概述规格名称和识别符技术文档高级数据系统学分类三维结构质检证书（CoA,COO,BSE/TSE 和分析图谱) 化学和物理性质安全和危险性（GHS）此产品的引用文献技术文档和文章引用文献溶液计算器

🧪

为什么选择此级别

提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

🌡

储存与运输

室温。常规运输。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 79 篇同行评审文献引用。

概述

3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. A multi-use inhibitor that protects cerebellar granule cells from apoptosis.

3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation.
A multi-use inhibitor that protects cerebellar granule cells from apoptosis.

规格

别名

6-氨基-3-甲基嘌呤

英文别名

规格或纯度

≥98%

英文名称

3-Methyladenine

生化机理

选择性PI3K抑制剂。抑制自噬的初始阶段。阻止自噬体形成。增强细胞凋亡。抑制蛋白质降解（IC 50 = 5 mM，大鼠肝细胞）。

储存条件

室温

运输条件

常规运输

备注

如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

纯度

≥98%

名称和识别符

PubChem SID

508809037

分子类型

小分子

IUPAC Name

3-methyl-7H-purin-6-imine

INCHI

1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3,7H,1H3,(H,8,9)

InChi Key

ZPBYVFQJHWLTFB-UHFFFAOYSA-N

Smiles

CN1C=NC(=N)C2=C1N=CN2

Isomeric SMILES

CN1C=NC(=N)C2=C1N=CN2

分子量

149.15

Reaxy-Rn

512745

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=512745&ln=

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

系统学分类

分类树（Taxonomy Tree）

界（kingdom) 有机化合物
- 超类（Superclass) 有机杂环化合物
  - 类（Class) 咪唑并嘧啶类
    - 亚类（Subclass）嘌呤和嘌呤衍生物

界（kingdom)	有机化合物
超类（Superclass)	有机杂环化合物
类（Class)	咪唑并嘧啶类
亚类（Subclass）	嘌呤和嘌呤衍生物
中间层级节点（Intermediate Tree Nodes）	暂无
直接上位类(Direct Parent)	嘌呤和嘌呤衍生物
其他上位类（Alternative Parents）	嘧啶和嘧啶衍生物咪唑类杂芳族化合物氮杂环化合物有机光子化合物有机氮化合物碳氢化合物衍生物
分子骨架（Molecular Framework)	芳香族杂多环化合物
取代基（Substituents）	芳香族杂多环化合物 - 氮杂环 - 吡唑 - 杂芳香族化合物 - 烃衍生物 - 咪唑 - 有机硝基化合物 - 有机氮化合物 - 有机氮化合物 - 鸟苷酸 - 嘧啶
描述（Description）	该化合物属于嘌呤及其衍生物类有机化合物。这类芳香杂环化合物含有嘌呤结构单元，由嘧啶环与咪唑环共轭形成。
外部描述符（External Descriptors）	暂无

三维结构

交互式化学结构模型

球棍
棍棒
线框模型
空间填充
显示氢气
动画

化学和物理性质

溶解性

Soluble in DMSO (10 mg/ml), water (5 mg/ml), DMF (10 mg/ml), 95% ethanol, and 1N NaOH heating (30 mg/ml).

熔点

300 °C(dec.)

分子量

149.150 g/mol

XLogP3

-0.200

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

149.07 Da

单同位素质量Monoisotopic Mass

149.07 Da

拓扑极表面积Topological Polar Surface Area

68.100 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

211.000

同位素原子数Isotope Atom Count

定义的原子立体中心计数Defined Atom Stereocenter Count

未定义的原子立体中心计数Undefined Atom Stereocenter Count

定义的键立体中心计数Defined Bond Stereocenter Count

未定义的键立体中心计数Undefined Bond Stereocenter Count

所有立体化学键的总数The total count of all stereochemical bonds

共价键合单元计数Covalently-Bonded Unit Count

安全和危险性（GHS）

象形图

GHS07

信号词

警告

危险声明

H302: 吞食有害

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

预防措施声明

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P330: 漱口

P302+P352: 如皮肤沾染：用水充分清洗。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P301+P317: 如果被吞咽：请寻求医疗帮助。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

WGK Germany

RTECS

AU6520000

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到24个结果

批号(Lot Number)	证书类型	货号
E2628062	分析证书	M129496
A2115245	分析证书	M129496
J2210223	分析证书	M129496
J2210582	分析证书	M129496
J2210224	分析证书	M129496
B2419168	分析证书	M129496
D2620017	分析证书	M129496
K2519028	分析证书	M129496
J2528175	分析证书	M129496
F2002140	分析证书	M129496
L2301101	分析证书	M129496
J2317030	分析证书	M129496
G2507028	分析证书	M129496
G2429017	分析证书	M129496
J2210581	分析证书	M129496
L2110154	分析证书	M129496
L2110129	分析证书	M129496
L2110155	分析证书	M129496
L2110156	分析证书	M129496
I2126352	分析证书	M129496
C2314277	分析证书	M129496
A2115244	分析证书	M129496
J2210221	分析证书	M129496
G2311032	分析证书	M129496

