine	≥99%	154361-50-9	250mg,1g,5g,25g
F122999	单磷酸氟达拉滨	99%	75607-67-9	25mg,100mg,500mg
C126447	Cidofovir	≥98%	113852-37-2	25mg,100mg
C111218	阿糖胞苷	98%	147-94-4	1g,5g,25g,100g
G127944	Gemcitabine	≥99%	95058-81-4	50mg,100mg,250mg,1g,5g,25g
D129529	Daptomycin	≥98%	103060-53-3	10mg,50mg,100mg,1g
C129833	Cladribine	≥98%	4291-63-8	10mg,50mg,100mg,250mg,25g	U266, RPMI8226MM1.S细胞	腺苷脱氨酶	2.43 μM
					U266, RPMI8226MM1.S细胞		0.75 μM
					U266, RPMI8226MM1.S细胞		0.18 μM
R129835	Raltitrexed	≥98%	112887-68-0	10mg,50mg,100mg
C102625	克罗拉滨	99%	123318-82-1	5mg,20mg,25mg,100mg,500mg		Ribonucleotide reductase	65 nM
I123381	异环磷酰胺	药用级	3778-73-2	50mg,250mg,1g,5g
I123242	异环磷酰胺	98%	3778-73-2	1g,5g,25g
N129848	NSC 207895	≥99%	58131-57-0	1mg,5mg,10mg,50mg		MDMX	2.5 μM
D129847	Dacarbazine	≥98%	4342-03-4	1g,5g,25g
H106352	羟基脲	98%	127-07-1	1g,5g,25g,100g
F110732	5-氟-2'-脱氧尿苷	99%	50-91-9	100mg,250mg,500mg,1g,5g,25g
M126858	6-巯基嘌呤 (6-MP)	≥99%	50-44-2	50mg,250mg,1g,5g,25g,100g
M129842	Mizoribine	≥98%	50924-49-7	10mg,50mg,100mg,250mg
M104154	甲萘醌	98%	58-27-5	5g,25g,100g,250g,500g
C153374	卡莫氟	>98.0%(HPLC)	61422-45-5	5g,25g
F129607	Fidaxomicin	≥99%	873857-62-6	5mg,50mg,100mg,250mg
M109874	甲硝唑	99%	443-48-1	5g,25g,100g,500g
M109873	甲硝唑	分析标准品,>99.8%(GC)	443-48-1	5g,25g,100g
T129222	Trifluridine	≥98%	70-00-8	50mg,100mg,250mg,1g
R126176	Rifaximin	≥97%	80621-81-4	250mg,1g,5g,25g
P129854	Procarbazine HCl	≥98%	366-70-1	50mg,250mg,1g
A170956	阿糖腺苷	99%	5536-17-4	1g,5g,25g
R105455	Rifampicin	97%	13292-46-1	250mg,1g,5g,25g,100g
C129367	Clevudine	≥99%	163252-36-6	10mg,50mg
M113888	氮芥盐酸盐	98%	55-86-7	5g,25g
T125377	FT-207 (NSC 148958)	≥98% (HPLC)	17902-23-7	5g,25g,100g
N129652	Nedaplatin	≥99%	95734-82-0	10mg,50mg,250mg		DNA合成	94 μM
M102403	Mupirocin	95%	12650-69-0	25mg,50mg,100mg,250mg,1g
E106318	维生素D2	98%	50-14-6	1g,5g,25g		pol A	123 mM
A118559	1-(1-金刚烷基)乙基胺盐酸盐	99%	1501-84-4	1g,5g,25g,100g
M111820	6-巯基嘌呤一水合物	98%	6112-76-1	1g,5g,25g
M111819	6-巯基嘌呤一水合物	99.50%	6112-76-1	1g,5g,25g
P101249	补骨脂素	98%	66-97-7	25mg,100mg,500mg
P101248	补骨脂素	分析标准品,≥98%	66-97-7	20mg
C103233	盐酸环胞苷	98%	10212-25-6	1g,5g,25g
N124837	7-硝基吲哚-2-羧酸	≥97%(HPLC)	6960-45-8	250mg,1g,5g		APE1	~3 μM
N159515	盐酸尼莫司汀	>98.0%(HPLC)(T)	55661-38-6	250mg,1g
V119467	阿糖腺苷一水合物	99%	24356-66-9	1g,5g
P127282	Sofosbuvir	≥99%	1190307-88-0	5mg,25mg,100mg
C132260	Carmustine	≥98%	154-93-8	25mg,100mg,500mg,25g
Y127218	YK-4-279	≥98%	1037184-44-3	10mg,50mg,100mg
M101153	佛手苷内酯	>98.0%(GC)	484-20-8	50mg,250mg,1g,5g
M101152	佛手苷内酯	分析标准品,>98.0%(GC)	484-20-8	20mg
M158439	5-甲氧基黄酮	>98.0%(GC)	42079-78-7	200mg,1g,2.5g,5g
