槲皮素

非选择性PI 3-激酶抑制剂

规格或纯度: 95%

CAS编号: 117-39-5
分子式: C₁₅H₁₀O₇
分子量: 302.24
Beilstein号: 317313
EC号: 204-187-1
MDL号: MFCD00006828
PubChem编号: 5280343

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货号 (SKU)	包装规格	是否现货
Q111274-1g	1g	现货
Q111274-10g	10g	现货
Q111274-50g	50g	现货
Q111274-250g	250g	现货

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基本描述

别名	栎精\|槲皮黄素\|3,3',4',5,6-五羟基黄酮
英文别名	quercetin\|117-39-5\|Meletin\|Sophoretin\|Quercetine\|Xanthaurine\|Quercetol\|Quertine\|Quercitin\|2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one\|3,3',4',5,7-Pentahydroxyflavone\|Cyanidelonon 1522\|Flavin meletin\|3,5,7,3',4'-Pentahydroxyflavone\|Quertin\|T-
规格或纯度	95%
英文名称	Quercetin
生化机理	抗肿瘤剂；诱导细胞凋亡并抑制热激蛋白的合成。抑制许多酶系统，包括酪氨酸蛋白激酶，磷脂酶A2，磷酸二酯酶，线粒体ATPase，PI 3-激酶和蛋白激酶C。还可以激活Ca2 +和K +通道并在雌激素（GPER）受体上起激动剂的作用。通过与血凝素的相互作用阻止甲型流感病毒进入细胞。抑制SARS-CoV 3CLpro（IC50 = 73μM）。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	槲皮素是一种抗氧化剂，可逆转2型糖尿病患者高血糖和高血糖血清的免疫抑制作用。它已被用作欧洲黑蜂的一种解毒植物化学物质。它被用作DPPH(2,2-二苯基-1-苦肼)自由基清除实验中的阳性对照。它还可用于制作总黄酮含量测定的校准曲线。 Quercetin, one of the main flavonoids that exists in galangal (Zingiberaceae), is a hydroxylated flavanoid that has been shown to cause potent reversible inhibition of fatty-acid synthase. It possesses potential antiinflammatory properties. Quercetin also inhibits Trk (tyrosine protein kinase), phospholipase A2, PDE (phosphodiesterases), mitochondrial ATPase, PI 3-kinase and PKC (protein kinase C). It has been reported that the competitive inhibition of FASN by quercetin leads to apoptotic cell death which results in inhibition of cell proliferation. Quercetin also behaves as a GPR30 activator and calcium channel protein inhibitor. A PI 3-kinase inhibitor, GPR30 activator, and apoptosis inducer.

名称和标识符

EC号	204-187-1
IUPAC Name	2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
INCHI	InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
InChi Key	REFJWTPEDVJJIY-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
Isomeric SMILES	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
WGK Germany	3
RTECS	LK8750000
PubChem CID	5280343
UN Number	2811
Packing Group	I
分子量	302.24
Beilstein号	317313

数据库链接

Wikipedia	Quercetin
DrugBank Ligand	DB04216
CAS Registry No.	117-39-5
ChEBI	CHEBI:16243
PubChem CID	5280343
BitterDB Ligand	444
ChEMBL Ligand	CHEMBL50
RCSB PDB Ligand	QUE
DrugCentral Ligand	3514

化学和物理性质

溶解性	溶于DMSO, 最高浓度 (mg/mL): None, 最高浓度(mM): 100
密度	1.799
熔点	314-317°C

安全和危险性（GHS）

象形图	Toxic
信号词	Danger
危险声明	H301: Toxic if swallowed
预防措施声明	P301+P310,P405,P501,P264,P270
WGK Germany	3
RTECS	LK8750000
Class	6.1
个人防护装备	Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

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参考文献

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槲皮素

库存信息

库存信息

库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全和危险性（GHS）

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质检报告(COA)

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