显示更多⌵

技术文档和文章

PI3K-Akt-mTORC信号通路

目录：技术文章

探索主题:

PI3K-Akt-mTORC信号通路

PI3K-Akt-mTORC Signaling

目录：技术文章

探索主题:

PI3K-Akt-mTORC Signaling

如何判断一个蛋白是否适合靶向降解：从降解通路、分子设计到机制验证

目录：技术文章

探索主题:

蛋白质靶向蛋白降解靶向降解

How to Determine Whether a Protein Is Suitable for Targeted Degradation: From Degradation Pathway and Molecular Design to Mechanism Validation

目录：技术文章

探索主题:

protein Targeted protein degradation Targeted degradation

细胞自噬检测方法的技术路线与结果判读

目录：技术文章

探索主题:

Western blot 溶酶体功能细胞自噬自噬通量 LC3 p62/SQSTM1 Beclin 1 ATG蛋白自噬体自噬溶酶体荧光成像透射电子显微镜线粒体自噬

自噬信号通路与选择性自噬研究

目录：技术文章

探索主题:

自噬自噬通量 LC3 ATG蛋白线粒体自噬 p62 Beclin1 mTOR AMPK 选择性自噬

Autophagy Signaling Pathways and Selective Autophagy Research

目录：技术文章

探索主题:

Autophagy LC3 autophagic flux ATG proteins mitophagy p62 Beclin1 mTOR AMPK selective autophagy

从代谢流到蛋白质降解：代谢酶与蛋白质降解系统如何共同调控细胞命运

目录：技术文章

探索主题:

蛋白酶代谢酶

From Metabolic Flux to Protein Degradation: How Metabolic Enzymes and Protein Degradation Systems Jointly Regulate Cell Fate

目录：技术文章

探索主题:

proteases metabolic enzymes Cell fate

衰老相关营养感知、炎症与稳态信号通路的调控机制

目录：技术文章

探索主题:

自噬 NF-κB 衰老 mTOR AMPK 衰老相关分泌表型 NAD⁺ IIS IGF-1 Sirtuins

Regulatory Mechanisms of Aging-Related Nutrient Sensing, Inflammation, and Homeostatic Signaling Pathways

目录：技术文章

探索主题:

Autophagy NF-κB Aging mTOR AMPK senescence-associated secretory phenotype NAD⁺ IIS IGF-1 Sirtuins

AUTAC还是AUTOTAC？第一代、第二代自噬靶向降解技术的机制差异

目录：技术文章

探索主题:

靶向蛋白降解 LC3 p62 选择性自噬 AUTAC AUTOTAC ATTEC 自噬-溶酶体

AUTAC or AUTOTAC? Mechanistic Differences Between First- and Second-Generation Autophagy-Targeting Degradation Technologies

目录：技术文章

探索主题:

Targeted protein degradation LC3 p62 selective autophagy AUTAC AUTOTAC ATTEC autophagy-lysosome system

自噬的分子机制、选择性降解与疾病调控

目录：技术文章

探索主题:

自噬溶酶体 LC3 线粒体自噬选择性自噬 LAMP2A 巨自噬微自噬分子伴侣介导的自噬

Molecular Mechanisms, Selective Degradation, and Disease Regulation of Autophagy

目录：技术文章

探索主题:

Autophagy Lysosome LC3 mitophagy selective autophagy LAMP2A macroautophagy microautophagy chaperone-mediated autophagy

LYSET：癌细胞求生背后的溶酶体酶转运支点

目录：技术文章

探索主题:

溶酶体肿瘤代谢 LYSET TMEM251 GNPTAB 甘露糖-6-磷酸 M6P 大胞饮

LYSET: The Lysosomal Enzyme Trafficking Hub Behind Cancer Cell Survival

目录：技术文章

探索主题:

Lysosome Tumor Metabolism LYSET TMEM251 GNPTAB M6P mannose-6-phosphate macropinocytosis