O131612	噁喹酸	98%	14698-29-4	5g,25g
O114347	噁喹酸	分析标准品	14698-29-4	250mg
C139195	盐酸阿糖胞苷	≥99%	69-74-9	250mg,1g,5g,25g
B139600	灭瘟素 S 盐酸盐	≥96%	3513-03-9	10mg,25mg,100mg
C154015	氯氨布西	>98.0%	305-03-3	50mg,200mg,1g,5g
T102749	异氰尿酸三缩水甘油酯	98%	2451-62-9	25g,100g,250g,500g
F129839	Flupirtine maleate	≥99%	75507-68-5	10mg,25mg,100mg,1g
P128017	Pyridostatin	-	1085412-37-8	5mg,10mg,25mg,50mg,100mg	无细胞	G-quadruplexe			490 nM
B107423	硫酸博来霉素	1.5-2.0 units/mg	9041-93-4	5mg,25mg,100mg
P166509	嘌呤	98%	120-73-0	1g,5g
T127425	Temozolomide	≥98% (HPLC)	85622-93-1	250mg,500mg,1g,5g,25g,100g
B124707	Bendamustine HCl	≥98%(HPLC)	3543-75-7	100mg,500mg
L123247	洛莫司汀	98%	13010-47-4	50mg,250mg,1g
B110731	5-溴-2'-脱氧尿苷(BUdR)	99%	59-14-3	250mg,1g,5g,25g
G104274	鸟嘌呤	99%	73-40-5	5g,25g,100g,250g,500g
D100363	2’-脱氧尿苷	99%	951-78-0	1g,5g,25g
A129567	8-氮杂鸟嘌呤	≥95%	134-58-7	1g,5g,25g
T104771	β-胸苷	99%	50-89-5	1g,5g,25g,100g
A108805	腺嘌呤	≥99.5%(HPLC)	73-24-5	5g,25g,100g,250g
A108804	腺嘌呤	98%	73-24-5	25g,100g,500g,2.5kg
C101487	胞苷-5'-三磷酸二钠盐(CTP)	95%	36051-68-0	1g,5g,25g
C101008	胞苷-5'磷酸(5'-CMP)	99%	63-37-6	1g,5g
C100916	胞苷-5'磷酸	98%	63-37-6	1g,5g,25g
U100365	5’-三磷酸尿苷三钠(UTP)	99%	19817-92-6	25mg,100mg,500mg,1g,5g
N191760	N6-甲基腺苷	98%	1867-73-8	250mg,1g
U108811	尿嘧啶核苷	99%,用于细胞培养	58-96-8	5g,25g
U108810	尿嘧啶核苷	99%	58-96-8	5g,25g,100g
T108392	胸腺嘧啶	99%,用于细胞培养	65-71-4	5g,25g
T108391	胸腺嘧啶	99%	65-71-4	5g,25g,100g,500g

*Sirtuin

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	EC50
E129892	EX 527 (Selisistat)	≥98%	49843-98-3	5mg,10mg,50mg	无细胞	SIRT1	38 nM
N108087	烟酰胺	用于细胞和昆虫细胞培养,≥99.5% (HPLC)	98-92-0	100g,500g
N108086	烟酰胺	≥99.5%(HPLC)	98-92-0	100g,250g,500g
N105043	烟酰胺	分析标准品,≥99.8%	98-92-0	1g
N105042	烟酰胺	99%	98-92-0	100g,500g
S129890	SRT1720	≥98%	1001645-58-4	5mg,10mg,50mg	无细胞	SIRT1		0.16 μM
S140425	丹酚酸 B	分析标准品	121521-90-2	10mg
S123658	丹酚酸 B	≥94%(HPLC)	121521-90-2	5mg,25mg
Q111274	槲皮素	95%	117-39-5	1g,10g,50g,250g		PI3Kγ	2.4 μM
Q111273	槲皮素	分析标准品,≥98.5%	117-39-5	20mg		PI3Kδ	3.0 μM
Q118458	槲皮素,二水	分析标准品,≥98%(HPLC)	6151-25-3	20mg
Q104838	槲皮素,二水	97%	6151-25-3	5g,10g,25g,50g,100g,250g,500g

*Topoisomerase

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	Ki
D107159	盐酸阿霉素	98%	25316-40-9	25mg,100mg,250mg,500mg,1g,5g		Topo II
E121713	Etoposide	98%	33419-42-0	100mg,250mg,500mg,1g,5g		Topo II
C111282	(S)-(+)-喜树碱	97%	7689-03-4	100mg,250mg,1g,5g		Topo I	0.68 μM
C111281	(S)-(+)-喜树碱	分析标准品,≥98%	7689-03-4	20mg		Topo I	0.68 μM
T294611	盐酸拓扑替康	98%	119413-54-6	50mg,250mg	无细胞	Topo I (MCF-7 Luc细胞)	13 nM
T294611	盐酸拓扑替康	98%	119413-54-6	50mg,250mg	无细胞	Topo I (DU-145 Luc细胞)	2 nM
