| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A412006-100μg |
100μg |
现货  |
| |
| A412006-1mg |
1mg |
现货 |
| |
| A412006-5mg |
5mg |
现货 |
| |
| A412006-10mg |
10mg |
期货 |
|
| 产品名称 | Avelumab (anti-PD-L1), 程序性细胞死亡 1 配体的 OTHER 1 其他 |
|---|---|
| 别名 | 阿维单抗（抗 PD-L1） |
| 英文别名 | Recombinant Avelumab Antibody | Avelumab | Anti-Human PD-L1, Human Antibody | Anti-PD-L1 | MSB0010718C | Bavencio | B7 H antibody | B7 H1 antibody | B7 homolog 1 antibody | B7-H1 antibody | B7H antibody | B7H1 antibody | CD 274 antibody | CD-274 antibody |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | B7-H1 / PD-L1 / CD274 |
| 应用 | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| 种属反应性 | 人(Human),兔(Rabbit),大鼠(Rat),小鼠(Mouse),狗(Dog),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 其它 |
| 作用机制 | 程序性细胞死亡 1 配体的 OTHER 1 其他 |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆类型 | 重组抗体 |
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | lambda |
| SDS-PAGE | 28.7 kDa (Light Chain) & 50.1 kDa (Heavy Chain), under reducing conditions; 182.4 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1537032-82-8 |
| 分子类型 | 抗体 |
Avelumab (anti-PD-L1) (A412006) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling PD-L1 with Avelumab (anti-PD-L1) (A412006) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Avelumab (anti-PD-L1) (A412006) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling PD-L1 (red) with Avelumab (anti-PD-L1) (A412006) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Avelumab (anti-PD-L1) (A412006) - SEC
The purity of Avelumab (anti-PD-L1) (A412006) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
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| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1012698 |
分析证书 | 24-10-23 | A412006 |
| ZJ24F1012697 |
分析证书 | 24-10-23 | A412006 |
| ZJ24F1012696 |
分析证书 | 24-10-23 | A412006 |
| ZJ24F0404943 |
分析证书 | 24-04-26 | A412006 |
| ZJ23F1101612 |
分析证书 | 23-11-08 | A412006 |
| ZJ23F1101613 |
分析证书 | 23-11-08 | A412006 |
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| 1. Pardoll DM. (2012) The blockade of immune checkpoints in cancer immunotherapy.. Nat Rev Cancer, 12 (4): (252-64). [PMID:22437870] [10.1021/op500134e] |
| 2. Topalian SL, Drake CG, Pardoll DM. (2015) Immune checkpoint blockade: a common denominator approach to cancer therapy.. Cancer Cell, 27 (4): (450-61). [PMID:25858804] [10.1021/op500134e] |
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