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui. (2023) Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:37870273] [10.1021/acs.jafc.3c01244]
2. Le Chen, Hongmei Qiu, Qingqiu Chen, Peng Xiang, Jin Lei, Jun Zhang, Yining Lu, Xianmin Wang, Shengde Wu, Chao Yu, Limei Ma. (2023) N-acetylneuraminic acid modulates SQSTM1/p62 sialyation-mediated ubiquitination degradation contributing to vascular endothelium dysfunction in experimental atherosclerosis mice. IUBMB LIFE, [PMID:37818680] [10.1002/iub.2788]
3. Yiqian Zhang, Qianrui Huang, Qisi Xu, Chengsen Jia, Yong Xia. (2023) Pimavanserin tartrate induces apoptosis and cytoprotective autophagy and synergizes with chemotherapy on triple negative breast cancer. BIOMEDICINE & PHARMACOTHERAPY, [PMID:37832400] [10.1016/j.biopha.2023.115665]
4. Huan Hou, Yaping Yang, Rong Chen, Zhiping Guo. (2023) Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway. TOXICOLOGY IN VITRO, [PMID:37769856] [10.1016/j.tiv.2023.105704]
5. Lihuan Shang, Qi Xie, Conglian Yang, Li Kong, Zhiping Zhang. (2023) Extracellular Vesicles Facilitate the Transportation of Nanoparticles within and between Cells for Enhanced Tumor Therapy. ACS Applied Materials & Interfaces, [PMID:37658814] [10.1021/acsami.3c10237]
6. Minghui Cai, Haijuan Sun, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu. (2023) Resveratrol Protects Rat Ovarian Luteinized Granulosa Cells from H2O2-Induced Dysfunction by Activating Autophagy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (13): (10914). [PMID:37446088] [10.3390/ijms241310914]
7. Hui Wang, Jianfei Li, Jingbo Xu, Yunfeng Hu, Yifan Zuo, Jin Li. (2023) Enzyme/pH Dual-Responsive Size-Shrinkable Nanocomposites for Tumor Penetration and Enhanced Multimodal Cancer Therapy. ACS Applied Nano Materials, [10.1021/acsanm.3c01850]
8. Yanli Zhang, Yulin Zhang, Ye Lei, Junrong Wu, Yiyuan Kang, Shuo Zheng, Longquan Shao. (2023) MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy. JOURNAL OF HAZARDOUS MATERIALS, [PMID:37315416] [10.1016/j.jhazmat.2023.131750]
9. Jing Zhu, Zhenyao Li, Fengli Yin, Xiaoting Yu, Yuanfan Lu, Tong Zhou, Fanghua Gong, Zhangye Xu. (2023) Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway. Frontiers in Pharmacology, [PMID:37153783] [10.3389/fphar.2023.1143096]
10. Lina Cai, Mingqing Dang, Yawen Yang, Ruoxin Mei, Fan Li, Xiaorong Tao, Peter Palukaitis, Randy Beckett, W. Allen Miller, Stewart M. Gray, Yi Xu. (2023) Naturally occurring substitution of an amino acid in a plant virus gene-silencing suppressor enhances viral adaptation to increasing thermal stress. PLoS Pathogens, 19 (4): (e1011301). [PMID:37011127] [10.1371/journal.ppat.1011301]
11. Xuehua Long, Huiqi Wang, Jianqin Yan, Yifei Li, Xue Dong, Sijia Tian, Yong Sun, Kui Luo, Bin He, Yan Liang. (2023) Tailor-Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy. Small, [PMID:36932938] [10.1002/smll.202207898]
12. Jiahong Guo, Wenji Huang, Xin Zhao, Ning Ji, Kangyong Chen, Yanjie Shi, Jianhua Feng, Jun Zou, Junya Wang. (2023) The expanded ISG12 family in zebrafish: ISG12.1 suppresses virus replication via targeting viral phosphoprotein. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, [PMID:36822549] [10.1016/j.dci.2023.104672]
13. Hao Tang, Shida Zhu, Kai Chen, Shujie Yuan, Junzu Hu, Hongkai Wang. (2023) IL-17A regulates autophagy and promotes osteoclast differentiation through the ERK/mTOR/Beclin1 pathway. PLoS One, 18 (2): (e0281845). [PMID:36795736] [10.1371/journal.pone.0281845]
14. Shao-Yi Chen, Lin-Ping Zhao, Zu-Xiao Chen, Chu-Yu Huang, Ren-Jiang Kong, Yu-Qing Wang, Da-Wei Zhang, Shi-Ying Li, Hui-Hui Ti, Hong Cheng. (2023) Self-delivery biomedicine for enhanced photodynamic therapy by feedback promotion of tumor autophagy. Acta Biomaterialia, [PMID:36603734] [10.1016/j.actbio.2022.12.059]