T103153	盐酸拓扑替康	分析标准品,≥99%(HPLC)	119413-54-6	10mg,50mg	无细胞	Topo I (MCF-7 Luc细胞)	13 nM
T103153	盐酸拓扑替康	分析标准品,≥99%(HPLC)	119413-54-6	10mg,50mg	无细胞	Topo I (DU-145 Luc细胞)	2 nM
I129863	Idarubicin HCl	≥98%	57852-57-0	1mg,5mg,10mg,50mg	无细胞	Topo II (MCF-7 cells)	3.3 ng/mL
R139432	鲁比特康	≥98.0%(HPLC)	91421-42-0	25mg,100mg
E122334	盐酸表柔比星	≥98% (HPLC)	56390-09-1	5mg,25mg
M129460	Mitoxantrone dihydrochloride	≥97%	70476-82-3	10mg,50mg,250mg,1g
D122335	盐酸佐柔比星	>90%	23541-50-6	10mg,50mg,250mg	无细胞	DNA合成		0.02 μM
M129861	Moxifloxacin HCl	≥99%	186826-86-8	50mg,100mg,500mg,1g,5g,25g
I129860	Irinotecan HCl Trihydrate	≥98%	136572-09-3	100mg,250mg,500mg,1g
E110128	7-乙基-10羟基喜树碱	98%	86639-52-3	100mg,500mg,1g,5g		Topo I
A126932	Amonafide	≥98%	69408-81-7	10mg,50mg,250mg
T125922	Teniposide	≥98%	29767-20-2	20mg,25mg,100mg
G129827	Gatifloxacin	≥98%	112811-59-3	1g,5g,10g,25g
D129340	Dexrazoxane HCl (ICRF-187, ADR-529)	≥99%	149003-01-0	10mg,50mg,250mg		Topo II
G106672	金雀异黄酮	分析标准品,≥98%	446-72-0	20mg,1g,5g	NIH-3T3细胞	EGFR	12μM
G106672	金雀异黄酮	分析标准品,≥98%	446-72-0	20mg,1g,5g	NIH-3T3细胞	topo II	19 μM
G106673	金雀异黄酮	97%	446-72-0	100mg,500mg,1g,5g,25g	NIH-3T3细胞	EGFR	12μM
G106673	金雀异黄酮	97%	446-72-0	100mg,500mg,1g,5g,25g	NIH-3T3细胞	topo II	19 μM
L157745	Levofloxacin	>98.0%(HPLC)	100986-85-4	5g,25g,100g,500g
P129867	Pirarubicin	≥97%	72496-41-4	10mg,50mg		Topo II
M139937	马波沙星	98%	115550-35-1	1g,5g,25g
M114260	马波沙星	分析标准品	115550-35-1	100mg
C129896	Ciprofloxacin	≥98%	85721-33-1	5g,25g,100g
N129248	Novobiocin Sodium	≥95%	1476-53-5	50mg,100mg,500mg,1g,5g
E194832	依诺沙星	98%	74011-58-8	1g,5g,25g
O102014	Ofloxacin	98%	82419-36-1	1g,5g,25g,100g
O102012	Ofloxacin	分析标准品,≥99.0%(HPLC)	82419-36-1	100mg
N114262	诺氟沙星	98%	70458-96-7	1g,5g,25g,100g,500g
N114261	诺氟沙星	分析标准品	70458-96-7	100mg
E102710	鞣花酸	96%	476-66-4	1g,5g,25g,100g
N104920	萘啶酮酸	98%	389-08-2	5g,25g,100g
C129430	Clinafloxacin	≥95%	105956-97-6	50mg,250mg,1g
P102019	培氟沙星	99%	149676-40-4	5g,25g,100g
P102018	培氟沙星	分析标准品	149676-40-4	100mg		Topo II
A107930	盐酸胺苯吖啶	≥98% (HPLC)	54301-15-4	25mg,100mg
B129359	Balofloxacin	98%	127294-70-6	100mg,500mg
H107536	5-硝基-8-羟基喹啉	97%	4008-48-4	5g,25g,100g
H196266	(S)-10-羟基喜树碱	98%	19685-09-7	500mg,1g,5g,25g
H109791	(S)-10-羟基喜树碱	分析标准品,98%	19685-09-7	25mg,100mg
T166659	Topotecan hydrochloride hydrate	98% (HPLC and enzymatic)	123948-87-8	10mg,20mg,50mg
B123958	白桦脂酸	97%	472-15-1	100mg,1g,5g
B101534	白桦脂酸	分析标准品,>98%	472-15-1	20mg
E134852	7-乙基喜树碱	≥96.0%(HPLC)	78287-27-1	50mg,250mg,1g,5g,25g
F131683	氟甲喹	≥98.0%	42835-25-6	1g,5g,25g,100g
F114353	氟甲喹	分析标准品	42835-25-6	250mg		Topo II	15 μM