15. Xu Chi, Jiang Shuyun, Ma Xingyu, Jiang Zeyong, Pan Youguang, Li Xiang, Zhang Liying, Zhou Hao, Chen Shen, Xing Xiumei, Chen Liping, Fu Wenfan, Wang Qing, Chen Wen, Li Daochuan. (2022) CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy. ARCHIVES OF TOXICOLOGY, 97 (2): (441-456). [PMID:36336710] [10.1007/s00204-022-03404-0]
16. Haitao Wang, Jianhua Zhang, Haoqiu Liu, Man Wang, Yan Dong, Yijun Zhou, Sek-Man Wong, Kai Xu, Qiufang Xu. (2022) A plant virus hijacks phosphatidylinositol-3,5-bisphosphate to escape autophagic degradation in its insect vector. Autophagy, [PMID:36093594] [10.1080/15548627.2022.2116676]
17. Shangmin Yu, Shan Liu, Ning Wang, Di Yu, Meng Qin, Ji Wu, Qingxiang Guan. (2021) Novel insights into antidepressant mechanism of Kai Xin San formula: Inhibiting NLRP3 inflammasome activation by promoting autophagy. PHYTOMEDICINE, [PMID:34735906] [10.1016/j.phymed.2021.153792]
18. Xiaodi Gong, Xin Pu, Jing Wang, Linlin Yang, Yunxia Cui, Lijuan Li, Xiao Sun, Jichang Liu, Jingfeng Bai, Yudong Wang. (2021) Enhancing of Nanocatalyst-Driven Chemodynaminc Therapy for Endometrial Cancer Cells Through Inhibition of PINK1/Parkin-Mediated Mitophagy. International Journal of Nanomedicine, [PMID:34616150] [10.2147/IJN.S329341]
19. Yi-hua Zhou, Yu-zhi Tang, Liang-yun Guo, Li-li Zheng, Dan Zhang, Can-ying Yang, Wei Wang. (2021) Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway. MICROVASCULAR RESEARCH, [PMID:34520772] [10.1016/j.mvr.2021.104252]
20. Bei Sun, Hao Ou, Fei Ren, Yujiao Guan, Ye Huan, Hongwei Cai. (2021) Propofol Protects against Cerebral Ischemia/Reperfusion Injury by Down-Regulating Long Noncoding RNA SNHG14. ACS Chemical Neuroscience, [PMID:34369750] [10.1021/acschemneuro.1c00059]
21. Dandan Zheng, Jinglong Wang, Genju Li, Lulu An, Ying Qu, Qinxiu Zhang, Wenhui Ye, Xin Zhao, Zhongxi Zhao. (2021) S-Allylmercapto-N-acetylcysteine ameliorates elastase-induced chronic obstructive pulmonary disease in mice via regulating autophagy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:34044325] [10.1016/j.bbrc.2021.05.047]
22. Qiuli Wang, Dong Liang, Peng Shen, Yang Yu, Yuan Yan, Wei You. (2021) Hsa_circ_0092276 promotes doxorubicin resistance in breast cancer cells by regulating autophagy via miR-348/ATG7 axis. Translational Oncology, [PMID:34023560] [10.1016/j.tranon.2021.101045]
23. Zhang Yin, Wang Qinge, Xu Yuping, Sun Jing, Ding Yanbo, Wang Li, Chen Bingfang, Sun Kewen, Chen Jianping. (2021) Mitomycin C Inhibits Esophageal Fibrosis by Regulating Cell Apoptosis and Autophagy via lncRNA-ATB and miR-200b. Frontiers in Molecular Biosciences, [PMID:34079820] [10.3389/fmolb.2021.675757]
24. Yingnan Dai, Yeping Chen, Guoqian Wei, Li Zha, Xueqi Li. (2021) Ivabradine protects rats against myocardial infarction through reinforcing autophagy via inhibiting PI3K/AKT/mTOR/p70S6K pathway. Bioengineered, [PMID:33975512] [10.1080/21655979.2021.1925008]
25. Yu Zhang, Yan Liu, Yinxing Zhou, Ziming Zheng, Wenqi Tang, Mengzi Song, Jinglin Wang, Kaiping Wang. (2021) Lentinan inhibited colon cancer growth by inducing endoplasmic reticulum stress-mediated autophagic cell death and apoptosis. CARBOHYDRATE POLYMERS, [PMID:34119128] [10.1016/j.carbpol.2021.118154]
26. Zang Jiankun, Wu Yousheng, Su Xuanlin, Zhang Tianyuan, Tang Xionglin, Ma Dan, Li Yufeng, Liu Yanfang, Weng Ze’an, Liu Xuanzhuo, Tsang Chi Kwan, Xu Anding, Lu Dan. (2021) Inhibition of PDE1-B by Vinpocetine Regulates Microglial Exosomes and Polarization Through Enhancing Autophagic Flux for Neuroprotection Against Ischemic Stroke. Frontiers in Cell and Developmental Biology, [PMID:33614626] [10.3389/fcell.2020.616590]
27. Changrong Wang, Xiaoguang Shi, Huijuan Song, Chuangnian Zhang, Xiaoli Wang, Pingsheng Huang, Anjie Dong, Yumin Zhang, Deling Kong, Weiwei Wang. (2020) Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma. BIOMATERIALS, [PMID:33278683] [10.1016/j.biomaterials.2020.120579]
28. He Bingnan, Wang Xia, Jin Xini, Xue Zimeng, Zhu Jianbo, Wang Caiyun, Jin Yuanxiang, Fu Zhengwei. (2020) β-Cypermethrin promotes the adipogenesis of 3T3-L1 cells via inducing autophagy and shaping an adipogenesis-friendly microenvironment. ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 52 (8): (821-831). [PMID:32637997] [10.1093/abbs/gmaa049]
29. Guo Xiao, Zhang Yongtao, Lu Changhong, Qu Fengxia, Jiang Xianyan. (2020) Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 84 (4): (714-724). [PMID:31797747] [10.1080/09168451.2019.1685369]
30. Sun Xiaowei, Wang Dongyan, Zhang Tingting, Lu Xuejian, Duan Fangfang, Ju Lili, Zhuang Xiaotong, Jiang Xicheng. (2020) Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway. Frontiers in Pharmacology, [PMID:32153404] [10.3389/fphar.2020.00084]
31. Peng Cao, Yu Zhang, Zi Huang, Mitchell A. Sullivan, Zihao He, Jinglin Wang, Zehong Chen, Huiping Hu, Kaiping Wang. (2019) The Preventative Effects of Procyanidin on Binge Ethanol-Induced Lipid Accumulation and ROS Overproduction via the Promotion of Hepatic Autophagy. MOLECULAR NUTRITION & FOOD RESEARCH, 63 (18): (1801255). [PMID:31336037] [10.1002/mnfr.201801255]
32. Bingnan He, Xia Wang, Jianbo Zhu, Baida Kong, Lai Wei, Yuanxiang Jin, Zhengwei Fu. (2019) Autophagy protects murine macrophages from β-cypermethrin-induced mitochondrial dysfunction and cytotoxicity via the reduction of oxidation stress. ENVIRONMENTAL POLLUTION, [PMID:31026688] [10.1016/j.envpol.2019.04.044]
33. Ting Wang, Jinhui Hu, Hao Luo, Huiyang Li, Jiahong Zhou, Lin Zhou, Shaohua Wei. (2018) Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression. Small, 14 (38): (1802337). [PMID:30152186] [10.1002/smll.201802337]
34. Xiaojia Shi, Tao Zhang, Hongxiang Lou, Huina Song, Changhao Li, Peihong Fan. (2020) Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:32996316] [10.1021/acs.jmedchem.0c00881]
35. Wu Xinyang, Chen Shuting, Zhang Zixin, Zhou Weixin, Sun Ting, Ning Kang, Xu Min, Ke Xubo, Xu Pei. (2024) A viral small interfering RNA-host plant mRNA pathway modulates virus-induced drought tolerance by enhancing autophagy. PLANT CELL, [PMID:38801738] [10.1093/plcell/koae158]
36. Wentao Lin, Yong Xia, Anqi He, Shuang Chen, Jie Zhang. (2024) Antipsychotic Zuclopenthixol Inhibits Melanoma Growth and Brain Metastasis by Inducing Apoptosis and Cell Cycle Arrest. Frontiers in Bioscience-Landmark, 29 (4): (132). [PMID:38682202] [10.31083/j.fbl2904132]
37. Yanwei Zhang, Jing Cen, Haixia Wu, Wa Gao, Zhiying Jia, Mikolaj Adamek, Jun Zou. (2024) Autophagy mediated degradation of MITA/TBK1/IRF3 by a hnRNP family member attenuates interferon production in fish. FISH & SHELLFISH IMMUNOLOGY, [PMID:38642725] [10.1016/j.fsi.2024.109563]
38. Jia Song, Jinyu Qiao, Mingxue Chen, Jiahui Li, Jixia Wang, Dayong Yu, Huachuan Zheng, Liying Shi. (2025) Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathway. PeerJ, [PMID:40183046] [10.7717/peerj.19085]
39. Zhang Bu-chun, Zhu Wen-ya, Wang Sheng-nan, Zhu Meng-meng, Ma Hui, Dong Liang, Yang Xiao-xiao, Ma Chuan-rui, Ma Li-kun, Chen Yuan-li. (2024) Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy. ACTA PHARMACOLOGICA SINICA, [PMID:39663419] [10.1038/s41401-024-01438-x]
40. Hai-Ying Tian, Dao-Jiang Yu, Teng Xie, Meng-Xia Xu, Yu-Hao Wang, Xi-Lu Sun, Xin-Meng Zhou, Ying-Xuan Han, Qing-Qing Liao, Yu-Jie Zhao, Juan Liao, Mohamed El-Kassas, Xiao-Dong Sun, Yuan-Yuan Zhang. (2025) Cordycepin alleviates metabolic dysfunction-associated liver disease by restoring mitochondrial homeostasis and reducing oxidative stress via Parkin-mediated mitophagy. BIOCHEMICAL PHARMACOLOGY, [PMID:39793718] [10.1016/j.bcp.2025.116750]
41. Chunmei Ma, Qicheng Zhang, Yan Wang, Dihua Li, Huiying Zhang, Qiang Jia, Wei Zheng, Jian Tan, Ke Xu, Lei Yang, Zhaowei Meng. (2025) Effect of Benzyl Isothiocyanate on Anaplastic Thyroid Cancer Evaluated by Network Pharmacology Combined with Experiments. ACS Omega, [PMID:40160743] [10.1021/acsomega.4c08388]
42. Jingzhi WANG, Zhongyu HUANG, Yiwen LI, Qian LI, Xi LI, Li CHEN. (2024) Electroacupuncture improves cognitive function in high-fat diet/streptozocin-induced type 2 diabetic mice by inhibiting autophagy-related ferroptosis. EXPERIMENTAL ANIMALS, [PMID:39647901] [10.1538/expanim.24-0072]
43. Zhang Yanwei, Jia Zhao, Yuan Gaoliang, Chen Kangyong, Cen Jing, Wang Junya, Feng Hao, Adamek Mikolaj, Zou Jun. (2025) HnRNPC triggers the degradation of MITA to suppress the interferon-mediated antiviral response. VETERINARY RESEARCH, 56 (1): (1-17). [PMID:39994817] [10.1186/s13567-025-01463-6]
44. Li Fan, Lijuan Zhao, Yangbo Zhu, Lin Li, Xueping Yang, Ping Ma, Jian Liu, Qingwei Zhao, Xiaobo Li. (2024) Hydroxytyrosol ameliorates stress–induced liver injury through activating autophagy via HDAC1/2 inhibition. Food & Function, [PMID:38680105] [10.1039/D4FO01027B]
45. Wu Linjing, Wang Wenhao, Guo Mengqin, Fu Fangqin, Wang Wenhua, Sung Tszching, Zhang Meihong, Zhong Ziqiao, Wu Chuanbin, Pan Xin, Huang Zhengwei. (2024) Inhalable iron redox cycling powered nanoreactor for amplified ferroptosis-apoptosis synergetic therapy of lung cancer. Nano Research, [10.1007/s12274-024-6455-2]
46. Qianrui Huang ,Mengling Wu ,Yamin Pu ,Junyou Zhou ,Yiqian Zhang ,Ru Li ,Yong Xia ,Yiwen Zhang , Yimei Ma. (2024) Inhibition of TNBC Cell Growth by Paroxetine: Induction of Apoptosis and Blockage of Autophagy Flux. Cancers, 16 (5): (885). [PMID:38473249] [10.3390/cancers16050885]
47. Yu Fu, Guiqin Huang, Yawen Cai, Menghui Ren, Run Cheng, Yuhui Chai, Yingdi Wang, Yunqi An, Tianhua Yan, Lingpeng Zhu, Xinxin Liu. (2025) Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:39746501] [10.1016/j.cbi.2024.111368]
48. Cui Tang, Hui Wang, Lina Guo, Yimin Cui, Chan Zou, Jianming Hu, Hanyong Zhang, Guoping Yang, Wenhu Zhou. (2025) Multifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation. ACS Nano, [PMID:39812806] [10.1021/acsnano.4c12131]
49. Jian Wang, Jun Peng, Ling Gao, Jun He, Long Lin, Jia-Meng Li, Ying Xia. (2025) Olfactory mucosa mesenchymal stem cell-derived exosomes protect against neuroinflammation after subarachnoid hemorrhage by activating mitophagy. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, [PMID:39969074] [10.1002/kjm2.12951]
50. Chenchen Zhao, Yan Qin, Haixin Huang, Wei Chen, Yanqing Hu, Xinyu Zhang, Yuying Li, Tian Lan, Wenchao Sun. (2025) PABPC4 Inhibits SADS-CoV Replication by Degrading the Nucleocapsid Protein Through Selective Autophagy. Veterinary Sciences, 12 (3): (257). [PMID:40266995] [10.3390/vetsci12030257]
51. Jindan Xiao, Liuming Xie, Bing Zheng, Wenjie Ma, Yi Chen, Jianhua Xie, Xiaobo Hu, Qiang Yu. (2024) Polygonatum cyrtonema saponin supplementation ameliorated DSS-induced intestinal barrier injury via targeting the PI3K/AKT/mTOR-mediated autophagy/microbiota axis. Food Bioscience, [10.1016/j.fbio.2024.104727]
52. Minghui Cai, Qiuyuan Li, Yang Cao, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu. (2024) Quercetin activates autophagy to protect rats ovarian granulosa cells from H2O2-induced aging and injury. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:38272342] [10.1016/j.ejphar.2024.176339]
53. Guiqin Huang, Yawen Cai, Menghui Ren, Xiaoyu Zhang, Yu Fu, Run Cheng, Yingdi Wang, Mingxing Miao, Lingpeng Zhu, Tianhua Yan. (2024) Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy. Journal of Advanced Research, [PMID:39353532] [10.1016/j.jare.2024.09.027]
54. Xin Shen, Yiqun Xia, Hui Lu, Peisen Zheng, Junqi Wang, Yinghua Chen, Chenxin Xu, Chenyu Qiu, Yafei Zhang, Zhongxiang Xiao, Peng Zou, Ri Cui, Daoyong Ni. (2024) Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells. BIOMEDICINE & PHARMACOTHERAPY, [PMID:38565059] [10.1016/j.biopha.2024.116507]
55. Jiaqi Li, Dezhi Chen, Jialiang Suo, Jiaqi Li, Yimu Zhang, Yu Wang, Zhewen Deng, Qi Zhang, Bo Ma. (2024) Triptolide induced spermatogenesis dysfunction via ferroptosis activation by promoting K63-linked GPX4 polyubiquitination in spermatocytes. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:38960301] [10.1016/j.cbi.2024.111130]
56. Lei Shu, Peili Luo, Qingxin Chen, Jingyang Liu, Ying Huang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2024) Fibroin nanodisruptor with Ferroptosis-Autophagy synergism is potent for lung cancer treatment. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:39142466] [10.1016/j.ijpharm.2024.124582]
57. Shuai Zhan, Ningjing Zhang, Yijie Lou, Xia Ding, Zhe Chen, Yun Huang, Wanjing Ding. (2025) Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:40749867] [10.1016/j.ejphar.2025.178009]
58. Lei Shu, Peili Luo, Chuanyu Ren, Ziwei Lai, Xuejuan Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2025) Inhalable Fibroin Hybrid Liposomes for the Targeted Treatment of Lung Adenocarcinoma via Autophagy-Enhanced Ferroptosis. ACS Nano, [PMID:40878028] [10.1021/acsnano.5c09493]
59. Xiao-Ye Lu, Qian-Yi Lv, Qi-Long Li, Hong Zhang, Chu-Tao Chen, Hao-Mei Tian. (2024) Impact of Acupuncture on Ischemia/Reperfusion Injury: Unraveling the Role of miR-34c-5p and Autophagy Activation. BRAIN RESEARCH BULLETIN, [PMID:39002935] [10.1016/j.brainresbull.2024.111031]
60. Yong Xia, Fuyan Xu, Meiping Xiong, Hao Yang, Wentao Lin, Yao Xie, Huizhi Xi, Qiang Xue, Tinghong Ye, Luoting Yu. (2020) Repurposing of antipsychotic trifluoperazine for treating brain metastasis, lung metastasis and bone metastasis of melanoma by disrupting autophagy flux. PHARMACOLOGICAL RESEARCH, [PMID:33176207] [10.1016/j.phrs.2020.105295]
61. Xi-Hui Yu, Xiao-Qiao Hong, Wen-Hua Chen. (2019) Fluorinated bisbenzimidazoles: a new class of drug-like anion transporters with chloride-mediated, cell apoptosis-inducing activity. ORGANIC & BIOMOLECULAR CHEMISTRY, 17 (6): (1558-1571). [PMID:30694281] [10.1039/C8OB03036G]
62. Ru Li, Yimei Ma, Anqi He, Yamin Pu, Xuanting Wan, Hongbao Sun, Ningyu Wang, Min Luo, Guan Wang, Yong Xia. (2025) Fasting enhances the efficacy of Sorafenib in breast cancer via mitophagy mediated ROS-driven p53 pathway. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:39864757] [10.1016/j.freeradbiomed.2025.01.047]
63. Panpan Xue, Huilan Zhuang, Sijie Shao, Hai Cai, Shumin Tang, Ying Sun, Xuemei Zeng, Shuangqian Yan. (2025) Biodegradable ionic nanoregulators for synchronous modulation of copper and iron ion homeostasis in breast cancer therapy. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2025.162041]
64. Pu Yamin, Xu Fuyan, He Anqi, Li Ru, Wang Xiangxiu, Zhou Liang, Sun Hongbao, Zhang Yiwen, Xia Yong. (2025) Repurposing chlorpromazine for the treatment of triple-negative breast cancer growth and metastasis based on modulation of mitochondria-mediated apoptosis and autophagy/mitophagy. BRITISH JOURNAL OF CANCER, [PMID:40217096] [10.1038/s41416-025-02992-9]
65. Mao Shitao, Yu Na, Wang Wei, Mao Yikai, Du Ying, Zhao Qihe, Gu Xiu, Kang Jian. (2025) Ubiquitin-specific peptidase 10 attenuates bleomycin-induced pulmonary fibrosis via modulating autophagy depending on sirtuin 6-mediated AKT/mTOR. CELL BIOLOGY AND TOXICOLOGY, 41 (1): (1-17). [PMID:40278953] [10.1007/s10565-025-10031-9]
66. Xin-Meng Zhou, Ying Yang, Dao-Jiang Yu, Teng Xie, Xi-Lu Sun, Ying-Xuan Han, Hai-Ying Tian, Qing-Qing Liao, Yu-Jie Zhao, Yih-Cherng Liou, Wei Huang, Yong Xu, Xi Kuang, Xiao-Dong Sun, Yuan-Yuan Zhang. (2025) Naringenin boosts Parkin-mediated mitophagy via estrogen receptor alpha to maintain mitochondrial quality control and heal diabetic foot ulcer. Journal of Pharmaceutical Analysis, [PMID:41487142] [10.1016/j.jpha.2025.101333]
67. Jingchuan He, Tingting Li, Xiaoqin Pan, Zhihua Deng, Jifu Huang, Xiaocheng Mo, Xiaoju Shen, Xiumei Qin, Xingye Yang, Ming Gao, Jie Yang. (2025) CD44 and αV-Integrins Dual-targeting Bimetallic Nanozymes for Lung Adenocarcinoma Therapy via NIR-Enhanced Ferroptosis/Apoptosis. BIOMATERIALS, [PMID:40403445] [10.1016/j.biomaterials.2025.123407]
68. Ting Wen, Yanping Fu, Xiangting Yi, Ying Sun, Wanchen Zhao, Chaonan Shi, Ziyao Chang, Beibei Yang, Shuling Li, Chao Lu, Tingting Peng, Chuanbin Wu, Xin Pan, Guilan Quan. (2025) Autonomous drug delivery and scar microenvironment remodeling using micromotor-driven microneedles for hypertrophic scars therapy. Acta Pharmaceutica Sinica B, [PMID:40698123] [10.1016/j.apsb.2025.05.017]
69. Huang Wenji, Wang Yafang, Ji Ning, Xiao Hehe, Chen Kangyong, Guo Jiahong, Feng Jianhua, Mustafa Nageen, Wang Junya, Feng Hao, Zou Jun. (2025) Zebrafish TRIM2a promotes virus replication via ubiquitination of IRF3 and autophagic cargo receptor p62. JOURNAL OF IMMUNOLOGY, [PMID:40359380] [10.1093/jimmun/vkaf064]
70. Huan Hou, Yaping Yang, Minyan Zhu, Meilin Xie, Yan Zhang, Rong Chen. (2025) Osthole attenuates trastuzumab-induced cardiotoxicity in mice by enhancing autophagy via regulating the p38MAPK/mTOR signaling pathway. Journal of Traditional and Complementary Medicine, [10.1016/j.jtcme.2025.06.001]
71. Chenchen Zhao, Yan Qin, Haixin Huang, Yuying Li, Xinyu Zhang, Lin Zhou, Lulu Xie, Yimin Zhou, Yanqing Hu, Wei Chen, Tian Lan, Wen-Chao Sun. (2025) BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway. Microorganisms, 13 (8): (1865). [PMID:40871369] [10.3390/microorganisms13081865]
72. Cai Minghui, Guo Qi, Li Jiaxin, Dai Xiaoqi, Su Huiyu, Zhang Wenwen, Qiang Na, Li Geng, Jin Zihan, Zhu Hui. (2025) Resveratrol Attenuates H2O2-induced Aging and Apoptosis in Mouse Hippocampal Neuron HT22 Cells by Activating Autophagy via the SIRT1/FoxO1 Signaling Pathway. MOLECULAR NEUROBIOLOGY, 63 (1): (1-14). [PMID:41203934] [10.1007/s12035-025-05489-x]
73. Chunyang Zhu, Shuming Chen, Yangyang Lu, Jialin Song, Shasha Wang, Jing Guo, Xiaoxi Han, YuanYuan Fang, Siyi Zhang, Wensheng Qiu, Weiwei Qi. (2025) Timosaponin AIII inhibits gastric cancer by causing oxidative stress and blocking autophagic flux. Translational Oncology, [PMID:40738018] [10.1016/j.tranon.2025.102481]
74. Cui Zichen, Gu Guanghui, Chen Fei, Li Jianyi, Du Xiaofan, Chen Shuqing, Zhang Han, Li Chenxu, Shao Jiale, Xi Jiayi, Du Yukun, Zhao Qinghua, Xi Yongming. (2025) Targeting Irgm1 to combat osteoporosis: suppressing ROS and restoring bone remodeling. Cell Death & Disease, 16 (1): (1-16). [PMID:40866352] [10.1038/s41419-025-07965-7]
75. Fu Wenying, Lu Hui, Yan Ying, Shu Chongchong, Xu Chenxin, Chen Yinghua, Xia Yiqun, Chen Jundixia, Chen Yunzhi, Zou Peng, Cui Ri, Ni Daoyong. (2025) Combination of B-AP15 and HSP90 inhibitor tanespimycin induces ROS-mediated cytotoxicity in human lung cancer cells. BMC Pharmacology & Toxicology, 26 (1): (1-13). [PMID:41153057] [10.1186/s40360-025-01009-8]
76. Pingcui Xu, Yuzhen Xia, Leqian Wang, Lisha Zhao, Chao Feng, Mingli Ye, Kai Huang, Nani Wang. (2025) Anemarrhena asphodeloides-derived small extracellular vesicle ameliorate diabetes-induced muscle atrophy via activating Pink1-mediated mitophagy. PHYTOMEDICINE, [PMID:41308393] [10.1016/j.phymed.2025.157573]
77. Wenying Fu, Ying Yan, Chongchong Shu, Chenxin Xu, Yinghua Chen, Yiqun Xia, Jundixia Chen, Yunzhi Chen, Ri Cui, Peng Zou, Daoyong Ni. (2026) 6-Methoxydihydrosanguinarine synergizes with cisplatin to enhance lung cancer cell death via ROS-mediated autophagy, ER stress, and JNK activation. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:41534554] [10.1016/j.ejphar.2026.178544]
78. Jiaqi Li, Zhengxin Lu, Nan Zhang, Xiaowei Zhou, Yuanbiao Ma, Jia-qi Li, Yimu Zhang, Zhewen Deng, Na Lin, Peng Yue, Yilin Yang, Qi Zhang, Bo Ma. (2026) Andrographolide induces testicular damage by triggering ferroptosis in Sertoli cells via disruption of β-TrCP-mediated ATF4 ubiquitination and degradation. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:41865780] [10.1016/j.cbi.2026.112052]
79. Kong Wenbin, Su Baoqiang, Gu Han, Huang Weiqiang, Wang Jing, Zhu Yaqi, Xu Rongrong, Tong Dali, Xu Weiping. (2026) GSH-Responsive Co-Delivery of Chrysin and 3-Methyladenine Disrupts Tumor Adaptive Stress for Synergistic Antitumor Therapy. ACS Omega, 11 (28): (42728-42741). [PMID:42495282] [10.1021/acsomega.6c04046]